Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Lucas T. Gray"'
Publikováno v:
eLife, Vol 6 (2017)
Mammalian cortex is a laminar structure, with each layer composed of a characteristic set of cell types with different morphological, electrophysiological, and connectional properties. Here, we define chromatin accessibility landscapes of major, laye
Externí odkaz:
https://doaj.org/article/b6160fb46d964729b7ea8e63a8ca54b5
Autor:
Nancy Maizels, Lucas T Gray
Publikováno v:
PLoS Genetics, Vol 9, Iss 4, p e1003468 (2013)
Recent experiments provide fascinating examples of how G4 DNA and G4 RNA structures--aka quadruplexes--may contribute to normal biology and to genomic pathologies. Quadruplexes are transient and therefore difficult to identify directly in living cell
Externí odkaz:
https://doaj.org/article/832d0c6a48a543f786436e675887599f
Autor:
Nancy Maizels, Emilia Puig Lombardi, Alain Nicolas, Daniela Verga, Lucas T. Gray, Marie-Paule Teulade-Fichou, Arturo Londoño-Vallejo
Publikováno v:
Cell Chemical Biology
Cell Chemical Biology, Cell Press, 2019, ⟨10.1016/j.chembiol.2019.10.003⟩
Cell Chemical Biology, Cell Press, 2019, 26 (12), pp.1681-1691.e5. ⟨10.1016/j.chembiol.2019.10.003⟩
Cell Chemical Biology, Cell Press, 2019, ⟨10.1016/j.chembiol.2019.10.003⟩
Cell Chemical Biology, Cell Press, 2019, 26 (12), pp.1681-1691.e5. ⟨10.1016/j.chembiol.2019.10.003⟩
Heme is an essential cofactor for many enzymes, but free heme is toxic and its levels are tightly regulated. G-quadruplexes bind heme avidlyin vitro, raising the possibility that they may sequester hemein vivo. If so, then treatment that displaces he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24cc992ce0d8df2d766272582c46c879
https://doi.org/10.1101/652297
https://doi.org/10.1101/652297
Autor:
Linda Madisen, Kimberly A. Smith, Darren Bertagnolli, Amy Bernard, Tim Jarsky, Jeff Goldy, Tim A. Dolbeare, Hongkui Zeng, Lucas T. Gray, Christof Koch, Tae Kyung Kim, Susan M. Sunkin, Boaz P. Levi, Changkyu Lee, Bosiljka Tasic, Nadiya V. Shapovalova, Zizhen Yao, Michael Hawrylycz, Staci A. Sorensen, Thuc Nghi Nguyen, Sheana Parry, Vilas Menon
Publikováno v:
Nature neuroscience
Nervous systems are composed of various cell types, but the extent of cell type diversity is poorly understood. We constructed a cellular taxonomy of one cortical region, primary visual cortex, in adult mice on the basis of single-cell RNA sequencing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc6a2809a0ab068684746c992cbd6541
http://europepmc.org/articles/PMC4985242
http://europepmc.org/articles/PMC4985242
Autor:
Trygve E. Bakken, Rebecca D. Hodge, Jeremy M. Miller, Zizhen Yao, Thuc N. Nguyen, Brian Aevermann, Eliza Barkan, Darren Bertagnolli, Tamara Casper, Nick Dee, Emma Garren, Jeff Goldy, Lucas T. Gray, Matthew Kroll, Roger S. Lasken, Kanan Lathia, Sheana Parry, Christine Rimorin, Richard H. Scheuermann, Nicholas J. Schork, Soraya I. Shehata, Michael Tieu, John W. Phillips, Amy Bernard, Kimberly A. Smith, Hongkui Zeng, Ed S. Lein, Bosiljka Tasic
Transcriptional profiling of complex tissues by RNA-sequencing of single nuclei presents some advantages over whole cell analysis. It enables unbiased cellular coverage, lack of cell isolation-based transcriptional effects, and application to archive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::078c25a4d6681ca203a42d857f0bc437
https://doi.org/10.1101/239749
https://doi.org/10.1101/239749
Autor:
Suhas V. Vasaikar, Adam K. Savage, Qiuyu Gong, Elliott Swanson, Aarthi Talla, Cara Lord, Alexander T. Heubeck, Julian Reading, Lucas T. Graybuck, Paul Meijer, Troy R. Torgerson, Peter J. Skene, Thomas F. Bumol, Xiao-jun Li
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
The analysis of longitudinal bulk and single-cell multi-omics data is a highly complex task. Here, the authors introduce PALMO, a software platform with five modules to analyse longitudinal bulk and single-cell multi-omics data, which is extensively
Externí odkaz:
https://doaj.org/article/9167378588ad444cbf7f985a5e41ce2a
Publikováno v:
eLife, Vol 6 (2017)
eLife
eLife
Mammalian cortex is a laminar structure, with each layer composed of a characteristic set of cell types with different morphological, electrophysiological, and connectional properties. Here, we define chromatin accessibility landscapes of major, laye
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5745e06d40e3d7995ecf817f3d518051
https://elifesciences.org/articles/21883
https://elifesciences.org/articles/21883
Publikováno v:
Nature chemical biology
G4 motifs are greatly enriched near promoters, suggesting that quadruplex structures may be targets of transcriptional regulation. Here we show, by ChIP-Seq analysis of human cells, that 40% of the binding sites of the transcription-associated helica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa06de0aa9d0d243ca81dcf8390c1ee4
https://doi.org/10.1038/nchembio.1475
https://doi.org/10.1038/nchembio.1475
Autor:
Lucas T. Gray, Junko Oshima, Raymond J. Monnat, Weiliang Tang, Richard P. Beyer, Nancy Maizels, Curtis C. Harris, Ana I. Robles, Giang Nguyen
The Werner syndrome (WS) is a prototypic adult Mendelian progeroid syndrome in which signs of premature aging are associated with genomic instability and an elevated risk of cancer. The WRN RECQ helicase protein binds and unwinds G-quadruplex (G4) DN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::206c86ea7f80929f9371862f481ac6e7
https://europepmc.org/articles/PMC5062591/
https://europepmc.org/articles/PMC5062591/