Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Lucas van Duin"'
Publikováno v:
Molecular Systems Biology, Vol 19, Iss 7, Pp 1-17 (2023)
Abstract Many genes are co‐expressed and form genomic domains of coordinated gene activity. However, the regulatory determinants of domain co‐activity remain unclear. Here, we leverage human individual variation in gene expression to characterize
Externí odkaz:
https://doaj.org/article/c0ff0e72b3834be1a2a4a6dc42af6a37
Autor:
Iveta Gažová, Lucas Lefevre, Stephen J. Bush, Sara Clohisey, Erik Arner, Michiel de Hoon, Jessica Severin, Lucas van Duin, Robin Andersson, Andreas Lengeling, David A. Hume, Kim M. Summers
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
The response of the human acute myeloid leukemia cell line THP-1 to phorbol esters has been widely studied to test candidate leukemia therapies and as a model of cell cycle arrest and monocyte-macrophage differentiation. Here we have employed Cap Ana
Externí odkaz:
https://doaj.org/article/7200a6989408462ca37702c78fd14d54
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Transcriptional regulation is coupled with chromosomal positioning and chromatin architecture. Here the authors develop a transcriptional decomposition approach to separate expression associated with genome structure from independent effects not dire
Externí odkaz:
https://doaj.org/article/8fba3c63d1ce45de95bd48d281f5b53b
Autor:
Lucas Lefevre, Kim M. Summers, Iveta Gažová, Jessica Severin, Michiel J. L. de Hoon, Andreas Lengeling, David A. Hume, Stephen J. Bush, Sara Clohisey, Erik Arner, Robin Andersson, Lucas van Duin
Publikováno v:
Frontiers in Cell and Developmental Biology
Gazova, I, Lefevre, L, Bush, S J, Clohisey, S, Arner, E, de Hoon, M, Severin, J, van Duin, L, Andersson, R, Lengeling, A, Hume, D A & Summers, K M 2020, ' The Transcriptional Network That Controls Growth Arrest and Macrophage Differentiation in the Human Myeloid Leukemia Cell Line THP-1 ', Frontiers in Cell and Developmental Biology, vol. 8, 498 . https://doi.org/10.3389/fcell.2020.00498
Gazova, I, Lefevre, L, Bush, S J, Clohisey, S, Arner, E, de Hoon, M J, Severin, J, Duin, L V, Andersson, R, Lengeling, A, Hume, D & Summers, K 2020, ' The Transcriptional Network that Controls Growth Arrest and Macrophage Differentiation in the Human Myeloid Leukemia Cell Line THP-1 ', Frontiers in Cell and Developmental Biology . https://doi.org/10.3389/fcell.2020.00498
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Gazova, I, Lefevre, L, Bush, S J, Clohisey, S, Arner, E, de Hoon, M, Severin, J, van Duin, L, Andersson, R, Lengeling, A, Hume, D A & Summers, K M 2020, ' The Transcriptional Network That Controls Growth Arrest and Macrophage Differentiation in the Human Myeloid Leukemia Cell Line THP-1 ', Frontiers in Cell and Developmental Biology, vol. 8, 498 . https://doi.org/10.3389/fcell.2020.00498
Gazova, I, Lefevre, L, Bush, S J, Clohisey, S, Arner, E, de Hoon, M J, Severin, J, Duin, L V, Andersson, R, Lengeling, A, Hume, D & Summers, K 2020, ' The Transcriptional Network that Controls Growth Arrest and Macrophage Differentiation in the Human Myeloid Leukemia Cell Line THP-1 ', Frontiers in Cell and Developmental Biology . https://doi.org/10.3389/fcell.2020.00498
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
The response of the human acute myeloid leukemia cell line THP-1 to phorbol esters has been widely-studied to test candidateleukemia therapies and as a model of cell cycle arrest and monocyte-macrophage differentiation. Here we have employed CapAnaly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2e9cae35368dec2aba93fafb4041bd8
https://pubmed.ncbi.nlm.nih.gov/32719792
https://pubmed.ncbi.nlm.nih.gov/32719792
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature Communications
Rennie, S, Dalby, M, van Duin, L & Andersson, R 2018, ' Transcriptional decomposition reveals active chromatin architectures and cell specific regulatory interactions ', Nature Communications, vol. 9, 487 . https://doi.org/10.1038/s41467-017-02798-1
Nature Communications
Rennie, S, Dalby, M, van Duin, L & Andersson, R 2018, ' Transcriptional decomposition reveals active chromatin architectures and cell specific regulatory interactions ', Nature Communications, vol. 9, 487 . https://doi.org/10.1038/s41467-017-02798-1
Transcriptional regulation is tightly coupled with chromosomal positioning and three-dimensional chromatin architecture. However, it is unclear what proportion of transcriptional activity is reflecting such organisation, how much can be informed by R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f46d125ba3bf347c1dce6a4e4b4de7c7
