Výsledky vyhledávání - "Luce Skrabanek"

Akademický článek

Structural Mapping and Functional Characterization of Zebrafish Class B G-Protein Coupled Receptor (GPCR) with Dual Ligand Selectivity towards GLP-1 and Glucagon.

Autor: Deena A Oren, Yang Wei, Luce Skrabanek, Billy K C Chow, Thomas Mommsen, Svetlana Mojsov

Publikováno v: PLoS ONE, Vol 11, Iss 12, p e0167718 (2016)

GLP-1 and glucagon regulate glucose metabolism through a network of metabolic pathways initiated upon binding to their specific receptors that belong to class B G-protein coupled receptors (GPCRs). The therapeutic potential of glucagon is currently b

Externí odkaz: https://doaj.org/article/d78ac03b22e4405799c2bd3400cf99bc

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Akademický článek

Multiple SNPs in intron 41 of thyroglobulin gene are associated with autoimmune thyroid disease in the Japanese population.

Autor: Yoshiyuki Ban, Teruaki Tozaki, Matsuo Taniyama, Luce Skrabanek, Yasuko Nakano, Yoshio Ban, Tsutomu Hirano

Publikováno v: PLoS ONE, Vol 7, Iss 5, p e37501 (2012)

BACKGROUND: The etiology of the autoimmune thyroid diseases (AITDs), Graves' disease (GD) and Hashimoto's thyroiditis (HT), is largely unknown. However, genetic susceptibility is believed to play a major role. Two whole genome scans from Japan and fr

Externí odkaz: https://doaj.org/article/51077832a1d54d628541dcf8385cfe08

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Novel Variant of Thyroglobulin Promoter Triggers Thyroid Autoimmunity through an Epigenetic Interferon α-modulated Mechanism

Autor: Mohammed Fadlalla, David A. Greenberg, Cheuk Wun Li, Yaron Tomer, Eric M. Jacobson, Kenneth Ho, Mihaela Stefan, Amanda K. Huber, Luce Skrabanek, Erlinda Conception

Publikováno v: Journal of Biological Chemistry. 286:31168-31179

Autoimmune thyroid diseases (AITD) arise from complex interactions between genetic, epigenetic, and environmental factors. Whole genome linkage scans and association studies have established thyroglobulin (TG) as a major AITD susceptibility gene. How

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5559b5b41bf19b41ca552c6f20b2081
https://doi.org/10.1074/jbc.m111.247510

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Multiple SNPs in intron 41 of thyroglobulin gene are associated with autoimmune thyroid disease in the Japanese population

Autor: Yasuko Nakano, Tsutomu Hirano, Luce Skrabanek, Teruaki Tozaki, Yoshio Ban, Matsuo Taniyama, Yoshiyuki Ban

Publikováno v: PLoS ONE, Vol 7, Iss 5, p e37501 (2012)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f041a40f26174ebb60849b40283af686
http://europepmc.org/articles/PMC3360768?pdf=render

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Employing a recombinant HLA-DR3 expression system to dissect major histocompatibility complex II-thyroglobulin peptide dynamism: a genetic, biochemical, and reverse immunological perspective

Autor: Eric M, Jacobson, Heyi, Yang, Francesca, Menconi, Rong, Wang, Roman, Osman, Luce, Skrabanek, Cheuk Wun, Li, Mohammed, Fadlalla, Alisha, Gandhi, Vijaya, Chaturvedi, Eric P, Smith, Sandy, Schwemberger, Andrew, Osterburg, George F, Babcock, Yaron, Tomer

Publikováno v: The Journal of biological chemistry. 284(49)

Previously, we have shown that statistical synergism between amino acid variants in thyroglobulin (Tg) and specific HLA-DR3 pocket sequence signatures conferred a high risk for autoimmune thyroid disease (AITD). Therefore, we hypothesized that this s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a7073c24a9ff3d554b32a3b58b8014e2
https://pubmed.ncbi.nlm.nih.gov/19776016

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