A Native CPP from Rattlesnake with Therapeutic and Theranostic Properties

Autor: Lucas Carvalho Porta, Joana D'Arc Campeiro, Mirian A. F. Hayashi

Publikováno v: Methods in Molecular Biology ISBN: 9781071617519

The cell-penetrating peptides (CPPs) are characterized by the ability of internalization into cells in vitro and in vivo, and the ability of these peptides can rely on a high content of positive charges, as it is the case of the native CPP crotamine.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cd7f67fc50e8d164829de3c448d8d081
https://doi.org/10.1007/978-1-0716-1752-6_6

In vivo effects of the association of the psychoactive phenotiazine thioridazine on antitumor activity and hind limb paralysis induced by the native polypeptide crotamine

Autor: Giovanna B. Papa, Lucas Carvalho Porta, Tiago Rodrigues, Rosely Oliveira Godinho, Mirian A. F. Hayashi, Joana D'Arc Campeiro, Eduardo B. Oliveira

Publikováno v: Toxicon : official journal of the International Society on Toxinology. 185

Crotamine is a cationic polypeptide composed by 42 amino acid residues with several pharmacological and biological properties, including the selective ability to enter and kill actively proliferating tumour cells, which led us to propose its use as a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d992cbf21550917899df080c6f50bcd
https://pubmed.ncbi.nlm.nih.gov/32621838

Crotamine Cell-Penetrating Nanocarriers: Cancer-Targeting and Potential Biotechnological and/or Medical Applications

Autor: Brian Szychowski, Lucas Carvalho Porta, Eduardo B. Oliveira, Irina Kerkis, Mirian A. F. Hayashi, Joana D'Arc Campeiro, Richard L. Karpel, Marie-Christine Daniel, Wendel A. Alves

Publikováno v: Methods in Molecular Biology ISBN: 9781071603185

Crotamine is a basic, 42-residue polypeptide from snake venom that has been shown to possess cell-penetrating properties. Here we describe the preparation, purification, biochemical and biophysical analysis of venom-derived, recombinant, chemically s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::233abd5de9ba1f424edf9f821ba9c014
https://doi.org/10.1007/978-1-0716-0319-2_5

Pharmacological characterization of crotamine effects on mice hind limb paralysis employing both ex vivo and in vivo assays: Insights into the involvement of voltage-gated ion channels in the crotamine action on skeletal muscles

Autor: Lucas Carvalho Porta, Mirian A. F. Hayashi, Thiago Duarte, Ywlliane da Silva Rodrigues Meurer, Regina H. Silva, Gisele Picolo, Nathalia B. Teixeira, Joana D'Arc Campeiro, Eduardo B. Oliveira, Rosely Oliveira Godinho, Alvaro C. Lima, Sunamita de Carvalho Lima

Publikováno v: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 12, Iss 8, p e0006700 (2018)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

The high medical importance of Crotalus snakes is unquestionable, as this genus is the second in frequency of ophidian accidents in many countries, including Brazil. With a relative less complex composition compared to other genera venoms, as those f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::094f290b891f1e2f259e5004671a138a
http://europepmc.org/articles/PMC6095621