Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Lucas K. Smith"'
Autor:
Karishma J.B. Pratt, Jeremy M. Shea, Laura Remesal-Gomez, Gregor Bieri, Lucas K. Smith, Julien Couthouis, Christopher P. Chen, Irena J. Roy, Geraldine Gontier, Saul A. Villeda
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 111926- (2023)
Externí odkaz:
https://doaj.org/article/4584548b6e5e4134bbd7a3d7e4518a9f
Autor:
Aleksandra Deczkowska, Orit Matcovitch-Natan, Afroditi Tsitsou-Kampeli, Sefi Ben-Hamo, Raz Dvir-Szternfeld, Amit Spinrad, Oded Singer, Eyal David, Deborah R. Winter, Lucas K. Smith, Alexander Kertser, Kuti Baruch, Neta Rosenzweig, Anna Terem, Marco Prinz, Saul Villeda, Ami Citri, Ido Amit, Michal Schwartz
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Microglia cells in the brain regulate immune responses, but in ageing can negatively affect brain function. Here the authors show that the chronic presence of type I interferon in aged mouse brain impedes cognitive ability by altering microglia trans
Externí odkaz:
https://doaj.org/article/e2dc3b78b5264d47bfe7a706887e8f6c
Autor:
Jerome Deval, Jin Hong, Guangyi Wang, Josh Taylor, Lucas K Smith, Amy Fung, Sarah K Stevens, Hong Liu, Zhinan Jin, Natalia Dyatkina, Marija Prhavc, Antitsa D Stoycheva, Vladimir Serebryany, Jyanwei Liu, David B Smith, Yuen Tam, Qingling Zhang, Martin L Moore, Rachel Fearns, Sushmita M Chanda, Lawrence M Blatt, Julian A Symons, Leo Beigelman
Publikováno v:
PLoS Pathogens, Vol 11, Iss 6, p e1004995 (2015)
Respiratory syncytial virus (RSV) causes severe lower respiratory tract infections, yet no vaccines or effective therapeutics are available. ALS-8176 is a first-in-class nucleoside analog prodrug effective in RSV-infected adult volunteers, and curren
Externí odkaz:
https://doaj.org/article/2d5adaa211d8415eabca3c2fc3171ff6
Autor:
Karishma J.B. Pratt, Jeremy M. Shea, Laura Remesal-Gomez, Gregor Bieri, Lucas K. Smith, Julien Couthouis, Christopher P. Chen, Irena J. Roy, Geraldine Gontier, Saul A. Villeda
Publikováno v:
Cell reports, vol 41, iss 6
DNA methylation has emerged as a critical modulator of neuronal plasticity and cognitive function. Notwithstanding, the role of enzymes that demethylate DNA remain to be fully explored. Here, we report that loss of ten-eleven translocation methylcyto
Autor:
Aurélie Hérault, Sietske T. Bakker, Paul V Dellorusso, Patrick Ventura, Lucas K. Smith, Carl A. Mitchell, Theodore T. Ho, Si Yi Zhang, Emmanuelle Passegué, Saul A. Villeda, Yoon-A Kang, Evgenia Verovskaya, Olivia M. Lansinger, Johanna Flach
Publikováno v:
The Journal of Experimental Medicine
Ho et al. demonstrate that old HSCs are extremely resistant to bloodborne systemic rejuvenation approaches and long-term exposure to a young BM niche microenvironment, maintaining a cell-intrinsic aged state. They also show that young HSCs are not af
Autor:
Lucas K. Smith, Wang Bowen, Jeremy M. Shea, Quoc-Hung Nguyen, John D. MacKenzie, Jaclyn Cadaoas, Russell G. Witt, Renan Sper, Tippi C. MacKenzie, Saul A. Villeda, Carlo Eikani, Gabrielle Boyle
Publikováno v:
British Journal of Surgery. 108
Introduction Mucopolysaccharidosis type 7 (MPS7) is a lysosomal storage disorder typically fatal in utero. Postnatal enzyme replacement therapy (ERT) to replace missing glucuronidase (GUS) does not penetrate the blood-brain barrier (BBB). We investig
Autor:
Peter Seizer, Karin Lin, Alana Horowitz, Evgenia Verovskaya, Gregor Bieri, Emmanuelle Passegué, Saul A. Villeda, Lucas K. Smith, Saskia N. I. von Ungern-Sternberg
Publikováno v:
Aging Cell
The aged systemic milieu promotes cellular and cognitive impairments in the hippocampus. Here, we report that aging of the hematopoietic system directly contributes to the pro‐aging effects of old blood on cognition. Using a heterochronic hematopoi
Autor:
Adam B. Schroer, Lucas K. Smith, Alana Horowitz, Saul A. Villeda, Joel H. Kramer, Xuelai Fan, Cesar Sanchez-Diaz, Gregor Bieri, Kaitlin B. Casaletto, Katherine E. Williams, Geraldine Gontier
Publikováno v:
Science (New York, N.Y.), vol 369, iss 6500
Plasma transfers exercise benefit in mice Exercise has a broad range of beneficial healthful effects. Horowitz et al. tested whether the beneficial effects of exercise on neurogenesis in the brain and improved cognition in aged mice could be transfer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e543384b787dec7790089a62ebbf588b
https://escholarship.org/uc/item/2zm1k030
https://escholarship.org/uc/item/2zm1k030
Autor:
Saul A. Villeda, John D. MacKenzie, Gabrielle Boyle, Jeremy M. Shea, Quoc-Hung Nguyen, Bowen Wang, Jaclyn Cadaoas, Russell G. Witt, Renan Sper, Lucas K. Smith, Tippi C. MacKenzie, Carlo Eikani
Publikováno v:
Science Translational Medicine. 12
Mucopolysaccharidosis type VII (MPS7) is a lysosomal storage disorder (LSD) resulting from mutations in the β-glucuronidase gene, leading to multiorgan dysfunction and fetal demise. While postnatal enzyme replacement therapy (ERT) and hematopoietic
Autor:
Charles W. White, Gregor Bieri, Sören Müller, Saul A. Villeda, Sun Y. Maybury-Lewis, Cedric E. Snethlage, Geraldine Gontier, Karin Lin, Lucas K. Smith
Publikováno v:
PLoS Biology
PLoS Biology, Vol 19, Iss 6, p e3001311 (2021)
PLoS Biology, Vol 19, Iss 6, p e3001311 (2021)
Proteins of the major histocompatibility complex class I (MHC I), predominantly known for antigen presentation in the immune system, have recently been shown to be necessary for developmental neural refinement and adult synaptic plasticity. However,