Výsledky vyhledávání - "Lucas B Lorenzon"

Akademický článek

Leishmania Ribosomal Protein (RP) paralogous genes compensate each other's expression maintaining protein native levels.

Autor: Francisca S Borges, José C Quilles, Lucas B Lorenzon, Caroline R Espada, Felipe Freitas-Castro, Tânia P A Defina, Fabíola B Holetz, Angela K Cruz

Publikováno v: PLoS ONE, Vol 19, Iss 5, p e0292152 (2024)

In the protozoan parasite Leishmania, most genes encoding for ribosomal proteins (RPs) are present as two or more copies in the genome. However, their untranslated regions (UTRs) are predominantly divergent and might be associated with a distinct reg

Externí odkaz: https://doaj.org/article/cdd62abe89a644a783d583c35fe89490

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Akademický článek

Effective Genome Editing in Leishmania (Viannia) braziliensis Stably Expressing Cas9 and T7 RNA Polymerase

Autor: Caroline R. Espada, José Carlos Quilles, Andreia Albuquerque-Wendt, Mario C. Cruz, Tom Beneke, Lucas B. Lorenzon, Eva Gluenz, Angela K. Cruz, Silvia R. B. Uliana

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)

Until 2015, loss-of-function studies to elucidate protein function in Leishmania relied on gene disruption through homologous recombination. Then, the CRISPR/Cas9 revolution reached these protozoan parasites allowing efficient genome editing with one

Externí odkaz: https://doaj.org/article/1ed30db54fd34d5c921c74416a427932

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Akademický článek

Leishmania RNA virus exacerbates Leishmaniasis by subverting innate immunity via TLR3-mediated NLRP3 inflammasome inhibition

Autor: Renan V. H. de Carvalho, Djalma S. Lima-Junior, Marcus Vinícius G. da Silva, Marisa Dilucca, Tamara S. Rodrigues, Catarina V. Horta, Alexandre L. N. Silva, Patrick F. da Silva, Fabiani G. Frantz, Lucas B. Lorenzon, Marcos Michel Souza, Fausto Almeida, Lilian M. Cantanhêde, Ricardo de Godoi M. Ferreira, Angela K. Cruz, Dario S. Zamboni

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)

NLRP3 activation by Leishmania parasites is critical to the outcome of the disease. Here the authors show that LRV, a virus infecting Leishmania strains associated with more severe human disease, enables the parasite to suppress the inflammasome by a

Externí odkaz: https://doaj.org/article/41009faa319b4c89b800738bd6213733

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Akademický článek

Protein methyltransferase 7 deficiency in Leishmania major increases neutrophil associated pathology in murine model.

Autor: Juliana Alcoforado Diniz, Mariana M Chaves, Slavica Vaselek, Rubens D Miserani Magalhães, Rafael Ricci-Azevedo, Renan V H de Carvalho, Lucas B Lorenzon, Tiago R Ferreira, Dario Zamboni, Pegine B Walrad, Petr Volf, David L Sacks, Angela K Cruz

Publikováno v: PLoS Neglected Tropical Diseases, Vol 15, Iss 3, p e0009230 (2021)

Leishmania major is the main causative agent of cutaneous leishmaniasis in the Old World. In Leishmania parasites, the lack of transcriptional control is mostly compensated by post-transcriptional mechanisms. Methylation of arginine is a conserved po

Externí odkaz: https://doaj.org/article/fc6c456a480446dd8f8cc9b8f8b6c3d8

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Akademický článek

Publisher Correction: Leishmania RNA virus exacerbates Leishmaniasis by subverting innate immunity via TLR3-mediated NLRP3 inflammasome inhibition

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Externí odkaz: https://doaj.org/article/71955a4e0c37464bb3048cc67df7a7a0

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Functional study ofLeishmania braziliensisprotein arginine methyltransferases (PRMTs) reveals that PRMT1 and PRMT5 are required for macrophage infection

Autor: J. Alcoforado Diniz, Tiago R. Ferreira, Lucas B. Lorenzon, Rubens Daniel Miserani Magalhães, Flávio Protaso Veras, G. D. Campagnaro, Luiz Gustavo de Almeida, José C. Quilles, Angela K. Cruz

In trypanosomatids, regulation of gene expression occurs mainly at the posttranscriptional level, and RNA-binding proteins (RBPs) are key players in determining the fates of transcripts. RBPs are major targets of protein arginine methyltransferases (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8d9b314863a79ba7819f770efc7444c2
https://doi.org/10.1101/2021.09.22.461376

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Protein methyltransferase 7 deficiency in Leishmania major increases neutrophil associated pathology in murine model

Autor: Rafael Ricci-Azevedo, Mariana M. Chaves, Dario S. Zamboni, Rubens Daniel Miserani Magalhães, Tiago R. Ferreira, Pegine B. Walrad, Renan V. H. de Carvalho, David L. Sacks, Slavica Vaselek, Angela K. Cruz, Juliana Alcoforado Diniz, Lucas B. Lorenzon, Petr Volf

Publikováno v: PLoS Neglected Tropical Diseases, Vol 15, Iss 3, p e0009230 (2021)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
PLoS Neglected Tropical Diseases
PLOS Neglected Tropical Diseases

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a19cb51e29b2c50b89620c84d3976760
https://doaj.org/article/fc6c456a480446dd8f8cc9b8f8b6c3d8

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