Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Lucas M. Wiggenhauser"'
Autor:
Zayana M. Al-Dahmani, Xiaogang Li, Lucas M. Wiggenhauser, Hannes Ott, Paul D. Kruithof, Sergey Lunev, Fernando A. Batista, Yang Luo, Amalia M. Dolga, Nicholas M. Morton, Matthew R. Groves, Jens Kroll, Harry van Goor
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-7 (2022)
Abstract Thiosulfate sulfurtransferase (TST, EC 2.8.1.1), also known as Rhodanese, was initially discovered as a cyanide detoxification enzyme. However, it was recently also found to be a genetic predictor of resistance to obesity-related type 2 diab
Externí odkaz:
https://doaj.org/article/a6076927b73a465a973c4cbec05c6ca7
Autor:
Isabel T. N. Nguyen, Lucas M. Wiggenhauser, Marian Bulthuis, Jan-Luuk Hillebrands, Martin Feelisch, Marianne C. Verhaar, Harry van Goor, Jaap A. Joles
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Hypertension contributes to cardiac damage and remodeling. Despite the availability of renin-angiotensin system inhibitors and other antihypertensive therapies, some patients still develop heart failure. Novel therapeutic approaches are required that
Externí odkaz:
https://doaj.org/article/c3560343d2ce44d38fd4de1b39e336e4
Autor:
Lucas M. Wiggenhauser, Lena Metzger, Katrin Bennewitz, Silas Soleymani, Mike Boger, Christoph T. Tabler, Ingrid Hausser, Carsten Sticht, Paulus Wohlfart, Nadine Volk, Elena Heidenreich, Michael Buettner, Hans-Peter Hammes, Jens Kroll
Publikováno v:
Diabetes. 71:1073-1080
The pdx1−/− zebrafish mutant was recently established as a novel animal model of diabetic retinopathy. In this study, we investigate whether knockout of pdx1 also leads to diabetic kidney disease (DKD). pdx1−/− larvae exhibit several signs of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65a52f71bab0ea7249a6705afeeefd3c
https://doi.org/10.2337/db21-0645
https://doi.org/10.2337/db21-0645
Autor:
Jens Kroll, Hans-Peter Hammes, Michael Buettner, Elena Heidenreich, Nadine Volk, Paulus Wohlfart, Carsten Sticht, Ingrid Hausser, Christoph T. Tabler, Mike Boger, Silas Soleymani, Katrin Bennewitz, Lena Metzger, Lucas M. Wiggenhauser
The pdx1-/- zebrafish mutant was recently established as a novel animal model of diabetic retinopathy. Here, we investigate whether knockout of pdx1 also leads to diabetic kidney disease (DKD). pdx1-/- larvae exhibit several signs of early DKD such a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::520a6880375186248059adfaa47be408
https://doi.org/10.2337/figshare.19064054.v1
https://doi.org/10.2337/figshare.19064054.v1
Autor:
Marian Bulthuis, Guido Krenning, Harry van Goor, Leticia Quintanilla-Martinez, Jan-Luuk Hillebrands, Geert Harms, Rik Mencke, Hannes Olauson, Florian Lang, Anja T. Umbach, Lucas M. Wiggenhauser, Jakob Voelkl
Publikováno v:
The American Journal of Pathology, 189(12), 2503-2515. ELSEVIER SCIENCE INC
Hyalinosis is a vascular lesion affecting the renal vasculature and contributing to ageing-related renal function decline. We assessed whether arteriolar hyalinosis is caused by Klotho deficiency - a state known to induce both renal and vascular phen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe7948df4c6f9598a64d014fe47a26ca
https://doi.org/10.1016/j.ajpath.2019.08.006
https://doi.org/10.1016/j.ajpath.2019.08.006
Autor:
Lucas M. Wiggenhauser, Marian Bulthuis, Jaap A. Joles, Harry van Goor, Jan-Luuk Hillebrands, Isabel T.N. Nguyen, Martin Feelisch, Marianne C. Verhaar
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology, 12:650968, 1-11. Frontiers Media SA
Frontiers in Pharmacology
Frontiers in Pharmacology, 12:650968, 1-11. Frontiers Media SA
Frontiers in Pharmacology
Hypertension contributes to cardiac damage and remodeling. Despite the availability of renin-angiotensin system inhibitors and other antihypertensive therapies, some patients still develop heart failure. Novel therapeutic approaches are required that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c501b2d40d3f96b3ce47394b907cf4c
https://www.frontiersin.org/articles/10.3389/fphar.2021.650968/full
https://www.frontiersin.org/articles/10.3389/fphar.2021.650968/full
Autor:
Katrin Bennewitz, Lena Metzger, Gernot Poschet, Jan-Luuk Hillebrands, Lucas M. Wiggenhauser, Jens Kroll, Sandra J. Stoll, HP Hammes, Guido Krenning, Haozhe Qi
Publikováno v:
Diabetes, 69(5), 1020-1031. AMER DIABETES ASSOC
Progression from the initial vascular response upon hyperglycemia to a proliferative stage with neovacularizations is the hallmark of proliferative diabetic retinopathy. Here, we report on the novel diabetic pdx1−/− zebrafish mutant as a model fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22fcac97b8e2cffef470439bee291b30
https://research.rug.nl/en/publications/564b5a6c-211f-4b46-b0a5-3d1f34285961
https://research.rug.nl/en/publications/564b5a6c-211f-4b46-b0a5-3d1f34285961
Autor:
Lucas M, Wiggenhauser, Haozhe, Qi, Sandra J, Stoll, Lena, Metzger, Katrin, Bennewitz, Gernot, Poschet, Guido, Krenning, Jan-Luuk, Hillebrands, Hans-Peter, Hammes, Jens, Kroll
Publikováno v:
Diabetes. 69(5)
Progression from the initial vascular response upon hyperglycemia to a proliferative stage with neovacularizations is the hallmark of proliferative diabetic retinopathy. Here, we report on the novel diabetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7510fa5bb01ccd484f08317bb128138c
https://pubmed.ncbi.nlm.nih.gov/32139597
https://pubmed.ncbi.nlm.nih.gov/32139597
Autor:
Peter P. Nawroth, Gernot Poschet, Jakob Morgenstern, Thomas Fleming, Michael Büttner, Elisabeth Lodd, Christoph T. Tabler, David P. Wohlfart, Jens Kroll, Lucas M. Wiggenhauser
Publikováno v:
JCI insight 4:e126154 (2019)
The increased formation of methylglyoxal (MG) under hyperglycemia is associated with the development of microvascular complications in patients with diabetes mellitus; however, the effects of elevated MG levels in vivo are poorly understood. In zebra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ed613a97b4a2aec059197cd61f74a05
https://doi.org/10.1172/jci.insight.126154
https://doi.org/10.1172/jci.insight.126154
Autor:
Lucas M. Wiggenhauser, Jens Kroll
Publikováno v:
Current vascular pharmacology. 17(5)
Endothelial dysfunction is an initial pathophysiological mechanism of vascular damage and is further recognized as an independent predictor of negative prognosis in diabetes-induced micro- and macrovascular complications. Insight into the capability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6186db5371857b32bccd2388b73824ed
https://pubmed.ncbi.nlm.nih.gov/30378499
https://pubmed.ncbi.nlm.nih.gov/30378499