Nuclear and Cytoplasmic hTERT, Tumor-Infiltrating Lymphocytes, and Telomere Elongation Leukocytes Are Independent Factors in the Response to Neoadjuvant Treatment in HER2-Enriched Breast Cancer

Autor: Lucas Delmonico, José Bines, Cristina Moreira do Nascimento, Priscila Valverde Fernandes, Isabel de Souza Barbosa, Gabriel Brito Ribeiro, Bruno Henrique Rala de Paula, Rafaele Tavares Silvestre, Maria Helena Faria Ornellas, Gilda Alves, Claudia Lage

Publikováno v: Current Oncology, Vol 30, Iss 4, Pp 4094-4109 (2023)

HER2-enriched tumors are responsible for 20% of breast tumors and have high rates of immune infiltrates in the tumor stroma that respond favorably to neoadjuvant chemotherapy. In the context of tumors, telomeres control cell death and prevent tumor c

Externí odkaz: https://doaj.org/article/195f53b77b8641b1b1ab533c54b4fbd1

The contribution of the 20th century discoveries on the circulating DNA as biomarkers for cancer screening

Autor: GILDA ALVES, MARIANA CHANTRE, LUCAS DELMONICO

Publikováno v: Anais da Academia Brasileira de Ciências, Vol 92, Iss 4 (2020)

Abstract Circulating DNA can be released in the biological fluids by a physiological process and by different pathological conditions. The first reports detecting circulating DNA in human plasma date from the late 40s. Even when specific pathological

Externí odkaz: https://doaj.org/article/03dc3c0f45a24267816eedc7a6ebcc8d

Detecção dos Polimorfismos 213A→G e 13494G→A no Gene TP53 em Carcinoma Ductal in situ de Mama: Relato de Caso

Autor: Lucas Delmonico, Lívia Menezes, Marco Felipe Franco Rosa, Najla Marques de Oliveira Mattar, Eliane Barbosa Esteves, Vivian Rabello Areias, Carolina Maria de Azevedo, Gilda Alves

Publikováno v: Revista Brasileira de Cancerologia, Vol 59, Iss 3 (2013)

Introdução: A caracterização das alterações moleculares em lesões mamárias suspeitas para malignidade ainda não são bem definidas. Sabe-se que a detecção precoce do câncer de mama aumenta consideravelmente as chances de cura. Com isso, a

Externí odkaz: https://doaj.org/article/142b9b9437d64a95918e5be767f1c4b1

Overview of germline variants in the BRCA2 gene in cohort of Brazilian women with a high risk of hereditary breast cancer

Autor: Renata Mendes de Freitas, Gilda Alves, Maximiliano Ribeiro Guerra, Angélica Atala Lombelo Campos, Lucas Delmonico, Pedro Henrique de Oliveira Medeiros, Rafaela Russi Ervilha, Jane Rocha Duarte Cintra, Maria Teresa Bustamante Teixeira

Publikováno v: Mastology. 32

Introduction: Malignant breast cancer is the second most common type of cancer among women in the world, leaving behind nonmelanoma skin cancer. The aim of this study was to identify germline variants in the BRCA1 and BRCA2 genes in women diagnosed w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0d65dd6fc6ca8ace1ef78948b50ca1df
https://doi.org/10.29289/2594539420220003

Housekeeping genes involved in non-malignant breast phenotypes are widely expressed in multiple cancers and provide novel biomarkers of tumor classification

Autor: John C. Obenauer, Marcia V. Fournier, T.P. Stockfisch, Lucas Delmonico

Publikováno v: Brazilian Journal of Medical and Biological Research, Vol 54, Iss 7 (2021)
Brazilian Journal of Medical and Biological Research v.54 n.7 2021
Brazilian Journal of Medical and Biological Research
Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
Brazilian Journal of Medical and Biological Research, Volume: 54, Issue: 7, Article number: e10388, Published: 17 MAY 2021

Clinically relevant biomarkers are useful to determine cancer patients' prognosis and treatments. To discover new putative biomarkers, we performed in silico analysis of a 325-gene panel previously associated with breast epithelial cell biology and c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::005fb451b90f2e2e1fc796698abca9a5
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2021000700603&tlng=en