Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Lucia, Coppo"'
Autor:
Giulia Blandino, Mara Fiorani, Barbara Canonico, Rita De Matteis, Andrea Guidarelli, Mariele Montanari, Gloria Buffi, Lucia Coppo, Elias S.J. Arnér, Orazio Cantoni
Publikováno v:
Redox Biology, Vol 67, Iss , Pp 102915- (2023)
Long-term treatment of schizophrenia with clozapine (CLZ), an atypical antipsychotic drug, is associated with an increased incidence of metabolic disorders mediated by poorly understood mechanisms. We herein report that CLZ, while slowing down the mo
Externí odkaz:
https://doaj.org/article/d1328900c1f641a38923911fd7ee06ff
Autor:
Valeria Scalcon, Alessandra Folda, Maria Giovanna Lupo, Federica Tonolo, Naixuan Pei, Ilaria Battisti, Nicola Ferri, Giorgio Arrigoni, Alberto Bindoli, Arne Holmgren, Lucia Coppo, Maria Pia Rigobello
Publikováno v:
Redox Biology, Vol 51, Iss , Pp 102277- (2022)
Glutaredoxin 2 (Grx2) is a glutathione-dependent oxidoreductase that facilitates glutathionylation/de-glutathionylation of target proteins. The main variants of Grx2 are the mitochondrial Grx2a and the cytosolic Grx2c. The aim of this study was to in
Externí odkaz:
https://doaj.org/article/d28614f02f9f4caf890059aedd389671
Publikováno v:
Redox Biology, Vol 43, Iss , Pp 101975- (2021)
Glutaredoxin, Grx, is a small protein containing an active site cysteine pair and was discovered in 1976 by Arne Holmgren. The Grx system, comprised of Grx, glutathione, glutathione reductase, and NADPH, was first described as an electron donor for R
Externí odkaz:
https://doaj.org/article/a38d669cac324ed98c7a6360f6307952
Publikováno v:
Toxics, Vol 10, Iss 8, p 433 (2022)
Mercury (Hg) is known for its neurotoxicity and is reported to activate microglia cells at low exposure levels. Since mercury decreases the activity of the glutathione and thioredoxin systems, we hypothesize that Hg would, in turn, disrupt microglia
Externí odkaz:
https://doaj.org/article/9a1f7f74d00a4a16aca11d8d8f6d2ac2
Autor:
Lena Haffo, Jun Lu, Vladimir J. N. Bykov, Sebastin S. Martin, Xiaoyuan Ren, Lucia Coppo, Klas G. Wiman, Arne Holmgren
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Abstract The tumor suppressor p53 is commonly inactivated in human tumors, allowing evasion of p53-dependent apoptosis and tumor progression. The small molecule APR-246 (PRIMA-1Met) can reactive mutant p53 in tumor cells and trigger cell death by apo
Externí odkaz:
https://doaj.org/article/5919892998d44e63a8772d90b40e9d3a
Autor:
Vasco Branco, Lucia Coppo, Susana Solá, Jun Lu, Cecília M.P. Rodrigues, Arne Holmgren, Cristina Carvalho
Publikováno v:
Redox Biology, Vol 13, Iss C, Pp 278-287 (2017)
Mercury (Hg) compounds target both cysteine (Cys) and selenocysteine (Sec) residues in peptides and proteins. Thus, the components of the two major cellular antioxidant systems – glutathione (GSH) and thioredoxin (Trx) systems – are likely target
Externí odkaz:
https://doaj.org/article/e71866dab99747579be1e4fdb45a6ee6
Autor:
Aida Rodriguez-Garcia, David Hevia, Juan C. Mayo, Pedro Gonzalez-Menendez, Lucia Coppo, Jun Lu, Arne Holmgren, Rosa M. Sainz
Publikováno v:
Redox Biology, Vol 12, Iss , Pp 634-647 (2017)
Accumulating evidence suggests that natural bioactive compounds, alone or in combination with traditional chemotherapeutic agents, could be used as potential therapies to fight cancer. In this study, we employed four natural bioactive compounds (curc
Externí odkaz:
https://doaj.org/article/b0e40129d39446a9bcbbc8944e54f153
Autor:
Justin R. Prigge, Lucia Coppo, Sebastin S. Martin, Fernando Ogata, Colin G. Miller, Michael D. Bruschwein, David J. Orlicky, Colin T. Shearn, Jean A. Kundert, Julia Lytchier, Alix E. Herr, Åse Mattsson, Matthew P. Taylor, Tomas N. Gustafsson, Elias S.J. Arnér, Arne Holmgren, Edward E. Schmidt
Publikováno v:
Cell Reports, Vol 19, Iss 13, Pp 2771-2781 (2017)
Energetic nutrients are oxidized to sustain high intracellular NADPH/NADP+ ratios. NADPH-dependent reduction of thioredoxin-1 (Trx1) disulfide and glutathione disulfide by thioredoxin reductase-1 (TrxR1) and glutathione reductase (Gsr), respectively,
Externí odkaz:
https://doaj.org/article/608638e94517493f8c9dd7af8d0965f9
Autor:
Colin G. Miller, Jean A. Kundert, Justin R. Prigge, Julie A. Amato, Allison E. Perez, Lucia Coppo, Gabrielle N. Rizzo, Michael P. Kavanaugh, David J. Orlicky, Colin T. Shearn, Edward E. Schmidt
Publikováno v:
Antioxidants, Vol 10, Iss 3, p 359 (2021)
Cellular oxidants are primarily managed by the thioredoxin reductase-1 (TrxR1)- and glutathione reductase (Gsr)-driven antioxidant systems. In mice having hepatocyte-specific co-disruption of TrxR1 and Gsr (TrxR1/Gsr-null livers), methionine cataboli
Externí odkaz:
https://doaj.org/article/98510a8d188d4921848458dea2409ac7
Autor:
Lucia Coppo, Simona Scheggi, Graziella DeMontis, Raffaella Priora, Simona Frosali, Antonio Margaritis, Domenico Summa, Danila Di Giuseppe, Monica Ulivelli, Paolo Di Simplicio
Publikováno v:
Antioxidantsredox signaling.
Increased plasma concentrations of total homocysteine (tHcy) (mild-moderate hyperhomocysteinemia: 15-50 µM tHcy) are considered an independent risk factor for onset/progression of various diseases, but it is not known how the increase in tHcy causes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f821dd9c187555bcc92e6a603e63c35
https://pubmed.ncbi.nlm.nih.gov/36352822
https://pubmed.ncbi.nlm.nih.gov/36352822