Zobrazeno 1 - 10
of 250
pro vyhledávání: '"Lucas P Carvalho"'
Autor:
Laís Amorim Sacramento, Camila Farias Amorim, Claudia G Lombana, Daniel Beiting, Fernanda Novais, Lucas P Carvalho, Edgar M Carvalho, Phillip Scott
Publikováno v:
PLoS Pathogens, Vol 20, Iss 5, p e1012211 (2024)
Cytolytic CD8+ T cells mediate immunopathology in cutaneous leishmaniasis without controlling parasites. Here, we identify factors involved in CD8+ T cell migration to the lesion that could be targeted to ameliorate disease severity. CCR5 was the mos
Externí odkaz:
https://doaj.org/article/7117dd5863ba4854bd15cc637e19d37d
Autor:
Laís A Sacramento, Camila Farias Amorim, Taís M Campos, Maíra Saldanha, Sérgio Arruda, Lucas P Carvalho, Daniel P Beiting, Edgar M Carvalho, Fernanda O Novais, Phillip Scott
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 17, Iss 8, p e0011552 (2023)
Cutaneous leishmaniasis exhibits a spectrum of clinical presentations dependent upon the parasites' persistence and host immunopathologic responses. Although cytolytic CD8 T cells cannot control the parasites, they significantly contribute to patholo
Externí odkaz:
https://doaj.org/article/e0207c6016624022a4aa50a9a9f1c4c6
Autor:
Olivia A Pilling, João L Reis-Cunha, Cooper A Grace, Alexander S F Berry, Matthew W Mitchell, Jane A Yu, Clara R Malekshahi, Elise Krespan, Christina K Go, Cláudia Lombana, Yun S Song, Camila F Amorim, Alexsandro S Lago, Lucas P Carvalho, Edgar M Carvalho, Dustin Brisson, Phillip Scott, Daniel C Jeffares, Daniel P Beiting
Publikováno v:
PLoS Pathogens, Vol 19, Iss 3, p e1011230 (2023)
In Brazil, Leishmania braziliensis is the main causative agent of the neglected tropical disease, cutaneous leishmaniasis (CL). CL presents on a spectrum of disease severity with a high rate of treatment failure. Yet the parasite factors that contrib
Externí odkaz:
https://doaj.org/article/737717bbee8b47e590ec22cd8859a3a4
Autor:
Camila Farias Amorim, Fernanda O Novais, Ba T Nguyen, Mauricio T Nascimento, Jamile Lago, Alexsandro S Lago, Lucas P Carvalho, Daniel P Beiting, Phillip Scott
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 4, p e0009321 (2021)
Cutaneous leishmaniasis is a localized infection controlled by CD4+ T cells that produce IFN-γ within lesions. Phagocytic cells recruited to lesions, such as monocytes, are then exposed to IFN-γ which triggers their ability to kill the intracellula
Externí odkaz:
https://doaj.org/article/831669485c7f4f5a89de9e4a4de5a7b9
Autor:
Stephen M Christensen, Laura A L Dillon, Lucas P Carvalho, Sara Passos, Fernanda O Novais, V Keith Hughitt, Daniel P Beiting, Edgar M Carvalho, Phillip Scott, Najib M El-Sayed, David M Mosser
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 5, p e0005588 (2017)
[This corrects the article DOI: 10.1371/journal.pntd.0004992.].
Externí odkaz:
https://doaj.org/article/262fd8a16d9c4656b73e29de65da7b1f
Autor:
Fernanda O Novais, Augusto M Carvalho, Megan L Clark, Lucas P Carvalho, Daniel P Beiting, Igor E Brodsky, Edgar M Carvalho, Phillip Scott
Publikováno v:
PLoS Pathogens, Vol 13, Iss 2, p e1006196 (2017)
Deregulated CD8+ T cell cytotoxicity plays a central role in enhancing disease severity in several conditions. However, we have little understanding of the mechanisms by which immunopathology develops as a consequence of cytotoxicity. Using murine mo
Externí odkaz:
https://doaj.org/article/bf659d3cfad341d093c22b1295c01163
Autor:
Stephen M Christensen, Laura A L Dillon, Lucas P Carvalho, Sara Passos, Fernanda O Novais, V Keith Hughitt, Daniel P Beiting, Edgar M Carvalho, Phillip Scott, Najib M El-Sayed, David M Mosser
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 9, p e0004992 (2016)
Host and parasite gene expression in skin biopsies from Leishmania braziliensis-infected patients were simultaneously analyzed using high throughput RNA-sequencing. Biopsies were taken from 8 patients with early cutaneous leishmaniasis and 17 patient
Externí odkaz:
https://doaj.org/article/bb0256dc2d5a46f3b743829cc856a81b
Autor:
Geraldo Pedral-Sampaio, Jessé S Alves, Albert Schriefer, Andréa Magalhães, Roberto Meyer, Marshall J Glesby, Edgar M Carvalho, Lucas P Carvalho
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162793 (2016)
Diagnosis of cutaneous leishmaniasis (CL) relies on clinical presentation, parasite isolation, histopathologic evaluation and positive Montenegro skin test. However, the low amounts of parasites in the lesion of these individuals make parasite isolat
Externí odkaz:
https://doaj.org/article/e194b7284d43481291e96f0d73474790
Autor:
Taís M Campos, Sara T Passos, Fernanda O Novais, Daniel P Beiting, Rúbia S Costa, Adriano Queiroz, David Mosser, Phillip Scott, Edgar M Carvalho, Lucas P Carvalho
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 8, Iss 11, p e3282 (2014)
INTRODUCTION:Cutaneous leishmaniasis (CL) due to L.braziliensis infection is characterized by a strong inflammatory response with high levels of TNF and ulcer development. Less attention has been given to the role of mononuclear phagocytes to this pr
Externí odkaz:
https://doaj.org/article/e28e135f1ca6435c8f114cd50d44771f
Autor:
Claudia Gonzalez-Lombana, Ciara Gimblet, Olivia Bacellar, Walker W Oliveira, Sara Passos, Lucas P Carvalho, Michael Goldschmidt, Edgar M Carvalho, Phillip Scott
Publikováno v:
PLoS Pathogens, Vol 9, Iss 3, p e1003243 (2013)
Leishmaniasis, resulting from infection with the protozoan parasite Leishmania, consists of a wide spectrum of clinical manifestations, from healing cutaneous lesions to fatal visceral infections. A particularly severe form of cutaneous leishmaniasis
Externí odkaz:
https://doaj.org/article/195d1f3b39994636ad775fc0c92b6eac