Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Luchen Shan"'
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/c2d0553b912247bcae4d3d3ca2fc8b07
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Objective: Potentially inappropriate medications (PIM) contribute to poor outcomes in older patients, making it a widespread health problem. The study explored the occurrence and risk factors of PIM in older diabetic kidney disease (DKD) patients dur
Externí odkaz:
https://doaj.org/article/f14c5f03232e417c85af9d37879271ca
Autor:
Yangwen Luo, Luchen Shan, Lipeng Xu, Srinivas Patnala, Isadore Kanfer, Jiahao Li, Pei Yu, Xu Jun
Publikováno v:
PLoS ONE, Vol 17, Iss 8, p e0273583 (2022)
Sceletium tortuosum (SCT) has been utilized medicinally by indigenous Koi-San people purportedly for mood elevation. SCT extracts are reported to be neuroprotective and have efficacy in improving cognition. However, it is still unclear which of the p
Externí odkaz:
https://doaj.org/article/f959725e60084b8da910901499b25612
Autor:
Xinhua Zhou, Anqi Wang, Liang Wang, Jianhua Yin, Li Wang, Lijun Di, Maggie Pui-Man Hoi, Luchen Shan, Xu Wu, Yuqiang Wang
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Background: We previously demonstrated that a Danshensu-Tetramethylpyrazine conjugate DT-010 enhanced anticancer effect of doxorubicin (Dox) in Dox-sensitive human breast cancer cells, and protected against Dox-induced cardiotoxicity. This work was d
Externí odkaz:
https://doaj.org/article/69dbfe0fab4d4e30b4d62759c6c0f0ee
Autor:
Haiyun Chen, Jie Cao, Zeyu Zhu, Gaoxiao Zhang, Luchen Shan, Pei Yu, Yuqiang Wang, Yewei Sun, Zaijun Zhang
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
Glutamate-induced excitotoxicity is one of the main causes of neuronal cell death in stroke. Compound 22a has been previously reported as a promising neuroprotective compound derived from tetramethylpyrazine, which is a widely used active ingredient
Externí odkaz:
https://doaj.org/article/80b5e2cd6cbd4f5881f04001bd2fb51a
Autor:
Shengquan Hu, Huihui Hu, Shinghung Mak, Guozhen Cui, Mingyuen Lee, Luchen Shan, Yuqiang Wang, Huangquan Lin, Zaijun Zhang, Yifan Han
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
The over-activation of NMDA receptor via the excessive glutamate is believed to one of the most causal factors associated with Alzheimer’s disease (AD), a progressive neurodegenerative brain disorder. Molecules that could protect against glutamate-
Externí odkaz:
https://doaj.org/article/8ff207ea050c4395bb248881a6279c28
Autor:
Liang Wang, Judy Yuet-Wa Chan, Xinhua Zhou, Guozhen Cui, Zhixiang Yan, Li Wang, Ru Yan, Lijun Di, Yuqiang Wang, Maggie Pui-Man Hoi, Luchen Shan, Simon M Y Lee
Publikováno v:
Frontiers in Pharmacology, Vol 7 (2016)
We have previously demonstrated that DT-010, a novel conjugate of danshensu (DSS) and tetramethylpyrazine (TMP), displays antitumor effects in breast cancer cells both in vitro and in vivo. In the present study, we investigated whether DT-010 enhance
Externí odkaz:
https://doaj.org/article/8f3f708569e44267831ffecc84a4e219
Publikováno v:
Current Pharmaceutical Analysis. 18:892-900
Background: Long-term nitroglycerin (NTG) therapy causes tolerance, which limits its clinical application. Previous studies have reported a novel Danshensu/tetramethylpyrazine derivative ADTM, which displays strong cardioprotective effects. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c330d642e11371535b869df2e8e77d23
https://doi.org/10.2174/1573412918666220831101931
https://doi.org/10.2174/1573412918666220831101931
Publikováno v:
Biochemical and Biophysical Research Communications. 618:141-147
Nitroglycerin (NTG) is recommended as the first-line drug in angina pectoris though its prolonged use impacts nitroglycerin tolerance. In this study, we investigated the preventive effect of Tetramethylpyrazine (TMP), a famous Chinese medicine used f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29539b2961eb40fa4be3457e20e1a1ef
https://doi.org/10.1016/j.bbrc.2022.06.013
https://doi.org/10.1016/j.bbrc.2022.06.013
Autor:
Tangjia, Li, Chu, Zhang, Yuke, Wei, Haijing, Zhong, Luchen, Shan, Pei, Yu, Yuqiang, Wang, Lipeng, Xu
Publikováno v:
Current Pharmaceutical Design. 28:2508-2517
Background: Acute lung injury (ALI) is a serious respiratory disease with a high mortality rate, and there is an urgent need for a more effective treatment strategy. Andrographolide derivative AL-1 has been identified to possess anti-inflammatory act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efcd34e182297ac5d28e9eeb8601667b
https://doi.org/10.2174/1381612828666220729094806
https://doi.org/10.2174/1381612828666220729094806