Amyloid precursor protein is an autonomous growth cone adhesion molecule engaged in contact guidance.

Autor: Lucas J Sosa, Jared Bergman, Adriana Estrada-Bernal, Thomas J Glorioso, John M Kittelson, Karl H Pfenninger

Publikováno v: PLoS ONE, Vol 8, Iss 5, p e64521 (2013)

Amyloid precursor protein (APP), a transmembrane glycoprotein, is well known for its involvement in the pathogenesis of Alzheimer disease of the aging brain, but its normal function is unclear. APP is a prominent component of the adult as well as the

Externí odkaz: https://doaj.org/article/ed8a44d9f4c64fc78631a205bece65fa

IGF-1 receptor regulates dynamic changes in neuronal polarity during cerebral cortical migration

Autor: Alvaro F. Nieto Guil, Mariana Oksdath, Linnea A. Weiss, Diego J. Grassi, Lucas J. Sosa, Marta Nieto, Santiago Quiroga

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)

Abstract During cortical development, neurons undergo polarization, oriented migration and layer-type differentiation. The biological and biochemical mechanisms underlying these processes are not completely understood. In neurons in culture we showed

Externí odkaz: https://doaj.org/article/4883c92662b045dda79d1eb15277e16a

Kinesin-1-mediated axonal transport of CB1 receptors is required for cannabinoid-dependent axonal growth and guidance

Autor: Matías Alloatti, Diego Matias Gelman, María Gabriela Otero, Lucas J. Sosa, Tomás L. Falzone, Victorio Martin Pozo Devoto, María S. Rodríguez, Gonzalo Oubiña, Ivan Fernandez Bessone, Trinidad Saez, Lucas Eneas Cromberg, Mariano G. Buffone

Publikováno v: Development
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Endocannabinoids (eCB) modulate growth cone dynamics and axonal pathfinding through the stimulation of cannabinoid type-1 receptors (CB1R), the function of which depends on their delivery and precise presentation at the growth cone surface. However,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fbb4ed147a937c585391e1bab3ec25d
https://europepmc.org/articles/PMC7188441/

The physiological role of the amyloid precursor protein as an adhesion molecule in the developing nervous system

Autor: Alfredo Cáceres, Alfredo Lorenzo, Mariana Oksdath, Sebastian Dupraz, Santiago Quiroga, Lucas J. Sosa

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Journal of neurochemistry 143(1), 11-29 (2017). doi:10.1111/jnc.14122

The amyloid precursor protein (APP) is a type I transmembrane glycoprotein better known for its participation in the physiopathology of Alzheimer disease as the source of the beta amyloid fragment. However, the physiological functions of the full len

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::896ff31cec0fbc31ea05c790ee709a59
Wiley Online Library

Protein interacting with NIMA (never in mitosis A)-1 regulates axonal growth cone adhesion and spreading through myristoylated alanine-rich C kinase substrate isomerization

Autor: Mariana Oksdath, James S. Malter, Alvaro F. Nieto Guil, Lucas J. Sosa, Karl H. Pfenninger, Jie Hu, Santiago Quiroga, Florentyna Bustos Plonka

Axonal growth cone motility requires precise regulation of adhesion to navigate the complex environment of the nervous system and reach its target. Myristoylated alanine-rich C kinase substrate (MARCKS) protein is enriched in the developing brain and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65c15fc5587806a7104a56d78a0c5ae9
https://hdl.handle.net/11541.2/129602