Leishmania Ribosomal Protein (RP) paralogous genes compensate each other's expression maintaining protein native levels.

Autor: Francisca S Borges, José C Quilles, Lucas B Lorenzon, Caroline R Espada, Felipe Freitas-Castro, Tânia P A Defina, Fabíola B Holetz, Angela K Cruz

Publikováno v: PLoS ONE, Vol 19, Iss 5, p e0292152 (2024)

In the protozoan parasite Leishmania, most genes encoding for ribosomal proteins (RPs) are present as two or more copies in the genome. However, their untranslated regions (UTRs) are predominantly divergent and might be associated with a distinct reg

Externí odkaz: https://doaj.org/article/cdd62abe89a644a783d583c35fe89490

Effective Genome Editing in Leishmania (Viannia) braziliensis Stably Expressing Cas9 and T7 RNA Polymerase

Autor: Caroline R. Espada, José Carlos Quilles, Andreia Albuquerque-Wendt, Mario C. Cruz, Tom Beneke, Lucas B. Lorenzon, Eva Gluenz, Angela K. Cruz, Silvia R. B. Uliana

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)

Until 2015, loss-of-function studies to elucidate protein function in Leishmania relied on gene disruption through homologous recombination. Then, the CRISPR/Cas9 revolution reached these protozoan parasites allowing efficient genome editing with one

Externí odkaz: https://doaj.org/article/1ed30db54fd34d5c921c74416a427932

Publisher Correction: Leishmania RNA virus exacerbates Leishmaniasis by subverting innate immunity via TLR3-mediated NLRP3 inflammasome inhibition

Autor: Renan V. H. de Carvalho, Djalma S. Lima-Junior, Marcus Vinícius G. da Silva, Marisa Dilucca, Tamara S. Rodrigues, Catarina V. Horta, Alexandre L. N. Silva, Patrick F. da Silva, Fabiani G. Frantz, Lucas B. Lorenzon, Marcos Michel Souza, Fausto Almeida, Lilian M. Cantanhêde, Ricardo de Godoi M. Ferreira, Angela K. Cruz, Dario S. Zamboni

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Externí odkaz: https://doaj.org/article/71955a4e0c37464bb3048cc67df7a7a0

Protein methyltransferase 7 deficiency in Leishmania major increases neutrophil associated pathology in murine model

Autor: Rafael Ricci-Azevedo, Mariana M. Chaves, Dario S. Zamboni, Rubens Daniel Miserani Magalhães, Tiago R. Ferreira, Pegine B. Walrad, Renan V. H. de Carvalho, David L. Sacks, Slavica Vaselek, Angela K. Cruz, Juliana Alcoforado Diniz, Lucas B. Lorenzon, Petr Volf

Publikováno v: PLoS Neglected Tropical Diseases, Vol 15, Iss 3, p e0009230 (2021)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
PLoS Neglected Tropical Diseases
PLOS Neglected Tropical Diseases

Leishmania major is the main causative agent of cutaneous leishmaniasis in the Old World. In Leishmania parasites, the lack of transcriptional control is mostly compensated by post-transcriptional mechanisms. Methylation of arginine is a conserved po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a19cb51e29b2c50b89620c84d3976760
https://doaj.org/article/fc6c456a480446dd8f8cc9b8f8b6c3d8

Leishmania RNA virus exacerbates Leishmaniasis by subverting innate immunity via TLR3-mediated NLRP3 inflammasome inhibition

Autor: Marisa Dilucca, Tamara S Rodrigues, Renan V. H. de Carvalho, Djalma S. Lima-Junior, Angela K. Cruz, Dario S. Zamboni, Ricardo de Godoi Mattos Ferreira, Fausto Almeida, Alexandre L. N. Silva, Fabiani Gai Frantz, Catarina V. Horta, Marcos Michel de Souza, Patrick F. da Silva, Lucas B. Lorenzon, Lilian Motta Cantanhêde, Marcus Vinicius Gomes da Silva

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Nature Communications
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Leishmania RNA virus (LRV) is an important virulence factor associated with the development of mucocutaneous Leishmaniasis, a severe form of the disease. LRV-mediated disease exacerbation relies on TLR3 activation, but downstream mechanisms remain la

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::766b0d7ae6f6b589a2908e669ce093f3
https://doi.org/10.1038/s41467-019-13356-2