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pro vyhledávání: '"Lucca Gianni"'
Autor:
Jean-Luc Van Laethem, Christiana Sessa, Kunihiro Yoshisue, Anastasios Stathis, Angelica Fasolo, Lucca Gianni, Alberto Sobrero, Jean-Charles Soria, Antoine Hollebecque, Takekazu Aoyama
Publikováno v:
Cancer Research. 78:CT014-CT014
Background: Deoxyuridine triphosphatase (dUTPase) is the key gatekeeper enzyme that inhibits 5-fluorouracil (5-FU) misincorporation into DNA in tumor cells, and its overexpression is associated with resistance to 5-FU-based chemotherapy.1 TAS-114 is