Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Lucas J Bailey"'
Autor:
Zhening Zhang, Wenguang G Liang, Lucas J Bailey, Yong Zi Tan, Hui Wei, Andrew Wang, Mara Farcasanu, Virgil A Woods, Lauren A McCord, David Lee, Weifeng Shang, Rebecca Deprez-Poulain, Benoit Deprez, David R Liu, Akiko Koide, Shohei Koide, Anthony A Kossiakoff, Sheng Li, Bridget Carragher, Clinton S Potter, Wei-Jen Tang
Publikováno v:
eLife, Vol 7 (2018)
Insulin degrading enzyme (IDE) plays key roles in degrading peptides vital in type two diabetes, Alzheimer's, inflammation, and other human diseases. However, the process through which IDE recognizes peptides that tend to form amyloid fibrils remaine
Externí odkaz:
https://doaj.org/article/bdf640b40b944a06bfcc72ce62dd4071
Publikováno v:
Encyclopedia of Inorganic and Bioinorganic Chemistry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::717abf6ad6bff4f899bbc491fad6c951
https://doi.org/10.1002/9781119951438.eibc2700
https://doi.org/10.1002/9781119951438.eibc2700
Autor:
Jaeda L. Roberts, Sarah Zuerndorfer, Anya C. Dunaif, Jennifer T. Antane, Rachel P. Wallace, Stephan Kontos, Lucas J. Bailey, Roberto C. De Loera, Jeffrey A. Hubbell, Lorentz Kristen Marie, Rachel Weathered, Elyse A. Watkins, Andrew C Tremain, Mindy Nguyen
Publikováno v:
Science Immunology. 6
Although most current treatments for autoimmunity involve broad immunosuppression, recent efforts have aimed to suppress T cells in an antigen-specific manner to minimize risk of infection. One such effort is through targeting antigen to the apoptoti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36a4dfe6bd7eb82c6dd361de8777a30a
https://doi.org/10.1126/sciimmunol.abe1801
https://doi.org/10.1126/sciimmunol.abe1801
Publikováno v:
Nature. 544:191-195
Electrophilic aromatic substitution is one of the most important and recognizable classes of organic chemical transformation. Enzymes create the strong electrophiles that are needed for these highly energetic reactions by using O2, electrons, and met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4051bf0c4c674d5db5212b721ebc911f
https://doi.org/10.1038/nature21681
https://doi.org/10.1038/nature21681
Autor:
Lucas J. Bailey, Andrew Wang, Anthony A. Kossiakoff, Wei-Jen Tang, Tomasz Uchański, Mara Farcasanu, Xiaoyang Wu, Zhaochun Chen, Jiping Yue
Publikováno v:
Biochemistry. 58(27)
Anthrax, a lethal, weaponizable disease caused by Bacillus anthracis, acts through exotoxins that are primary mediators of systemic toxicity and also targets for neutralization by passive immunotherapy. The ease of engineering B. anthracis strains re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10ec1bb7374f8e4c76a9d50f5372b4f8
https://pubmed.ncbi.nlm.nih.gov/31243996
https://pubmed.ncbi.nlm.nih.gov/31243996
Publikováno v:
Protein Science. 25:1290-1298
Engineering monovalent Fab fragments into bivalent formats like IgGs or F(ab')2 can lead to aggregation presumably because of nonspecific off-target interactions that induce aggregation. In an effort to further understand the molecular determinants o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc79d570365b94d13787840c4b240aef
https://doi.org/10.1002/pro.2888
https://doi.org/10.1002/pro.2888
Autor:
Sheng Li, Lucas J. Bailey, Andrew Wang, Weifeng Shang, Bridget Carragher, Benoit Deprez, Zhening Zhang, Rebecca Deprez-Poulain, Lauren A McCord, Shohei Koide, Yong Zi Tan, Wei-Jen Tang, Mara Farcasanu, David R. Liu, Virgil A Woods, Akiko Koide, Hui Wei, Wenguang G. Liang, David Lee, Anthony A. Kossiakoff, Clinton S. Potter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f907bf83616d5ef73b52d5d92e3f9f42
https://doi.org/10.7554/elife.33572.086
https://doi.org/10.7554/elife.33572.086
Autor:
Clinton S. Potter, Shohei Koide, Bridget Carragher, David Lee, Virgil A Woods, Yong Zi Tan, Lauren A McCord, Wei-Jen Tang, Mara Farcasanu, David R. Liu, Andrew Wang, Weifeng Shang, Anthony A. Kossiakoff, Lucas J. Bailey, Akiko Koide, Hui Wei, Rebecca Deprez-Poulain, Wenguang G. Liang, Zhening Zhang, Sheng Li, Benoit Deprez
Publikováno v:
eLife
eLife, Vol 7 (2018)
eLife, Vol 7 (2018)
Insulin degrading enzyme (IDE) plays key roles in degrading peptides vital in type two diabetes, Alzheimer's, inflammation, and other human diseases. However, the process through which IDE recognizes peptides that tend to form amyloid fibrils remaine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38113570f93e555c279bd7319ef4a67d
Autor:
Pawel K. Dominik, Michael David Clark, Kimberly M. Sheehy, Huan Rui, Anthony A. Kossiakoff, Wenguang G. Liang, Mateusz Jaskolowski, Dawid Deneka, Yejoon Kim, Wei-Jen Tang, Lucas J. Bailey
Antibody Fab fragments have been exploited with significant success to facilitate the structure determination of challenging macromolecules as crystallization chaperones and as molecular fiducial marks for single particle cryo-electron microscopy app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d2dd3a4cefe1ff727a8feaf3deb4c88
https://europepmc.org/articles/PMC5800945/
https://europepmc.org/articles/PMC5800945/
Autor:
Steven A. Benner, Deepak Koirala, Lucas J. Bailey, Marcel Dupont, Stormy Ruiz, Joseph A. Piccirilli, Saurja DasGupta, Sandip A. Shelke
Publikováno v:
Nucleic Acids Research
Antibody fragments such as Fabs possess properties that can enhance protein and RNA crystallization and therefore can facilitate macromolecular structure determination. In particular, Fab BL3–6 binds to an AAACA RNA pentaloop closed by a GC pair wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fc8d54734ef46e9a567955045a2ba12
https://pubmed.ncbi.nlm.nih.gov/29309709
https://pubmed.ncbi.nlm.nih.gov/29309709