Antigen Geometry Tunes Mast Cell Signaling Through Distinct FcεRI Aggregation and Structural Changes.

Autor: Rinaldi DA; Department of Pathology, University of New Mexico, Albuquerque, NM 87131., Kanagy WK; Department of Pathology, University of New Mexico, Albuquerque, NM 87131.; Present address: Department of Immunology, University of Minnesota, Minneapolis, MN 55455., Kaye HC; Department of Pathology, University of New Mexico, Albuquerque, NM 87131., Grattan RM; Department of Pathology, University of New Mexico, Albuquerque, NM 87131., Lucero SR; Department of Pathology, University of New Mexico, Albuquerque, NM 87131., Pérez MP; Department of Pathology, University of New Mexico, Albuquerque, NM 87131., Wester MJ; Department Physics and Astronomy, University of New Mexico, Albuquerque, NM 87131., Lidke KA; Department Physics and Astronomy, University of New Mexico, Albuquerque, NM 87131.; Comprehensive Cancer Center, University of New Mexico, Albuquerque, NM 87131., Wilson BS; Department of Pathology, University of New Mexico, Albuquerque, NM 87131.; Comprehensive Cancer Center, University of New Mexico, Albuquerque, NM 87131., Lidke DS; Department of Pathology, University of New Mexico, Albuquerque, NM 87131.; Comprehensive Cancer Center, University of New Mexico, Albuquerque, NM 87131.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Aug 07. Date of Electronic Publication: 2023 Aug 07.

Allergen Valency, Dose, and FcεRI Occupancy Set Thresholds for Secretory Responses to Pen a 1 and Motivate Design of Hypoallergens.

Autor: Mahajan A; Department of Pathology, University of New Mexico, Albuquerque, NM 87131., Youssef LA; Department of Pharmaceutics and Pharmaceutical Technology, School of Pharmacy, Damascus University, Damascus, Syria.; National Commission for Biotechnology, Damascus, Syria., Cleyrat C; Department of Pathology, University of New Mexico, Albuquerque, NM 87131., Grattan R; Department of Pathology, University of New Mexico, Albuquerque, NM 87131., Lucero SR; Department of Pathology, University of New Mexico, Albuquerque, NM 87131., Mattison CP; Southern Regional Research Center, Agricultural Research Service, U.S. Department of Agriculture, New Orleans, LA 70124., Erasmus MF; Department of Pathology, University of New Mexico, Albuquerque, NM 87131., Jacobson B; Department of Computer Sciences, University of New Mexico, Albuquerque, NM 87131., Tapia L; Department of Computer Sciences, University of New Mexico, Albuquerque, NM 87131., Hlavacek WS; Theoretical Biology and Biophysics Group, Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM 87545.; Theoretical Biology and Biophysics Group, Center for Nonlinear Studies, Los Alamos National Laboratory, Los Alamos, NM 87545; and., Schuyler M; Department of Medicine, University of New Mexico, Albuquerque, NM 87131., Wilson BS; Department of Pathology, University of New Mexico, Albuquerque, NM 87131; bwilson@salud.unm.edu.

Publikováno v: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2017 Feb 01; Vol. 198 (3), pp. 1034-1046. Date of Electronic Publication: 2016 Dec 30.