Výsledky vyhledávání - "Lucero Bautista"

In vitro and In vivo Effects of 17β-N-(4-phenylcarbamoyl) androst-4-en-3- one Derivatives as 5a-reductase Inhibitors on Androgen-dependent Glands

Autor: Juan Soriano, Marisa Cabeza, Yvonne Heuze, Eugene Bratoeff, Lucero Bautista

Publikováno v: Current Enzyme Inhibition. 17:16-25

Introduction: 5α-reductase inhibitors have been proven useful for the treatment of prostate diseases, which can be due to the unregulated activity of 5α-reductase enzyme. This study was focused on determining the activity of four different derivati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::056d6628aaec27946ca8a3f56e6ed41d
https://doi.org/10.2174/1573408016999200928153524

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Effect of Pregnenolone Derivatives on the Selective Inhibition of 5α-Reductase 2 Activity

Autor: Lucero Bautista, Eugene Bratoeff, Juan Soriano, Marisa Cabeza, Yvonne Heuzr

Publikováno v: Current Enzyme Inhibition. 15:179-189

Background:Benign prostatic hyperplasia and prostate cancer are androgen-dependent diseases, and dihydrotestosterone (DHT), a 5α-reduced metabolite of testosterone (T), has been implicated as a causative factor in the progression of these diseases.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5604fb2b26cf936fc0e5a8b4e7966d8
https://doi.org/10.2174/1573408015666191105144355

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Molecular Interactions of Different Steroids Contributing to Sebum Production. Review

Autor: Yvonne Heuze, Marisol Bravo, Marisa Cabeza, Lucero Bautista

Publikováno v: Current Drug Targets. 19:1855-1865

Considerable progress has been made in learning about the physiology and biochemistry of the sebaceous glands and several of the diseases that affect this component of the skin. Of these diseases, acne has particular importance. It is associated with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbf37984add4de65c7f1e4bd5db9eee2
https://doi.org/10.2174/1389450119666180808113951

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Synthesis of new derivatives of 21-imidazolyl-16-dehydropregnenolone as inhibitors of 5α-reductase 2 and with cytotoxic activity in cancer cells

Autor: Marisol Bravo, Eugene Bratoeff, Isabel Moreno, Teresa Ramírez-Apan, Yvonne Heuze, Lucero Bautista, Aylin Viviana Silva-Ortiz, Juan Soriano, Marisa Cabeza

Publikováno v: Bioorganic & Medicinal Chemistry. 25:1600-1607

The aim of this study was to synthesize several 16-dehydropregnenolone derivatives containing an imidazole ring at C-21 and a different ester moiety at C-3 as inhibitors of 5α-reductase 1 and 2 isoenzymes. Their binding capacity to the androgen rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0eadfe43807b2d062c460d5fa4d36e9
https://doi.org/10.1016/j.bmc.2017.01.018

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SAT-329 Novel Dehydroepiandrosterone Derivatives Inhibiting Metastatic Prostate Cancer Cell Proliferation

Autor: Yvonne Heuze, Marisa Cabeza, Lucero Bautista

Publikováno v: Journal of the Endocrine Society

Abstract: Metastatic prostate tumor cells mainly express type 1 5α-reductase and have been linked to antiandrogenic resistant prostate cancers. However, the isozyme of type 2 5α-reductase is mostly expressed in normal prostate epithelial cells and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dea1384950950e7e1ea6e6138730ae0
http://europepmc.org/articles/PMC6552093

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