Systemic Loss and Gain of Chromatin Architecture throughout Zebrafish Development

Autor: Lucas J.T. Kaaij, Robin H. van der Weide, René F. Ketting, Elzo de Wit

Publikováno v: Cell Reports, Vol 24, Iss 1, Pp 1-10.e4 (2018)

Summary: The spatial organization of chromosomes is critical in establishing gene expression programs. We generated in situ Hi-C maps throughout zebrafish development to gain insight into higher-order chromatin organization and dynamics. Zebrafish ch

Externí odkaz: https://doaj.org/article/a6728150b3b24193bbd046936716d29a

Tdrd6a regulates the aggregation of Buc into functional subcellular compartments that drive germ cell specification

Autor: Lucas J.T. Kaaij, Falk Butter, António Miguel de Jesus Domingues, Kay Wiebrands, Alfred W Bronkhorst, Hsin Yi Huang, René F. Ketting, Dominic Grün, Stefan Redl, Elke F. Roovers, Alexander van Oudenaarden, Willi Salvenmoser, Chung-Ting Han

SummaryIn recent years, it has become clear that phase separation represents an important class of subcellular compartmentalization. However, relatively little is known about how the formation or disassembly of such compartments is regulated. In zebr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4218caef323b8d34577024108404e793
https://doi.org/10.1101/267971

Enhancers reside in a unique epigenetic environment during early zebrafish development

Autor: Geert Geeven, Andrew D. Smith, Christof Niehrs, Wouter de Laat, Michael U. Musheev, Ren� F. Ketting, Ant�nio M. de Jesus Domingues, Michal Mokry, Adrien S. J. Melquiond, Meng Zhou, Lucas J.T. Kaaij

Publikováno v: Genome Biology
Genome Biology, 17(1). BioMed Central
Genome Biology, 17. BioMed Central

Background Enhancers, not promoters, are the most dynamic in their DNA methylation status throughout development and differentiation. Generally speaking, enhancers that are primed to or actually drive gene expression are characterized by relatively l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6af891a6dd74eacdd8235d63643b9fa
http://europepmc.org/articles/PMC4934011

Tdrd6a Regulates the Aggregation of Buc into Functional Subcellular Compartments that Drive Germ Cell Specification

Autor: Chung-Ting Han, Dominic Grün, Roland Dosch, Alexander van Oudenaarden, Falk Butter, Lucas J.T. Kaaij, Stephan Riemer, Elke F. Roovers, Alfred W Bronkhorst, Willi Salvenmoser, René F. Ketting, António Miguel de Jesus Domingues, Stefan Redl, Kay Wiebrands, Hsin Yi Huang

Publikováno v: Developmental Cell, 46(3), 285-301.e9. Cell Press
Developmental Cell, 46(3), 285. Cell Press
Developmental Cell

Summary Phase separation represents an important form of subcellular compartmentalization. However, relatively little is known about how the formation or disassembly of such compartments is regulated. In zebrafish, the Balbiani body (Bb) and the germ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a34e69c6a4ec4de9de052a7985842f8
https://hdl.handle.net/1874/377225

Differential Impact of the HEN1 Homolog HENN-1 on 21U and 26G RNAs in the Germline of Caenorhabditis elegans

Autor: Eric A. Miska, Maartje J. Luteijn, René F. Ketting, Josien C. van Wolfswinkel, Leonie M. Kamminga, Marloes P. Bagijn, Eugene Berezikov, Alexandra Sapetschnig, Lucas J.T. Kaaij

Publikováno v: Plos Genetics, 8, 7
Plos Genetics, 8
PLoS Genetics
PLoS Genetics, Vol 8, Iss 7, p e1002702 (2012)
PLoS Genetics, 8(7). Public Library of Science

RNA interference (RNAi)-related pathways affect gene activity by sequence-specific recruitment of Ago proteins to mRNA target molecules. The sequence specificity of this process stems from small RNA (sRNA) co-factors bound by the Ago protein. Stabili

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3ce9e2c927f91d402926096d55a0c43
https://hdl.handle.net/2066/103296