Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Lucas P. Nacusi"'
Autor:
Janeen H Trembley, Gretchen M Unger, Vicci L Korman, Md Joynal Abedin, Lucas P Nacusi, Rachel I Vogel, Joel W Slaton, Betsy T Kren, Khalil Ahmed
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109970 (2014)
Protected and specific delivery of nucleic acids to malignant cells remains a highly desirable approach for cancer therapy. Here we present data on the physical and chemical characteristics, mechanism of action, and pilot therapeutic efficacy of a te
Externí odkaz:
https://doaj.org/article/8ba3a800ed764abfb326c8718b911d34
Autor:
Khalil Ahmed, Rachel Isaksson Vogel, Daniel P. Shaughnessy, Scott M. Dehm, Cheryl L. Zimmerman, Janeen H. Trembley, Gretchen M. Unger, Md. Joynal Abedin, Lucas P. Nacusi, Vicci L. Korman, Gloria A. Niehans, Yingming Li, Betsy T. Kren
Publikováno v:
Oncotarget
// Khalil Ahmed 1, 2, 3, 6, * , Betsy T. Kren 1, 2, 6, * , Md. Joynal Abedin 1, 2, * , Rachel I. Vogel 4, 6 , Daniel P. Shaughnessy 1, 2 , Lucas Nacusi 7 , Vicci L. Korman 7 , Yingming Li 2 , Scott M. Dehm 2, 3, 6 , Cheryl L. Zimmerman 5 , Gloria A.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::059e41f761bc5b8e7935224842b7f2fa
https://doi.org/10.18632/oncotarget.11442
https://doi.org/10.18632/oncotarget.11442
Autor:
Ji Lu, Travis Vander Steen, Farhad Kosari, Lucas P. Nacusi, Haojie Huang, George Vasmatzis, Lucy J. Schmidt, Peter E. Lonergan, Steven P. Balk, George G. Klee, Zhifu Sun, Donald J. Tindall, Liguo Wang, Chunxi Wang, Stephen A. Boorjian
Publikováno v:
Journal of Urology. 193:690-698
Spliced variant forms of androgen receptor were recently identified in castration resistant prostate cancer cell lines and clinical samples. We identified the cistrome and gene signature of androgen receptor splice variants in castration resistant pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7aaf5a1c4da0ecd714f7ecc837f1ab8
https://doi.org/10.1016/j.juro.2014.08.043
https://doi.org/10.1016/j.juro.2014.08.043
Autor:
Donald J. Tindall, Lucas P. Nacusi
Publikováno v:
Expert Review of Endocrinology & Metabolism. 4:417-422
The androgen receptor (AR) plays a critical role in prostate cancer (PCa) development and progression. Despite the success of androgen-deprivation therapy, remission occurs in almost all cases. This stage of the disease is called castration-recurrent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f2f7d9a5bd08676fc85b4c4966ca3ab
https://doi.org/10.1586/eem.09.34
https://doi.org/10.1586/eem.09.34
Autor:
Paul J. Leibson, Renee A. Schoon, Christopher J. Dick, Lucas P. Nacusi, Colin M. Segovis, Daniel D. Billadeau
Publikováno v:
The Journal of Immunology. 182:6933-6942
The NK cell-activating receptor NKG2D plays a critical role in the destruction of malignant cells, but many of the cell-signaling mechanisms governing NKG2D-mediated cellular cytotoxicity are unknown. We have identified an NKG2D-mediated signaling pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a784b3afcfc365f1cc513f9cf6b1a244
https://doi.org/10.4049/jimmunol.0803840
https://doi.org/10.4049/jimmunol.0803840
Autor:
Jeffrey C. Nolz, Daniel D. Billadeau, Yoji Shimizu, Rebecca Vasconcellos Botelho de Medeiros, Colin M. Segovis, Lucas P. Nacusi, Jason S. Mitchell
Publikováno v:
The Journal of Cell Biology
WAVE2 regulates T cell receptor (TCR)–stimulated actin cytoskeletal dynamics leading to both integrin clustering and affinity maturation. Although WAVE2 mediates integrin affinity maturation by recruiting vinculin and talin to the immunological syn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8089bb6cb2a4899d63b227e33646f39e
https://doi.org/10.1083/jcb.200801121
https://doi.org/10.1083/jcb.200801121
Autor:
Lucas P. Nacusi, Robert J. Sheaff
Publikováno v:
Pancreatology. 7:373-377
Disrupted cell cycle machinery is commonly thought to result in loss of proliferative control. Standard therapies target these rapidly dividing cells, yet they are ineffective against pancreatic cancer, suggesting that its development and/or progress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ec2ea5e9c1bdec3de9ddcd3d8c6a6b6
https://doi.org/10.1159/000107398
https://doi.org/10.1159/000107398
Publikováno v:
Biochemistry. 44:14553-14564
Multiple proteolytic pathways are involved in the degradation of the cyclin-dependent kinase inhibitor p21(Cip1/WAF1). Timed destruction of p21(Cip1/WAF1) plays a critical role in cell-cycle progression and cellular response to DNA damage. The SCF(Sk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::338764234b60100660dc5093690e099f
https://doi.org/10.1021/bi051071j
https://doi.org/10.1021/bi051071j
Autor:
Lucas P. Nacusi, Jose D. Debes
Publikováno v:
Pancreatology. 8:422-424
Nuclear receptors (NRs) are ligand-activated transcription factors that regulate gene expression. These receptors share a quite similar structure and mechanism of action. Upon ligand binding, NRs translocate from the cytoplasm to the nucleus and bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afde4d85499d94636b908094a3c5f06a
https://doi.org/10.1159/000151479
https://doi.org/10.1159/000151479
Autor:
Lucas P. Nacusi, Vicci L. Korman, Gretchen M. Unger, Diane K. Tobolt, Alvaro Mendoza, Alex J. Pretti
Publikováno v:
Cancer Research. 76:3746-3746
A high initial priming dose of the novel RNAi therapeutic GS-10 was investigated as a strategy to elevate important RISC complex proteins that have the potential to increase efficacy of subsequent RNAi treatment regimens in solid tumor cancers. GS-10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9753ca223bb58399ee9501d06bd5f90
https://doi.org/10.1158/1538-7445.am2016-3746
https://doi.org/10.1158/1538-7445.am2016-3746