Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Lucas Brusselle"'
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Akademický článek
Immunophenotype of a Rat Model of Duchenne's Disease and Demonstration of Improved Muscle Strength After Anti-CD45RC Antibody Treatment
Autor: Laure-Hélène Ouisse, Séverine Remy, Aude Lafoux, Thibaut Larcher, Laurent Tesson, Vanessa Chenouard, Carole Guillonneau, Lucas Brusselle, Nadège Vimond, Karl Rouger, Yann Péréon, Alexis Chenouard, Christèle Gras-Le Guen, Cécile Braudeau, Régis Josien, Corinne Huchet, Ignacio Anegon
Publikováno v: Frontiers in Immunology, Vol 10 (2019)
Corticosteroids (CS) are standard therapy for the treatment of Duchenne's muscular dystrophy (DMD). Even though they decrease inflammation, they have limited efficacy and are associated with significant side effects. There is therefore the need for n
Externí odkaz: https://doaj.org/article/a2895734cf364d49af8e3fda50f3a486
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2
Generation of Immunodeficient Rats With Rag1 and Il2rg Gene Deletions and Human Tissue Grafting Models
Autor: Jean-Paul Concordet, Carine Giovannangeli, Véronique Nerrière-Daguin, Frédérique Bellier-Waast, Laurent Tesson, Vanessa Chenouard, Delphine Garnier, Tuan H. Nguyen, Alexandre Fraichard, Séverine Ménoret, Emmanuel Merieau, Ignacio Anegon, Lucas Brusselle, Séverine Remy, Franck Duteille, Frédéric Delbos, Laure-Hélène Ouisse, Claire Usal
Publikováno v: Transplantation
Transplantation, 2018, 102 (8), pp.1271-1278. ⟨10.1097/TP.0000000000002251⟩
Transplantation, Lippincott, Williams & Wilkins, 2018, 102 (8), pp.1271-1278. ⟨10.1097/TP.0000000000002251⟩
Background Immunodeficient mice are invaluable tools to analyze the long-term effects of potentially immunogenic molecules in the absence of adaptive immune responses. Nevertheless, there are models and experimental situations that would beneficiate
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7db44e2e19605e63cbe336f3e0ffbf3d
https://doi.org/10.1097/tp.0000000000002251
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3
Immunological characterization of a rat model of Duchenne’s disease and demonstration of improved muscle strength after anti-CD45RC antibody treatment
Autor: Carole Guillonneau, Alexis Chenouard, Lucas Brusselle, Régis Josien, Laure-Hélène Ouisse, Chenouard, Laurent Tesson, Christèle Gras-Le Guen, Karl Rouger, Ignacio Anegon, Séverine Remy, Corinne Huchet, Yann Péréon, A. Lafoux, Nadège Vimond, Thibaut Larcher, Cécile Braudeau
Publikováno v: Frontiers in Immunology
Frontiers in Immunology, Frontiers, 2019, 10, ⟨10.1101/407023⟩
Duchenne muscular dystrophy (DMD) has as standard pharmacological therapy with corticoisteroids (CS) that decrease inflammation and immune responses present in patients and animal models. CS have however limited efficacy and important and numerous si
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f2aed7d06ebb316edd8701a131c72f4
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4
Advances in transgenic animal models and techniques
Autor: Laurent Tesson, Laure-Hélène Ouisse, Vanessa Chenouard, Claire Usal, Ignacio Anegon, Séverine Ménoret, Lucas Brusselle, Séverine Remy
Publikováno v: Transgenic Research
Transgenic Research, 2017, 26 (5), pp.703-708. ⟨10.1007/s11248-017-0038-x⟩
Transgenic Research, Springer Verlag, 2017, 26 (5), pp.703-708. ⟨10.1007/s11248-017-0038-x⟩
On May 11th and 12th 2017 was held in Nantes, France, the international meeting “Advances in transgenic animal models and techniques” ( http://www.trm.univ-nantes.fr/ ). This biennial meeting is the fifth one of its kind to be organized by the Tr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ddf5fbbd58ecb2deff1a81ddee57a38
https://www.hal.inserm.fr/inserm-02155396/file/s11248-017-0038-x.pdf
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5
Comparative Analysis of piggyBac, CRISPR/Cas9 and TALEN Mediated BAC Transgenesis in the Zygote for the Generation of Humanized SIRPA Rats
Autor: Laurent Tesson, Vanessa Chenouard, Lucas Brusselle, Laure-Hélène Ouisse, Claire Usal, Nicolas Poirier, Ignacio Anegon, Séverine Ménoret, Bernard Vanhove, Séverine Remy, Chris J. Jung, Pieter J. de Jong
Publikováno v: Scientific Reports
Scientific Reports, 2016, 6 (1), pp.31455. ⟨10.1038/srep31455⟩
Scientific Reports, Nature Publishing Group, 2016, 6 (1), pp.31455. ⟨10.1038/srep31455⟩
BAC transgenic mammalian systems offer an important platform for recapitulating human gene expression and disease modeling. While the larger body mass, and greater genetic and physiologic similarity to humans render rats well suited for reproducing h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd5ceccae7ffd2f3d36b3c53848bc341
https://doi.org/10.1038/srep31455
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6
A Rapid and Cost-Effective Method for Genotyping Genome-Edited Animals: A Heteroduplex Mobility Assay Using Microfluidic Capillary Electrophoresis
Autor: Laurent Tesson, Vanessa Chenouard, Lucas Brusselle, Laure-Hélène Ouisse, Séverine Remy, Claire Usal, Ignacio Anegon, Tuan Huy Nguyen, Jean-Marie Heslan, Séverine Ménoret
Publikováno v: International Journal of Genetics and Genomics
International Journal of Genetics and Genomics, Science Publishing Group, 2016, 43 (5), pp.341-348. ⟨10.1016/j.jgg.2016.04.005⟩
International Journal of Genetics and Genomics, 2016, 43 (5), pp.341-348. ⟨10.1016/j.jgg.2016.04.005⟩
International audience; The recent emergence and application of engineered endonucleases have led to the development of genome editing tools capable of rapidly implementing various targeted genome editions in a wide range of species. Moreover, these
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c20cdc2be72c659442801d4016d176a8
https://www.hal.inserm.fr/inserm-02150677
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7
Homology-directed repair in rodent zygotes using Cas9 and TALEN engineered proteins
Autor: Laurent Tesson, Jean-Paul Concordet, Alison Creneguy, Dominique Gauguier, Carine Giovannangeli, Yacine Cherifi, Alexandre Fraichard, Claire Usal, Reynald Thinard, Ignacio Anegon, Séverine Remy, Jean-Baptiste Boulé, Charlotte Boix, Anne De Cian, Tuan H. Nguyen, Lucas Brusselle, Sandra Fontanière, Séverine Ménoret
Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2015, 5, pp.14410. ⟨10.1038/srep14410⟩
Scientific Reports, 2015, 5, pp.14410. ⟨10.1038/srep14410⟩
Scientific Reports, Nature Publishing Group, 2015, 5, pp.14410. 〈10.1038/srep14410〉
The generation of genetically-modified organisms has been revolutionized by the development of new genome editing technologies based on the use of gene-specific nucleases, such as meganucleases, ZFNs, TALENs and CRISPRs-Cas9 systems. The most rapid a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d55f5d3103dfd1300e32189ab9fba715
https://hal.sorbonne-universite.fr/hal-01271745/file/srep14410.pdf
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8
Efficient Generation of Myostatin Knock-Out Sheep Using CRISPR/Cas9 Technology and Microinjection into Zygotes
Autor: Ignaco Anegón, F. Cuadro, A. P. Mulet, Laurent Tesson, N. Barrera, Martina Crispo, P.C. dos Santos-Neto, Alison Creneguy, Tuan H. Nguyen, Alejo Menchaca, Lucas Brusselle
Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2015, 10 (8), pp.e0136690. ⟨10.1371/journal.pone.0136690⟩
PLoS ONE, 2015, 10 (8), pp.e0136690. ⟨10.1371/journal.pone.0136690⟩
PLoS ONE, Vol 10, Iss 8, p e0136690 (2015)
International audience; While CRISPR/Cas9 technology has proven to be a valuable system to generate gene-targeted modified animals in several species, this tool has been scarcely reported in farm animals. Myostatin is encoded by MSTN gene involved in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::080ce1361befa0df59904f0c83aa3360
https://www.hal.inserm.fr/inserm-02148360/document
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