Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Lucas Showman"'
Autor:
Suraj S. Vasanthi, Nikhil S. Rao, Manikandan Samidurai, Nyzil Massey, Christina Meyer, Meghan Gage, Mihir Kharate, Aida Almanza, Logan Wachter, Candide Mafuta, Lily Trevino, Adriana M. Carlo, Elijah Bryant, Brooke E. Corson, Morgan Wohlgemuth, Morgan Ostrander, Lucas Showman, Chong Wang, Thimmasettappa Thippeswamy
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-25 (2023)
Abstract Background Acute exposure to seizurogenic organophosphate (OP) nerve agents (OPNA) such as diisopropylfluorophosphate (DFP) or soman (GD), at high concentrations, induce immediate status epilepticus (SE), reactive gliosis, neurodegeneration,
Externí odkaz:
https://doaj.org/article/27b5448e94704f1a86180ed9deaf58b0
Autor:
Suraj S. Vasanthi, Nyzil Massey, Suresh N. Nair, Jonathan P. Mochel, Lucas Showman, Thimmasettappa Thippeswamy
Publikováno v:
Frontiers in Veterinary Science, Vol 10 (2023)
Saracatinib/AZD0530 (SAR), a Src tyrosine kinase inhibitor, mitigates seizure-induced brain pathology in epilepsy models upon repeated oral dosing. However, repeated dosing is stressful and can be challenging in some seizing animals. To overcome this
Externí odkaz:
https://doaj.org/article/7c514cee98144e1db9ae0052e453e9fa
Autor:
Christina Meyer, Elizabeth Grego, Suraj S. Vasanthi, Nikhil S. Rao, Nyzil Massey, Claire Holtkamp, Joselyn Huss, Lucas Showman, Balaji Narasimhan, Thimmasettappa Thippeswamy
Publikováno v:
Antioxidants, Vol 12, Iss 12, p 2061 (2023)
NADPH oxidase (NOX) is a primary mediator of superoxides, which promote oxidative stress, neurodegeneration, and neuroinflammation after diisopropylfluorophosphate (DFP) intoxication. Although orally administered mitoapocynin (MPO, 10 mg/kg), a mitoc
Externí odkaz:
https://doaj.org/article/331dd32870e5452ba3ebce96b8785c24
Autor:
Zoë E. Kiefer, Lucas R. Koester, Lucas Showman, Jamie M. Studer, Amanda L. Chipman, Aileen F. Keating, Stephan Schmitz-Esser, Jason W. Ross
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Sow mortality attributable to pelvic organ prolapse (POP) has increased in the U.S. swine industry and continues to worsen. Two main objectives of this study were, (1) to develop a perineal scoring system that can be correlated with POP risk
Externí odkaz:
https://doaj.org/article/b17f384238d34d99ab4a7d5b5553a3b7
Autor:
Akhil A. Vinithakumari, Piyush Padhi, Belen Hernandez, Susanne Je-Han Lin, Aaron Dunkerson-Kurzhumov, Lucas Showman, Matthew Breitzman, Caroline Stokes, Yousuf Sulaiman, Chandra Tangudu, Deepa A. Kuttappan, Muhammed S. Muyyarikkandy, Auriel A. Willette, Gregory J. Phillips, Vellareddy Anantharam, Ann Perera, Brett A. Sponseller, Anumantha Kanthasamy, Shankumar Mooyottu
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 2 (2022)
ABSTRACT Gastrointestinal illnesses and dysbiosis are among the most common comorbidities reported in patients with neurodevelopmental disorders. The manuscript reports that C. difficile infection (CDI), predisposed by antibiotic-induced gut dysbiosi
Externí odkaz:
https://doaj.org/article/fb5467f09f994869bde21d4f5bb97ce9
Autor:
Shaunik Sharma, Steven Carlson, Sreekanth Puttachary, Souvarish Sarkar, Lucas Showman, Marson Putra, Anumantha G. Kanthasamy, Thimmasettappa Thippeswamy
Publikováno v:
Neurobiology of Disease, Vol 110, Iss , Pp 102-121 (2018)
Status epilepticus (SE) induces neuroinflammation and epileptogenesis, but the mechanisms are not yet fully delineated. The Fyn, a non-receptor Src family tyrosine kinase (SFK), and its immediate downstream target, PKCδ are emerging as potential med
Externí odkaz:
https://doaj.org/article/64a5d7332d2b4d7f80a283ceb395d464
Autor:
Stephan Schmitz-Esser, Lucas Showman, Amanda Chipman, Jamie M Studer, Aileen F. Keating, Lucas R. Koester, Zoe E Kiefer, Jason W. Ross
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports
Scientific Reports
Sow mortality attributable to pelvic organ prolapse (POP) has increased in the U.S. swine industry and continues to worsen. Two main objectives of this study were, (1) to develop a perineal scoring system that can be correlated with POP risk, and (2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e4dfde74bae3c47180e6a13d2dff5bd
https://doaj.org/article/b17f384238d34d99ab4a7d5b5553a3b7
https://doaj.org/article/b17f384238d34d99ab4a7d5b5553a3b7
Publikováno v:
Frontiers in Plant Science, Vol 12 (2021)
Sterols are integral components of membrane lipid bilayers in eukaryotic organisms and serve as precursors to steroid hormones in vertebrates and brassinosteroids (BR) in plants. In vertebrates, cholesterol is the terminal sterol serving both indirec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e45fcada258eae4f8db63fdff517875
https://doi.org/10.3389/fpls.2021.732216
https://doi.org/10.3389/fpls.2021.732216
Autor:
Geoffrey Paul Horst, Farrah C Phillips, Robert B. Levine, Rachel Tonda, Lucas Showman, Gitte S. Jensen
Publikováno v:
Journal of Inflammation Research. 12:49-64
Purpose The purpose of this work was to determine the pro-and anti-inflammatory properties of the single-cell organism Euglena gracilis (EG) and various fractions of its whole biomass. Methods Heterotrophically grown EG was tested, along with its aqu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ffcefe75a18baa2f53209c109c8c55e
https://doi.org/10.2147/jir.s191824
https://doi.org/10.2147/jir.s191824
Publikováno v:
Environmental and Experimental Botany. 156:214-227
Freezing tolerance and metabolome changes were investigated for spinach (Spinacia oleracea L. ‘Reflect’) seedlings treated with 0.5 mM salicylic acid by sub-fertigation. Experiments included seedlings treated with salicylic acid at both the ambie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0876ffea80598c5e07e695ba54677f08
https://doi.org/10.1016/j.envexpbot.2018.09.011
https://doi.org/10.1016/j.envexpbot.2018.09.011