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Akademický článek
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Autor:
Doty, David, Kornerup, Niels, Luchsinger, Austin, Orshansky, Leo, Soloveichik, David, Woods, Damien
The key factor currently limiting the advancement of computational power of electronic computation is no longer the manufacturing density and speed of components, but rather their high energy consumption. While it has been widely argued that reversib
Externí odkaz:
http://arxiv.org/abs/2309.06957
Discrete chemical reaction networks formalize the interactions of molecular species in a well-mixed solution as stochastic events. Given their basic mathematical and physical role, the computational power of chemical reaction networks has been widely
Externí odkaz:
http://arxiv.org/abs/2307.01939
Autor:
Medha N. Munshi, Elizabeth M. Venditti, Ashley H. Tjaden, William C. Knowler, Edward J. Boyko, Roeland J. W. Middelbeek, José A. Luchsinger, Christine G. Lee, Helen P. Hazuda, Marcel E. Salive, Sharon L. Edelstein, Thomas W. Storer
Publikováno v:
Frontiers in Public Health, Vol 12 (2024)
ObjectivesType 2 diabetes (T2D) and prediabetes are associated with poor walking endurance, a marker of physical function. We aimed to examine the long-term effects of metformin or intensive lifestyle intervention in adults at high risk of T2D on the
Externí odkaz:
https://doaj.org/article/eab980a6135447d297de9912612a8747
Plasma brain-derived tau is an amyloid-associated neurodegeneration biomarker in Alzheimer’s disease
Autor:
Fernando Gonzalez-Ortiz, Bjørn-Eivind Kirsebom, José Contador, Jordan E. Tanley, Per Selnes, Berglind Gísladóttir, Lene Pålhaugen, Mathilde Suhr Hemminghyth, Jonas Jarholm, Ragnhild Skogseth, Geir Bråthen, Gøril Grøndtvedt, Atle Bjørnerud, Sandra Tecelao, Knut Waterloo, Dag Aarsland, Aida Fernández-Lebrero, Greta García-Escobar, Irene Navalpotro-Gómez, Michael Turton, Agnes Hesthamar, Przemyslaw R. Kac, Johanna Nilsson, Jose Luchsinger, Kathleen M. Hayden, Peter Harrison, Albert Puig-Pijoan, Henrik Zetterberg, Timothy M. Hughes, Marc Suárez-Calvet, Thomas K. Karikari, Tormod Fladby, Kaj Blennow
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Staging amyloid-beta (Aβ) pathophysiology according to the intensity of neurodegeneration could identify individuals at risk for cognitive decline in Alzheimer’s disease (AD). In blood, phosphorylated tau (p-tau) associates with Aβ patho
Externí odkaz:
https://doaj.org/article/b027901016fa4e8ba7386d92b8d8e45e
Autor:
Beat M. Greiter, Semjon Sidorov, Ester Osuna, Michelle Seiler, Christa Relly, Annette Hackenberg, Isabelle Luchsinger, Elvira Cannizzaro, Roland Martin, Martina Marchesi, Stefanie von Felten, Adrian Egli, Christoph Berger, Patrick M. Meyer Sauteur
Publikováno v:
The Lancet Regional Health. Europe, Vol 48, Iss , Pp 101143- (2025)
Summary: Background: Lyme disease (LD) is caused by Borrelia burgdorferi and is the most common tickborne disease in the northern hemisphere. Although classical characteristics of LD are well-known, the diagnosis and treatment are often delayed. Labo
Externí odkaz:
https://doaj.org/article/e2f324252f0f4d2c972bf849fa4d9e1d
Autor:
Angel Bulnes-Ramos, Kerstin Schott, Jesse Rabinowitz, Charlotte Luchsinger, Cinzia Bertelli, Eri Miyagi, Corey H. Yu, Mirjana Persaud, Caitlin Shepard, Renate König, Baek Kim, Dmitri N. Ivanov, Klaus Strebel, Felipe Diaz-Griffero
Publikováno v:
mBio, Vol 15, Iss 9 (2024)
ABSTRACT In humans, sterile alpha motif (SAM) domain- and histidine–aspartic acid (HD) domain-containing protein 1 (SAMHD1) is a dNTPase enzyme that prevents HIV-1 infection in non-cycling cells, such as differentiated THP-1 cells and human primary
Externí odkaz:
https://doaj.org/article/c9f56ba73d444171b8aaf82bbd3b5756
Autor:
Nada El Husseini, Christopher L. Schaich, Suzanne Craft, Stephen R. Rapp, Kathleen M. Hayden, Richey Sharrett, Mary Frances Cotch, Tien Y. Wong, Jose A. Luchsinger, Mark A. Espeland, Laura D. Baker, Alain G. Bertoni, Timothy M. Hughes
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Retinal vessel calibers share anatomic and physiologic characteristics with the cerebral vasculature and can be visualized noninvasively. In light of the known microvascular contributions to brain health and cognitive function, we aimed to d
Externí odkaz:
https://doaj.org/article/6bc37cff2dbf4539929a234764bc934d
Autor:
Mariagnese Barbera, Jenni Lehtisalo, Dinithi Perera, Malin Aspö, Mary Cross, Celeste A. De Jager Loots, Emanuela Falaschetti, Naomi Friel, José A. Luchsinger, Hanna Malmberg Gavelin, Markku Peltonen, Geraint Price, Anna Stigsdotter Neely, Charlotta Thunborg, Jaakko Tuomilehto, Francesca Mangialasche, Lefkos Middleton, Tiia Ngandu, Alina Solomon, Miia Kivipelto, on behalf of the MET-FINGER study team
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-15 (2024)
Abstract Background Combining multimodal lifestyle interventions and disease-modifying drugs (novel or repurposed) could provide novel precision approaches to prevent cognitive impairment. Metformin is a promising candidate in view of the well-establ
Externí odkaz:
https://doaj.org/article/cf2e67842eb94bb2b2088bff9d888756
Publikováno v:
Proceedings of the National Academy of Sciences, 119(24):e2111552119, 2022
Embedding computation in biochemical environments incompatible with traditional electronics is expected to have wide-ranging impact in synthetic biology, medicine, nanofabrication and other fields. Natural biochemical systems are typically modeled by
Externí odkaz:
http://arxiv.org/abs/2109.11422