Zobrazeno 1 - 10 of 19 pro vyhledávání: '"Lucas Wahl"'
1
Akademický článek
Multiparametric Assays Capture Sex- and Environment-Dependent Modifiers of Behavioral Phenotypes in Autism Mouse Models
Autor: Lucas Wahl, Arun Karim, Amy R. Hassett, Max van der Doe, Stephanie Dijkhuizen, Aleksandra Badura
Publikováno v: Biological Psychiatry Global Open Science, Vol 4, Iss 6, Pp 100366- (2024)
Background: Current phenotyping approaches for murine autism models often focus on one selected behavioral feature, making the translation onto a spectrum of autistic characteristics in humans challenging. Furthermore, sex and environmental factors a
Externí odkaz: https://doaj.org/article/2cecd1b0a7fa473383f1e12ccdec50fb
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2
Akademický článek
Activated PI3Kδ syndrome, an immunodeficiency disorder, leads to sensorimotor deficits recapitulated in a murine model
Autor: Ines Serra, Olivia R. Manusama, Fabian M.P. Kaiser, Izi Izumi Floriano, Lucas Wahl, Christian van der Zalm, Hanna IJspeert, P. Martin van Hagen, Nico J.M. van Beveren, Sandra M. Arend, Klaus Okkenhaug, Johan J.M. Pel, Virgil A.S.H. Dalm, Aleksandra Badura
Publikováno v: Brain, Behavior, & Immunity - Health, Vol 18, Iss , Pp 100377- (2021)
The phosphoinositide-3-kinase (PI3K) family plays a major role in cell signaling and is predominant in leukocytes. Gain-of-function (GOF) mutations in the PIK3CD gene lead to the development of activated PI3Kδ syndrome (APDS), a rare primary immunod
Externí odkaz: https://doaj.org/article/27d8b652350244c4b767f51c4c9d81e3
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4
Biallelic PAX5 mutations cause hypogammaglobulinemia, sensorimotor deficits, and autism spectrum disorder
Autor: Fabian M.P. Kaiser, Sarah Gruenbacher, Maria Roa Oyaga, Enzo Nio, Markus Jaritz, Qiong Sun, Wietske van der Zwaag, Emanuel Kreidl, Lydia M. Zopf, Virgil A.S.H. Dalm, Johan Pel, Carolin Gaiser, Rick van der Vliet, Lucas Wahl, André Rietman, Louisa Hill, Ines Leca, Gertjan Driessen, Charlie Laffeber, Alice Brooks, Peter D. Katsikis, Joyce H.G. Lebbink, Kikuë Tachibana, Mirjam van der Burg, Chris I. De Zeeuw, Aleksandra Badura, Meinrad Busslinger
Publikováno v: Journal of Experimental Medicine, 219(9). ROCKEFELLER UNIV PRESS
Journal of Experimental Medicine, 219(9). Rockefeller University Press
Journal of Experimental Medicine, 219(9):e20220498. Rockefeller University Press
The genetic causes of primary antibody deficiencies and autism spectrum disorder (ASD) are largely unknown. Here, we report a patient with hypogammaglobulinemia and ASD who carries biallelic mutations in the transcription factor PAX5. A patient-speci
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0c45534b870443c148751c0cebb9e1b
https://doi.org/10.1084/jem.20220498
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5
Activated PI3Kδ syndrome, an immunodeficiency disorder, leads to sensorimotor deficits recapitulated in a murine model
Autor: Sandra M. Arend, Izi Izumi Floriano, P. Martin van Hagen, Aleksandra Badura, Ines Serra, Johan J.M. Pel, Olivia R. Manusama, Virgil A. S. H. Dalm, Fabian M.P. Kaiser, Christian van der Zalm, Klaus Okkenhaug, Nico J.M. van Beveren, Hanna IJspeert, Lucas Wahl
Publikováno v: Brain, Behavior, & Immunity-Health, Vol 18, Iss, Pp 100377-(2021)
Brain, behavior, & immunity-health, 18:100377. Elsevier Inc.
Brain, Behavior, & Immunity-Health
The phosphoinositide-3-kinase (PI3K) family plays a major role in cell signalling and is predominant in leukocytes. Gain-of-function (GOF) mutations in the PIK3CD gene lead to the development of activated PI3Kδ syndrome (APDS), a rare primary immuno
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef066d6af7eda61a9ddca19fb022ef35
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