Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Lucas S. Shores"'
Autor:
Lucas S. Shores, Sean H. Kelly, Kelly M. Hainline, Jutamas Suwanpradid, Amanda S. MacLeod, Joel H. Collier
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Current treatments for chronic immune-mediated diseases such as psoriasis, rheumatoid arthritis, or Crohn's disease commonly rely on cytokine neutralization using monoclonal antibodies; however, such approaches have drawbacks. Frequent repeated dosin
Externí odkaz:
https://doaj.org/article/c6819c39d3dd4406b18e8b2ec0fffa54
Autor:
Shijie Cao, Erica Budina, Michal M. Raczy, Ani Solanki, Mindy Nguyen, Kevin Hultgren, Phillip Ang, Joseph W. Reda, Lucas S. Shores, Ishita Pillai, Rachel P. Wallace, Arjun Dhar, Elyse A. Watkins, Jeffrey A. Hubbell
Butyrate, a metabolite produced by commensal bacteria, has been intensively studied for its immunomodulatory effects on various immune cells, including T regulatory cells, macrophages, and dendritic cells. Butyrate’s development as a drug has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77fc50ad778a74748e88ff33f6181902
https://doi.org/10.1101/2023.04.28.538720
https://doi.org/10.1101/2023.04.28.538720
Autor:
Sean H. Kelly, Nicole L. Votaw, Benjamin J. Cossette, Yaoying Wu, Shamitha Shetty, Lucas S. Shores, Luqman A. Issah, Joel H. Collier
Publikováno v:
Science Advances. 8
Urinary tract infections (UTIs) are a major public health problem affecting millions of individuals each year. Recurrent UTIs are managed by long-term antibiotic use, making the alarming rise of antibiotic resistance a substantial threat to future UT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0021db2c15639ff9e35360663faa884b
https://doi.org/10.1126/sciadv.abq4120
https://doi.org/10.1126/sciadv.abq4120
Autor:
Weimin Zhang, Luciana Lazar-Stefanita, Hitoyoshi Yamashita, Michael J. Shen, Leslie A. Mitchell, Hikaru Kurasawa, Max A. B. Haase, Xiaoji Sun, Qingwen Jiang, Stephanie L. Lauer, Laura H. McCulloch, Yu Zhao, David Ichikawa, Nicole Easo, S. Jiaming Lin, Viola Fanfani, Brendan R. Camellato, Yinan Zhu, Jitong Cai, Zhuwei Xu, Maya Sacasa, Ryan Accardo, Ju Young Ahn, Surekha Annadanam, Leighanne A. Brammer Basta, Nicholas R. Bello, Lousanna Cai, Stephanie Cerritos, MacIntosh Cornwell, Anthony D’Amato, Maria Hacker, Kenneth Hersey, Emma Kennedy, Ardeshir Kianercy, Dohee Kim, Hong Seo Lim, Griffin McCutcheon, Kimiko McGirr, Nora Meaney, Lauren Meyer, Ally Moyer, Maisa Nimer, Carla Sabbatini, Lisa Scheifele, Lucas S. Shores, Cassandra Silvestrone, Arden Snee, Antonio Spina, Anthony Staiti, Matt Stuver, Elli Tian, Danielle Whearty, Calvin Zhao, Tony Zheng, Vivian Zhou, Karen Zeller, Joel S. Bader, Giovanni Stracquadanio, Samuel Deutsch, Junbiao Dai, Yasunori Aizawa, Jef D. Boeke
SummaryWhether synthetic genomes can power life has attracted broad interest in the synthetic biology field, especially when the synthetic genomes are extensively modified with thousands of designer features. Here we report de novo synthesis of the l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45f6dbba20f40851fd5c93f58596588a
https://doi.org/10.1101/2022.04.09.487066
https://doi.org/10.1101/2022.04.09.487066
Autor:
Marisha S Madhira, Lucas S. Shores, Nicole L. Votaw, Sean H. Kelly, Joel H. Collier, Caslin A. Gilroy, Kelly M. Hainline, Zachary J Bernstein, Chelsea N. Fries, Ashutosh Chilkoti
Publikováno v:
Proc Natl Acad Sci U S A
Complement protein C3dg, a key linkage between innate and adaptive immunity, is capable of stimulating both humoral and cell-mediated immune responses, leading to considerable interest in its use as a molecular adjuvant. However, the potential of C3d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13f28abb36b0581abddc0387c1c7cdd8
https://pubmed.ncbi.nlm.nih.gov/33876753
https://pubmed.ncbi.nlm.nih.gov/33876753
Autor:
Qiaomu Tian, Joel H. Collier, Sean H. Kelly, Anita S. Chong, Daniel F. Camacho, Lucas S. Shores, Michael S. Andrade, Anne I. Sperling, Fan Zhao, Youhui Si
Publikováno v:
Science Advances. 6
The current paradigm that subunit vaccines require adjuvants to optimally activate innate immunity implies that increased vaccine reactogenicity will invariably be linked to improved immunogenicity. Countering this paradigm, nanoparticulate vaccines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dcebffcdc81c2b8fb917ac2bc1bb9db2
https://doi.org/10.1126/sciadv.aba0995
https://doi.org/10.1126/sciadv.aba0995
Publikováno v:
Advanced Drug Delivery Reviews. 114:3-18
Biomaterials employed to raise therapeutic immune responses have become a complex and active field. Historically, vaccines have been developed primarily to fight infectious diseases, but recent years have seen the development of immunologically activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c14654bab683d84441eefb05f360028
https://doi.org/10.1016/j.addr.2017.04.009
https://doi.org/10.1016/j.addr.2017.04.009
Autor:
Youhui, Si, Qiaomu, Tian, Fan, Zhao, Sean H, Kelly, Lucas S, Shores, Daniel F, Camacho, Anne I, Sperling, Michael S, Andrade, Joel H, Collier, Anita S, Chong
Publikováno v:
Science Advances
Intranasal Q11 nanofiber vaccination activates lung dendritic cell antigen presentation and TH17 priming in both lung and lymph nodes.
The current paradigm that subunit vaccines require adjuvants to optimally activate innate immunity implies tha
The current paradigm that subunit vaccines require adjuvants to optimally activate innate immunity implies tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::131e4a80cdb42cf5202bf0bf90c4adef
https://pubmed.ncbi.nlm.nih.gov/32821819
https://pubmed.ncbi.nlm.nih.gov/32821819
Local delivery of a carbohydrate analog for reducing arthritic inflammation and rebuilding cartilage
Autor:
Chaekyu Kim, Rahul Bhattacharya, Jennifer H. Elisseeff, Nicholas Bernstein, Jeannine M. Coburn, Lucas S. Shores, Je-Min Chae, Ok-Hee Jeon, Kevin J. Yarema, Do Hun Kim
Publikováno v:
Biomaterials
Osteoarthritis (OA) is a degenerative joint disease characterized by articular cartilage degradation. Because OA has a multifactorial nature and complex interrelationship of the individual elements of a whole joint, there is a need for comprehensive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ba2ed7ddfa0b0ea3964b83bd170cf89
https://doi.org/10.1016/j.biomaterials.2015.12.029
https://doi.org/10.1016/j.biomaterials.2015.12.029
Autor:
Ga Hye Kim, Meera Ramakrishnan, Qiaozhi Lu, Qiongyu Guo, Lucas S. Shores, Shuqing Yang, Ahmed Aly, Jennifer H. Elisseeff, Lixin Su
Publikováno v:
Journal of Biomedical Materials Research Part A. 103:235-242
Replacement of autogenous or allograft bones by artificial graft materials represents a growing area of interest in current bone repair strategies. Bioactive ceramics in particulate form, such as Bioglass® (BG) 45S5, stimulate bone mineralization co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbfb23e9540132b5758e29c8bee51677
https://doi.org/10.1002/jbm.a.35143
https://doi.org/10.1002/jbm.a.35143