A Gain-of-Function Mutation in the α9 Nicotinic Acetylcholine Receptor Alters Medial Olivocochlear Efferent Short-Term Synaptic Plasticity

Autor: Mariano N. Di Guilmi, Ana Belén Elgoyhen, Carolina Wedemeyer, Paul A. Fuchs, Jimena A. Ballestero, Stéphane F. Maison, Marcelo J. Moglie, Julián Taranda, Eleonora Katz, Lucas G. Vattino, M. Charles Liberman

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Gain control of the auditory system operates at multiple levels. Cholinergic medial olivocochlear (MOC) fibers originate in the brainstem and make synaptic contacts at the base of the outer hair cells (OHCs), the final targets of several feedback loo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e3c3bef893ed97a63d16d0d446293f5
https://doi.org/10.1523/jneurosci.2528-17.2018

Acid-sensing ion channels 1a (ASIC1a) inhibit neuromuscular transmission in female mice

Autor: Francisco J. Urbano, Noelia G. Lino, Laura E. González, Natalia Claudia Colettis, Lucas G. Vattino, Carlota González-Inchauspe, John A. Wemmie, Amanda M. Wunsch, Osvaldo D. Uchitel

Publikováno v: American Journal of Physiology-Cell Physiology
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Acid-sensing ion channels (ASIC) open in response to extracellular acidosis. ASIC1a, a particular subtype of these channels, has been described to have a postsynaptic distribution in the brain, being involved not only in ischemia and epilepsy, but al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::600b016999c9043bd7eeac5641975052
http://europepmc.org/articles/PMC3919981

Amyotrophic lateral sclerosis-immunoglobulins selectively interact with neuromuscular junctions expressing P/Q-type calcium channels

Autor: Laura E, Gonzalez, Mónica L, Kotler, Lucas G, Vattino, Eugenia, Conti, Ricardo C, Reisin, Kirk J, Mulatz, Terrance P, Snutch, Osvaldo D, Uchitel

Publikováno v: Journal of neurochemistry. 119(4)

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by a gradual loss of motoneurons. The majority of ALS cases are associated with a sporadic form whose etiology is unknown. Several pieces of evidence favor autoimm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1122c5bb62f9b2cedb49fbac0302e85e
https://pubmed.ncbi.nlm.nih.gov/21883225