Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Lucas W. Hernandez"'
Autor:
Veronique Mathieu, Breana Laguera, Marco Masi, Sara Adriana Dulanto, Tanner W. Bingham, Lucas W. Hernandez, David Sarlah, Antonio Evidente, Denis L. J. Lafontaine, Alexander Kornienko, Michelle A. Lane
Publikováno v:
Biomolecules, Vol 12, Iss 9, p 1267 (2022)
Alkaloids isolated from members of the Amaryllidaceae plant family are promising anticancer agents. The purpose of the current study was to determine if the isocarbostyrils narciclasine, pancratistatin, lycorane, lycorine, crinane, and haemanthamine
Externí odkaz:
https://doaj.org/article/b9b5ab1ef3e34de6aeefbfe47a867b39
Publikováno v:
Journal of the American Chemical Society. 145:8805-8809
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39cc1eab7d5510b43083636eb35139f4
https://doi.org/10.1021/jacs.3c02317
https://doi.org/10.1021/jacs.3c02317
Publikováno v:
Organic Letters. 22:5953-5957
Chiral phosphoric-acid-catalyzed asymmetric reductions of trans-chalcones have been investigated in this work. A BINOL-derived boro-phosphate-catalyzed asymmetric transfer hydrogenation of the carb...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23b87477d05a831b1a6af6bd596a24d9
https://doi.org/10.1021/acs.orglett.0c02042
https://doi.org/10.1021/acs.orglett.0c02042
Autor:
Francisco González-Bobes, John R. Coombs, Lucas W. Hernandez, William P. Gallagher, Carlos A. Guerrero
Publikováno v:
The Journal of organic chemistry. 86(15)
The use of sodium dithionite with perfluoroalkyl iodides under basic conditions facilitates the direct perfluoroalkylation of arenes with pendant benzylic electron-withdrawing groups. This occurs via attack of the arene on the electrophilic perfluoro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe8ce6fba0f803e4c7dc82e575aeb034
https://pubmed.ncbi.nlm.nih.gov/34286987
https://pubmed.ncbi.nlm.nih.gov/34286987
Publikováno v:
Strategies and Tactics in Organic Synthesis ISBN: 9780128222126
The highly potent anticancer natural products, the Amaryllidaceae isocarbostyril alkaloids, have been a desirable target for total synthesis over the past few decades. However, while many elegant approaches have been reported previously, scalable acc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::920f86877f628e6e6e31b3982bc7f213
https://doi.org/10.1016/b978-0-12-822212-6.00004-7
https://doi.org/10.1016/b978-0-12-822212-6.00004-7
Autor:
Fei, Na, Susana S, Lopez, Alice, Beauseigneur, Lucas W, Hernandez, Zhuoxin, Sun, Jon C, Antilla
Publikováno v:
Organic letters. 22(15)
Chiral phosphoric-acid-catalyzed asymmetric reductions of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0a54704221bfbd7f5b145ba8c523c621
https://pubmed.ncbi.nlm.nih.gov/32692927
https://pubmed.ncbi.nlm.nih.gov/32692927
Autor:
David Sarlah, Lucas W. Hernandez
Publikováno v:
Chemistry – A European Journal. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1641da52844ec337e7d894deec034d3a
https://doi.org/10.1002/chem.201985862
https://doi.org/10.1002/chem.201985862
Autor:
David Sarlah, Lucas W. Hernandez
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 25(58)
Synthesis of natural products remains a daring task. Their richly diverse and intricate structures often encompass a large degree of unsaturation, contain fused and/or bridged rings, or possess numerous stereogenic centers. Thus, their preparation re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1f06bd11a7b2876805b594d2b8f868f
https://pubmed.ncbi.nlm.nih.gov/31194262
https://pubmed.ncbi.nlm.nih.gov/31194262
Autor:
Riley L. Svec, Daniel G. Olson, Tanner W. Bingham, Paul J. Hergenrother, David Sarlah, Lucas W. Hernandez
Enantioselective total syntheses of the anticancer isocarbostyril alkaloids (+)-7-deoxypancratistatin, (+)-pancratistatin, (+)-lycoricidine, and (+)-narciclasine are described. Our strategy for accessing this unique class of natural products is based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::161733701d39650a56d6eb0a6be28503
https://europepmc.org/articles/PMC6488038/
https://europepmc.org/articles/PMC6488038/
Publikováno v:
Journal of the American Chemical Society. 140(13)
We describe the development of an arenophile-mediated, nickel-catalyzed dearomative trans-1,2-carboamination protocol. A range of readily available aromatic compounds was converted to the corresponding dienes using Grignard reagents as nucleophiles.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68ba56d7faba8293525e1db25af4999c
https://pubmed.ncbi.nlm.nih.gov/29544244
https://pubmed.ncbi.nlm.nih.gov/29544244