Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Lucas B. Sullivan"'
Autor:
Yingzhong Li, Nikola A. Ivica, Ting Dong, Dimitrios P. Papageorgiou, Yanpu He, Douglas R. Brown, Marianna Kleyman, Guangan Hu, Walter W. Chen, Lucas B. Sullivan, Amanda Del Rosario, Paula T. Hammond, Matthew G. Vander Heiden, Jianzhu Chen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Mitochondria maintain a balance between thermogenesis and ATP synthesis, but how this is coordinated is largely unknown. Here, the authors show that MFSD7C coordinates ATP synthesis and thermogenesis in response to heme by directly binding to electro
Externí odkaz:
https://doaj.org/article/f4b39f9789c94baca207b22daeaf19cc
Autor:
Andrew R. Mullen, Zeping Hu, Xiaolei Shi, Lei Jiang, Lindsey K. Boroughs, Zoltan Kovacs, Richard Boriack, Dinesh Rakheja, Lucas B. Sullivan, W. Marston Linehan, Navdeep S. Chandel, Ralph J. DeBerardinis
Publikováno v:
Cell Reports, Vol 7, Iss 5, Pp 1679-1690 (2014)
Mammalian cells generate citrate by decarboxylating pyruvate in the mitochondria to supply the tricarboxylic acid (TCA) cycle. In contrast, hypoxia and other impairments of mitochondrial function induce an alternative pathway that produces citrate by
Externí odkaz:
https://doaj.org/article/672968f1722f4fe88dc7b10759c626f1
Autor:
Kristian Davidsen, Lucas B Sullivan
Publikováno v:
eLife, Vol 12 (2024)
Current methods to quantify the fraction of aminoacylated tRNAs, also known as the tRNA charge, are limited by issues with either low throughput, precision, and/or accuracy. Here, we present an optimized charge transfer RNA sequencing (tRNA-Seq) meth
Externí odkaz:
https://doaj.org/article/f2010a5970994a5ca1cd0acc3cc33b3b
Publikováno v:
eLife, Vol 12 (2024)
Intracellular levels of the amino acid aspartate are responsive to changes in metabolism in mammalian cells and can correspondingly alter cell function, highlighting the need for robust tools to measure aspartate abundance. However, comprehensive und
Externí odkaz:
https://doaj.org/article/ffa31383e89e4b9381824921fba7f261
Autor:
Madeleine L Hart, Evan Quon, Anna-Lena BG Vigil, Ian A Engstrom, Oliver J Newsom, Kristian Davidsen, Pia Hoellerbauer, Samantha M Carlisle, Lucas B Sullivan
Publikováno v:
eLife, Vol 12 (2023)
The oxidative tricarboxylic acid (TCA) cycle is a central mitochondrial pathway integrating catabolic conversions of NAD +to NADH and anabolic production of aspartate, a key amino acid for cell proliferation. Several TCA cycle components are implicat
Externí odkaz:
https://doaj.org/article/b4116c4d572544a4a487e9aeabc9e789
Autor:
Hiep Tai Nguyen, Weiliang Tang, Andrew L. H. Webster, Jeffrey R. Whiteaker, Christopher M. Chandler, Ricardo Errazquin, Khashayar Roohollahi, Madeline Fritzke, Elizabeth E. Hoskins, Erica Jonlin, Leslie Wakefield, Lucas B. Sullivan, Eleanor Y. Chen, Josephine Dorsman, Ruud Brakenhoff, Amanda G. Paulovich, Markus Grompe, Ramon Garcia‐Escudero, Susanne I. Wells, Agata Smogorzewska, Raymond J. Monnat
Publikováno v:
International Journal of Cancer, 153(1), 183-196. Wiley-Liss Inc.
Nguyen, H T, Tang, W, Webster, A L H, Whiteaker, J R, Chandler, C M, Errazquin, R, Roohollahi, K, Fritzke, M, Hoskins, E E, Jonlin, E, Wakefield, L, Sullivan, L B, Chen, E Y, Dorsman, J, Brakenhoff, R, Paulovich, A G, Grompe, M, Garcia-Escudero, R, Wells, S I, Smogorzewska, A & Monnat, R J 2023, ' Fanconi anemia-isogenic head and neck cancer cell line pairs : A basic and translational science resource ', International Journal of Cancer, vol. 153, no. 1, pp. 183-196 . https://doi.org/10.1002/ijc.34506
Nguyen, H T, Tang, W, Webster, A L H, Whiteaker, J R, Chandler, C M, Errazquin, R, Roohollahi, K, Fritzke, M, Hoskins, E E, Jonlin, E, Wakefield, L, Sullivan, L B, Chen, E Y, Dorsman, J, Brakenhoff, R, Paulovich, A G, Grompe, M, Garcia-Escudero, R, Wells, S I, Smogorzewska, A & Monnat, R J 2023, ' Fanconi anemia-isogenic head and neck cancer cell line pairs : A basic and translational science resource ', International Journal of Cancer, vol. 153, no. 1, pp. 183-196 . https://doi.org/10.1002/ijc.34506
Fanconi anemia (FA) is a heritable malformation, bone marrow failure and cancer predisposition syndrome that confers an exceptionally high risk of developing carcinomas arising in squamous mucosal epithelia lining the mouth, proximal esophagus, vulva
Autor:
Sarah B. Crist, Travis Nemkov, Ruth F. Dumpit, Jinxiang Dai, Stephen J. Tapscott, Lawrence D. True, Alexander Swarbrick, Lucas B. Sullivan, Peter S. Nelson, Kirk C. Hansen, Cyrus M. Ghajar
Publikováno v:
Nature Cell Biology. 24:538-553
Autor:
Madeleine L Hart, Evan Quon, Anna-Lena BG Vigil, Ian A Engstrom, Oliver J Newsom, Kristian Davidsen, Pia Hoellerbauer, Samantha M Carlisle, Lucas B Sullivan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b7513eed835b0d4a9677bf7edc82081
https://doi.org/10.7554/elife.78654.sa2
https://doi.org/10.7554/elife.78654.sa2
Autor:
Sinéad Kinsella, Cindy A. Evandy, Kirsten Cooper, Antonella Cardinale, Lorenzo Iovino, Paul deRoos, Kayla S. Hopwo, Colton W. Smith, David Granadier, Lucas B. Sullivan, Enrico Velardi, Jarrod A. Dudakov
Endogenous thymic regeneration is a crucial process that allows for the renewal of immune competence following stress, infection or cytoreductive conditioning. Fully understanding the molecular mechanisms driving regeneration will uncover therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18efc9a131627f508f25e89f68542965
https://doi.org/10.1101/2023.01.19.524800
https://doi.org/10.1101/2023.01.19.524800
Autor:
Carla Jaeger, Yun Lo, Elena Fulton, Olivia Waltner, Tamer B. Shabaneh, Colin E. Correnti, Oliver Newsom, Ian A. Engstrom, Sami B. Kanaan, Shruti S. Bhise, Jobelle M.C. Peralta, Raymond Ruff, Jason P. Price, Sylvia M. Stull, Andrew R. Stevens, Valentin Voillet, Vishaka Muhunthan, Fionnuala Morrish, James M. Olson, Raphaël Gottardo, Jay Sarthy, Steven Henikoff, Lucas B. Sullivan, Scott N. Furlan, Stanley R. Riddell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72ef94d2d007888398e97ff450e7c929
https://doi.org/10.2139/ssrn.4402129
https://doi.org/10.2139/ssrn.4402129