Zobrazeno 1 - 10
of 151
pro vyhledávání: '"Lucas R Hoffman"'
Autor:
Shailly Pandey, Kathryn B Whitlock, Matthew R Test, Paul Hodor, Christopher E Pope, David D Limbrick, Patrick J McDonald, Jason S Hauptman, Lucas R Hoffman, Tamara D Simon, Cerebrospinal FLuId MicroBiota in Shunts (CLIMB) Study Group
Publikováno v:
PLoS ONE, Vol 18, Iss 6, p e0280682 (2023)
ObjectiveTo characterize the microbiota of the cerebrospinal fluid (CSF) from children with hydrocephalus at the time of initial surgical intervention.Study designCSF was obtained at initial surgical intervention. One aliquot was stored in skim milk-
Externí odkaz:
https://doaj.org/article/9ae7add615f145ae94046a35321de8aa
Autor:
Kathryn B Whitlock, Christopher E Pope, Paul Hodor, Lucas R Hoffman, David L Limbrick, Patrick J McDonald, Jason S Hauptman, Jeffrey G Ojemann, Tamara D Simon, Cerebrospinal FLuId MicroBiota in Shunts Study (CLIMB) Group
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0244643 (2021)
BackgroundNearly 20% of patients with cerebrospinal fluid (CSF) shunt infection develop reinfection. It is unclear whether reinfections are caused by an organism previously present or are independent infection events.ObjectiveWe used bacterial cultur
Externí odkaz:
https://doaj.org/article/925348d470b6468f869e48db54759b07
Autor:
Joe J Harrison, Henrik Almblad, Yasuhiko Irie, Daniel J Wolter, Heather C Eggleston, Trevor E Randall, Jacob O Kitzman, Bethany Stackhouse, Julia C Emerson, Sharon Mcnamara, Tyler J Larsen, Jay Shendure, Lucas R Hoffman, Daniel J Wozniak, Matthew R Parsek
Publikováno v:
PLoS Genetics, Vol 16, Iss 6, p e1008848 (2020)
Pseudomonas aeruginosa colonizes the airways of cystic fibrosis (CF) patients, causing infections that can last for decades. During the course of these infections, P. aeruginosa undergoes a number of genetic adaptations. One such adaptation is the lo
Externí odkaz:
https://doaj.org/article/acbec44d4bbb4dbeb96f2b9bdc39b2fa
Autor:
Catherine R Armbruster, Calvin K Lee, Jessica Parker-Gilham, Jaime de Anda, Aiguo Xia, Kun Zhao, Keiji Murakami, Boo Shan Tseng, Lucas R Hoffman, Fan Jin, Caroline S Harwood, Gerard CL Wong, Matthew R Parsek
Publikováno v:
eLife, Vol 9 (2020)
Externí odkaz:
https://doaj.org/article/4fdbcf82b5d04bb4b59387c47ce58d61
Autor:
Stacey M Meeker, Kevin S Mears, Naseer Sangwan, Mitchell J Brittnacher, Eli J Weiss, Piper M Treuting, Nicholas Tolley, Christopher E Pope, Kyle R Hager, Anh T Vo, Jisun Paik, Charles W Frevert, Hillary S Hayden, Lucas R Hoffman, Samuel I Miller, Adeline M Hajjar
Publikováno v:
PLoS Pathogens, Vol 16, Iss 1, p e1008251 (2020)
Patients with cystic fibrosis (CF) have altered fecal microbiomes compared to those of healthy controls. The magnitude of this dysbiosis correlates with measures of CF gastrointestinal (GI) disease, including GI inflammation and nutrient malabsorptio
Externí odkaz:
https://doaj.org/article/a071568799924354a179ea30319fdea7
Autor:
Catherine R Armbruster, Calvin K Lee, Jessica Parker-Gilham, Jaime de Anda, Aiguo Xia, Kun Zhao, Keiji Murakami, Boo Shan Tseng, Lucas R Hoffman, Fan Jin, Caroline S Harwood, Gerard CL Wong, Matthew R Parsek
Publikováno v:
eLife, Vol 8 (2019)
The second messenger signaling molecule cyclic diguanylate monophosphate (c-di-GMP) drives the transition between planktonic and biofilm growth in many bacterial species. Pseudomonas aeruginosa has two surface sensing systems that produce c-di-GMP in
Externí odkaz:
https://doaj.org/article/c486becfeac94d42920e320488c004bc
Autor:
Lucas R Hoffman, Anthony R Richardson, Laura S Houston, Hemantha D Kulasekara, Willm Martens-Habbena, Mikkel Klausen, Jane L Burns, David A Stahl, Daniel J Hassett, Ferric C Fang, Samuel I Miller
Publikováno v:
PLoS Pathogens, Vol 6, Iss 1, p e1000712 (2010)
Microbes are subjected to selective pressures during chronic infections of host tissues. Pseudomonas aeruginosa isolates with inactivating mutations in the transcriptional regulator LasR are frequently selected within the airways of people with cysti
Externí odkaz:
https://doaj.org/article/d716eb49cbf2497fad19b06ad78fe11a
Autor:
Leah Cuthbertson, Alan W. Walker, Anna E. Oliver, Geraint B. Rogers, Damian W. Rivett, Thomas H. Hampton, Alix Ashare, J. Stuart Elborn, Anthony De Soyza, Mary P. Carroll, Lucas R. Hoffman, Clare Lanyon, Samuel M. Moskowitz, George A. O’Toole, Julian Parkhill, Paul J. Planet, Charlotte C. Teneback, Michael M. Tunney, Jonathan B. Zuckerman, Kenneth D. Bruce, Christopher J. van der Gast
Publikováno v:
Microbiome, Vol 8, Iss 1, Pp 1-13 (2020)
Abstract Background Chronic infection and concomitant airway inflammation is the leading cause of morbidity and mortality for people living with cystic fibrosis (CF). Although chronic infection in CF is undeniably polymicrobial, involving a lung micr
Externí odkaz:
https://doaj.org/article/9cf945cb5ee8440d8a2afcecf4936353
Autor:
Sarah Jane Schwarzenberg, Phuong T. Vu, Michelle Skalland, Lucas R. Hoffman, Christopher Pope, Daniel Gelfond, Michael R. Narkewicz, David P. Nichols, Sonya L. Heltshe, Scott H. Donaldson, Carla A. Frederick, Andrea Kelly, Jessica E. Pittman, Felix Ratjen, Margaret Rosenfeld, Scott D. Sagel, George M. Solomon, Michael S. Stalvey, John P. Clancy, Steven M. Rowe, Steven D. Freedman
Publikováno v:
Journal of Cystic Fibrosis. 22:282-289
Elexacaftor/tezacaftor/ivacaftor (ETI) improves pulmonary disease in people with cystic fibrosis (PwCF), but its effect on gastrointestinal symptoms, which also affect quality of life, is not clear.PROMISE is a 56-center prospective, observational st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e79d99c628d03d00d355a597ce8b465
https://doi.org/10.1016/j.jcf.2022.10.003
https://doi.org/10.1016/j.jcf.2022.10.003
Autor:
Robyn L. Marsh, Maria T. Nelson, Chris E. Pope, Amanda J. Leach, Lucas R. Hoffman, Anne B. Chang, Heidi C. Smith-Vaughan
Publikováno v:
Pneumonia, Vol 10, Iss 1, Pp 1-9 (2018)
Abstract Background Culture-independent sequencing methods are increasingly used to investigate the microbiota associated with human mucosal surfaces, including sites that have low bacterial load in healthy individuals (e.g. the lungs). Standard micr
Externí odkaz:
https://doaj.org/article/7e129652960543699ca20a7df458f6f4