Výsledky vyhledávání - "Lucas M. Saposnik"

Akademický článek

A Gamma-adapted subunit vaccine induces broadly neutralizing antibodies against SARS-CoV-2 variants and protects mice from infection

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)

Abstract In the context of continuous emergence of SARS-CoV-2 variants of concern (VOCs), one strategy to prevent the severe outcomes of COVID-19 is developing safe and effective broad-spectrum vaccines. Here, we present preclinical studies of a RBD

Externí odkaz: https://doaj.org/article/98c078c53315430d8a5d5706aeabac1e

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Akademický článek

A Novel Bacterial Protease Inhibitor Adjuvant in RBD-Based COVID-19 Vaccine Formulations Containing Alum Increases Neutralizing Antibodies, Specific Germinal Center B Cells and Confers Protection Against SARS-CoV-2 Infection in Mice

Autor: Lorena M. Coria, Lucas M. Saposnik, Celeste Pueblas Castro, Eliana F. Castro, Laura A. Bruno, William B. Stone, Paula S. Pérez, Maria Laura Darriba, Lucia B. Chemes, Julieta Alcain, Ignacio Mazzitelli, Augusto Varese, Melina Salvatori, Albert J. Auguste, Diego E. Álvarez, Karina A. Pasquevich, Juliana Cassataro

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

In this work, we evaluated recombinant receptor binding domain (RBD)-based vaccine formulation prototypes with potential for further clinical development. We assessed different formulations containing RBD plus alum, AddaS03, AddaVax, or the combinati

Externí odkaz: https://doaj.org/article/7f7101efd88c4e0e81c0f30450a9b387

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A Gamma-adapted recombinant subunit vaccine induces broadly neutralizing antibodies against SARS-CoV-2 variants and protects mice from infection

The COVID-19 pandemic continues with the emergence of successive new variants of concern (VOC). One strategy to prevent breakthrough infections is developing safe and effective broad-spectrum vaccines. Here, we present preclinical studies of a RBD re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7c3fccdcb74be7be596e6317c65571b2
https://doi.org/10.1101/2023.01.03.522213

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Publikováno v: Frontiers in immunology. 13

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aaed66b6896c4cc08d0792e79fb941d
https://pubmed.ncbi.nlm.nih.gov/35296091

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A novel bacterial protease inhibitor adjuvant in RBD-based COVID-19 vaccine formulations increases neutralizing antibodies, specific germinal center B cells and confers protection against SARS-CoV-2 infection

Autor: Lorena M. Coria, Lucas M. Saposnik, Celeste Pueblas Castro, Eliana F. Castro, Laura A. Bruno, William B. Stone, Paula S. Pérez, M. Laura Darriba, Lucia B. Chemes, Julieta Alcain, Ignacio Mazzitelli, Augusto Varese, Melina Salvatori, Albert J. Auguste, Diego E Álvarez, Karina A. Pasquevich, Juliana Cassataro

In this work we evaluated recombinant receptor binding domain (RBD) based vaccine formulation prototypes with potential for further clinical development. We assessed different formulations containing RBD plus Alum, AddaS03, AddaVax or the combination

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac49c7746e38cac2b0f67b8430dde125
https://doi.org/10.1101/2021.12.07.471590

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