Výsledky vyhledávání - "Lucette, Garreau"

Akademický článek

Translocator Protein (18 kDa) Mapping with [I]-CLINDE in the Quinolinic Acid Rat Model of Excitotoxicity: A Longitudinal Comparison with Microglial Activation, Astrogliosis, and Neuronal Death

Autor: Nicolas Arlicot, Claire Tronel, Sylvie Bodard, Lucette Garreau, Brice de la Crompe, Inge Vandevelde, Denis Guilloteau, Daniel Antier, Sylvie Chalon

Publikováno v: Molecular Imaging, Vol 13 (2014)

Excitotoxicity leads to an inflammatory reaction involving an overexpression of: translocator protein 18 kDa (TSPO) in cerebral microglia and astrocytes. Therefore, we performed ex vivo explorations with [ 125 ]-CLINDE, a TSPO-specific radioligand, t

Externí odkaz: https://doaj.org/article/6f497c42babc46b8bd5b0edaca857d2e

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In vivo PET quantification of the dopamine transporter in rat brain with [18F]LBT-999

Autor: Jean-Bernard Deloye, Sylvie Chalon, Clovis Tauber, Lucette Garreau, Denis Guilloteau, Sophie Serriere, Johnny Vercouillie, Laurent Galineau

Publikováno v: Nuclear Medicine and Biology; Vol 41
Nuclear Medicine and Biology

article i nfo Introduction: We examined whether ( 18 F)LBT-999 ((E)-N-(4-fluorobut-2-enyl)2β-carbomethoxy-3β-(4'- tolyl)nortropane) is an efficient positron emission tomography (PET) tracer for the quantification of the dopamine transporter (DAT) i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::826a9d00180d3a96273ca43d30284bf2
https://doi.org/10.1016/j.nucmedbio.2013.09.007

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Behavior and serotonergic disorders in rats exposed prenatally to valproate: A model for autism

Autor: Catherine Belzung, David Ternant, Emilie Jaumain, Patrick Vourc'h, Lucette Garreau, Sylvie Chalon, Diane Dufour-Rainfray, Denis Guilloteau, Anne-Marie Le Guisquet, Christian R. Andres, Zuhal Gulhan, Sylvie Bodard

Publikováno v: Neuroscience Letters. 470:55-59

In order to explore whether some aspects of the autistic phenotype could be related to impairment of the serotonergic system, we chose an animal model which mimics a potential cause of autism, i.e. rats exposed to valproate (VPA) on the 9th embryonic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cdd92e5f8061c2d9e8b22d5fc53609f
https://doi.org/10.1016/j.neulet.2009.12.054

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Docking study, synthesis, and in vitro evaluation of fluoro-MADAM derivatives as SERT ligands for PET imaging

Autor: Lucette Garreau, Johnny Vercouillie, Sylvie Chalon, Denis Guilloteau, Tiziana Raguza, Aina Westrheim Ravna, Patrick Emond, Sylvie Mavel

Publikováno v: Bioorganic & Medicinal Chemistry. 16:9050-9055

In order to predict affinity of new diphenylsulfides for the serotonin transporter (SERT), a molecular modeling model was used to compare potential binding affinity of new compounds with known potent ligands. The aim of this study is to identify a su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b085c573623a0b4a4d54a69a093abbf5
https://doi.org/10.1016/j.bmc.2008.08.002

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Improved synthesis and metabolic stability analysis of the dopamine transporter ligand [18F]FECT

Autor: Satish K. Chitneni, Lucette Garreau, Guy Bormans, Alfons Verbruggen, Denis Guilloteau, Nele Evens, Sylvie Chalon, B. Cleynhens, Koen Van Laere, Peter Vermaelen, Marva Bex, Roger Busson

Publikováno v: Nuclear Medicine and Biology. 35:75-82

Introduction [2′-[ 18 F]Fluoroethyl (lR-2-exo-3-exe)-8-methyl-3-(4-chlorophenyl)-8-azabicyclo[3.2.1]-octane-2-carboxylate] ([ 18 F]FECT) is a positron emission tomography (PET) tracer for imaging the dopamine transporter (DAT) in vivo. We report an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9c547ca2005e9c951c1589c19894d6b
https://doi.org/10.1016/j.nucmedbio.2007.09.001

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Radiosynthesis of [18F]LBT-999, a selective radioligand for the visualization of the dopamine transporter with PET

Autor: Héric Valette, Lucette Garreau, Christer Halldin, Jean-Bernard Deloye, Jean-Claude Madelmont, Wadad Saba, Patrick Emond, Julie Helfenbein, Marie-Anne Schöllhorn-Peyronneau, Frédéric Dollé, Françoise Hinnen, Sylvie Mavel, Zoia Mincheva, Sylvie Chalon, Denis Guilloteau, Michel Bottlaender, Joël Legaillard

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 49:687-698

LBT-999 (8-((E)-4-fluoro-but-2-enyl)-3-beta-p-tolyl-8-aza-bicyclo[3.2.1]octane-2-beta-carboxylicacid methyl ester) is a recently developed cocaine derivative belonging to a new generation of highly selective dopamine transporter (DAT) ligands (KD: 9

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ba79f08fba11826c09b16ca34b42853
https://doi.org/10.1002/jlcr.1092

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Pharmacological Characterization of (E)-N-(4-Fluorobut-2-enyl)-2β-carbomethoxy-3β-(4′-tolyl)nortropane (LBT-999) as a Highly Promising Fluorinated Ligand for the Dopamine Transporter

Autor: Sylvie Bodard, Lucette Garreau, Christer Halldin, Denis Guilloteau, Håkan Hall, Michel Bottlaender, Julie Helfenbein, Wadad Saba, Frédéric Dollé, Jean-Claude Besnard, Sylvie Chalon, Patrick Emond, Jean-Bernard Deloye, Jean-Claude Madelmont, Zoia Mincheva

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 317:147-152

In the aim to develop an efficient fluorinated probe for positron emission tomography (PET) exploration of the dopamine transporter (DAT), we studied several in vitro and in vivo characteristics of the phenyltropane derivative (E)-N-(4-fluorobut-2-en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c3f96431d1d5061dd87b9787b2583c1
https://doi.org/10.1124/jpet.105.096792

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Amyloid load and translocator protein 18 kDa in APPswePS1-dE9 mice: a longitudinal study

Autor: Guylène Page, Michael Kassiou, Sylvie Chalon, Céline Mothes, Johnny Vercouillie, Clovis Tauber, Aurélie Doméné, Lucette Garreau, Sophie Serrière, Denis Guilloteau, Christelle Pruckner

Publikováno v: Neurobiology of aging. 36(4)

We studied concomitantly the level of neuroinflammation and β-amyloid (Aβ) load in the APPswePS1dE9 transgenic mouse model of Alzheimer's disease using positron emission tomography. The translocator protein 18 kDa (TSPO) tracer [(18)F]DPA-714 was u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af49e02498cc6709f615490a9e15d91c
https://pubmed.ncbi.nlm.nih.gov/25680265

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