Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Lucas L. Falke"'
Autor:
Floris A. Valentijn, Sebastiaan N. Knoppert, Georgios Pissas, Raúl R. Rodrigues-Diez, Laura Marquez-Exposito, Roel Broekhuizen, Michal Mokry, Lennart A. Kester, Lucas L. Falke, Roel Goldschmeding, Marta Ruiz-Ortega, Theodoros Eleftheriadis, Tri Q. Nguyen
Publikováno v:
Antioxidants, Vol 10, Iss 12, p 2020 (2021)
AKI, due to the fact of altered oxygen supply after kidney transplantation, is characterized by renal ischemia–reperfusion injury (IRI). Recent data suggest that AKI to CKD progression may be driven by cellular senescence evolving from prolonged DN
Externí odkaz:
https://doaj.org/article/787739d7c94e4d27a7e660627d7f6df9
Autor:
Sebastian N. Knoppert, Floris A. Valentijn, Tri Q. Nguyen, Roel Goldschmeding, Lucas L. Falke
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Chronic kidney disease (CKD) is an increasing health burden (affecting approximately 13.4% of the population). Currently, no curative treatment options are available and treatment is focused on limiting the disease progression. The accumulation of se
Externí odkaz:
https://doaj.org/article/6a3462e32dab4a69a98abb5555bfbb0c
Autor:
Floris A. Valentijn, Sebastiaan N. Knoppert, Laura Marquez-Exposito, Raúl R. Rodrigues-Diez, Georgios Pissas, Jiaqi Tang, Lucia Tejedor-Santamaria, Roel Broekhuizen, Rohan Samarakoon, Theodoros Eleftheriadis, Roel Goldschmeding, Tri Q. Nguyen, Marta Ruiz-Ortega, Lucas L. Falke
Publikováno v:
Kidney international. 102(6)
Chronic allograft dysfunction with progressive fibrosis of unknown cause remains a major issue after kidney transplantation, characterized by ischemia-reperfusion injury (IRI). One hypothesis to account for this is that spontaneous progressive tubulo
Autor:
L.B. Steffensen, Ana M. Briones, Antonio Tejera-Muñoz, Marta Ruiz-Ortega, A. Ortiz, Esteban, Lucas L. Falke, Díez Rr, Egido J, Macarena Orejudo, Roel Goldschmeding, Bajo M, Mateos, Z. Mallat, Rodrigues-Diez R, Cannata P
Background and Purpose: Cellular Communication Network Factor 2 (CCN2) is a matricellular protein normally present in the vascular wall but overexpressed in several cardiovascular diseases. CCN2 has been proposed as a downstream mediator of profibrot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::916d321fac9d309a5a2901a0c2820e7f
https://doi.org/10.22541/au.162539389.90915406/v1
https://doi.org/10.22541/au.162539389.90915406/v1
Autor:
Rafael Kramann, Jürgen Floege, Turgay Saritas, Anne Babler, Sylvie Menzel, Jitske Jansen, Christoph Kuppe, Andrew S Kerker, Catherina A. Cuevas, Christian Bleilevens, Xiao-Tong Su, Katharina C Reimer, David H. Ellison, Lucas L. Falke, Peter Boor, Anne Rix, James A. McCormick, Lu Chen
Publikováno v:
Nephrology Dialysis Transplantation. 36
Background and Aims Chronic hypokalemia causes kidney fibrosis with cystic lesions and arterial hypertension. In contrast, potassium-rich diet lowers blood pressure. The acute effects of hypo- and hyperkalemia on heart and kidney are not well underst
Autor:
Antonio Tejera-Muñoz, Alberto Ortiz, Pablo Cannata-Ortiz, Macarena Orejudo, Roel Goldschmeding, L.B. Steffensen, Marta Ruiz-Ortega, Z. Mallat, Lucas L. Falke, Rafael Selgas, Jesús Egido, Vanesa Esteban, Raúl R. Rodrigues-Diez, Ana M. Briones, Sandra Rayego-Mateos, Raquel Rodrigues-Díez
Publikováno v:
Tejera-Munoz, A, Rodrigues-Diez, R R, Esteban, V, Steffensen, L B, Rodrigues-Diez, R, Orejudo, M, Rayego-Mateos, S, Falke, L L, Cannata-Ortiz, P, Ortiz, A, Egido, J, Mallat, Z, Briones, A M, Selgas, R, Goldschmeding, R & Ruiz-Ortega, M 2021, ' CTGF deficiency predisposes to aneurysm generation and rupture. Mineralocorticoid antagonist as potential therapeutic treatment ', Atherosclerosis, vol. 331, pp. E246-E247 . https://doi.org/10.1016/j.atherosclerosis.2021.06.754
Autor:
Roel Goldschmeding, Roel Broekhuizen, Nannan He, Susana M. Chuva de Sousa Lopes, Karen M. Lyons, Lucas L. Falke, Tri Q. Nguyen
Publikováno v:
Journal of cell communication and signaling, vol 14, iss 1
Pulmonary fibrosis is a severely disabling disease often leading to death. CCN2 (Cellular Communication Network factor 2, also known as CTGF) is a known mediator of fibrosis and clinical trials studying anti-CCN2 efficacy in pulmonary fibrosis are cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d88de82a0e244edbfaba8876f9aee9c
https://escholarship.org/uc/item/9fp7d128
https://escholarship.org/uc/item/9fp7d128
Autor:
Nannan He, Susana M. Chuva de Sousa Lopes, Roel Broekhuizen, Karen M. Lyons, Lucas L. Falke, Tri Q. Nguyen, Roel Goldschmeding
Publikováno v:
J Cell Commun Signal
Journal of cell communication and signaling, vol 13, iss 4
Journal of Cell Communication and Signaling, 13, 573-577. SPRINGER
Journal of cell communication and signaling, vol 13, iss 4
Journal of Cell Communication and Signaling, 13, 573-577. SPRINGER
Pulmonary fibrosis is a severely disabling disease often leading to death. CCN2 (Cellular Communication Network factor 2, also known as CTGF) is a known mediator of fibrosis and clinical trials studying anti-CCN2 efficacy in pulmonary fibrosis are cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e34f173fa5ca4ff82a07bade2866488f
https://doi.org/10.1007/s12079-020-00549-4
https://doi.org/10.1007/s12079-020-00549-4
Autor:
Jesús Egido, Roel Goldschmeding, Alberto Ortiz, Raquel Rodrigues-Díez, Sergio Mezzano, José Luis Morgado-Pascual, Lucas L. Falke, Marta Ruiz-Ortega, Sandra Rayego-Mateos, Raúl R. Rodrigues-Diez
Publikováno v:
The Journal of Pathology. 244:227-241
Connective tissue growth factor (CCN2/CTGF) is a matricellular protein that is overexpressed in progressive human renal diseases, mainly in fibrotic areas. In vitro studies have demonstrated that CCN2 regulates the production of extracellular matrix
Autor:
Roel Goldschmeding, Yasuhiko Ito, Andrew Leask, Hiroshi Kinashi, Jan Aten, Lucas L. Falke, Tri Q. Nguyen, Niels Bovenschen
Publikováno v:
Kidney international, 92(4), 850-863. Nature Publishing Group
Kidney International, 92(4), 850. Nature Publishing Group
Kidney International, 92(4), 850. Nature Publishing Group
Lymphangiogenesis is correlated with the degree of renal interstitial fibrosis. Pro-fibrotic transforming growth factor beta induces VEGF-C production, the main driver of lymphangiogenesis. Connective tissue growth factor (CTGF) is an important deter