Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Lucas B Carey"'
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 11, p e1009582 (2021)
Isogenic cells cultured together show heterogeneity in their proliferation rate. To determine the differences between fast and slow-proliferating cells, we developed a method to sort cells by proliferation rate, and performed RNA-seq on slow and fast
Externí odkaz:
https://doaj.org/article/10db488fa4ed49b68a9a22351a3c0d9c
Autor:
Victoria O Pokusaeva, Dinara R Usmanova, Ekaterina V Putintseva, Lorena Espinar, Karen S Sarkisyan, Alexander S Mishin, Natalya S Bogatyreva, Dmitry N Ivankov, Arseniy V Akopyan, Sergey Ya Avvakumov, Inna S Povolotskaya, Guillaume J Filion, Lucas B Carey, Fyodor A Kondrashov
Publikováno v:
PLoS Genetics, Vol 15, Iss 4, p e1008079 (2019)
Characterizing the fitness landscape, a representation of fitness for a large set of genotypes, is key to understanding how genetic information is interpreted to create functional organisms. Here we determined the evolutionarily-relevant segment of t
Externí odkaz:
https://doaj.org/article/e66bf1d0a4ec429799bdc20106b09434
Publikováno v:
eLife, Vol 8 (2019)
Mutations frequently have outcomes that differ across individuals, even when these individuals are genetically identical and share a common environment. Moreover, individual microbial and mammalian cells can vary substantially in their proliferation
Externí odkaz:
https://doaj.org/article/56dac88272c643a6a5d0dd0382ac794a
Autor:
Lucas B Carey
Publikováno v:
eLife, Vol 4 (2015)
Errors during transcription may play an important role in determining cellular phenotypes: the RNA polymerase error rate is >4 orders of magnitude higher than that of DNA polymerase and errors are amplified >1000-fold due to translation. However, cur
Externí odkaz:
https://doaj.org/article/617a45dfe1764c5d9682830f844ef536
Publikováno v:
PLoS Biology, Vol 11, Iss 4, p e1001528 (2013)
The ability of cells to accurately control gene expression levels in response to extracellular cues is limited by the inherently stochastic nature of transcriptional regulation. A change in transcription factor (TF) activity results in changes in the
Externí odkaz:
https://doaj.org/article/9c004eaef6e144519c32f4d0474494c3
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54403 (2013)
Phenotypic traits may be gained and lost together because of pleiotropy, the involvement of common genes and networks, or because of simultaneous selection for multiple traits across environments (multiple-trait coevolution). However, the extent to w
Externí odkaz:
https://doaj.org/article/c7c19009852a41f4b82d9b1c27fdb414
Publikováno v:
PLoS Biology, Vol 7, Iss 9, p e1000189 (2009)
In yeast, the G1 cyclin Cln3 promotes cell cycle entry by activating the transcription factor SBF. In mammals, there is a parallel system for cell cycle entry in which cyclin dependent kinase (CDK) activates transcription factor E2F/Dp. Here we show
Externí odkaz:
https://doaj.org/article/672c3d4978ac449fa0bea45244344a32
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 17, Iss 11, p e1009582 (2021)
PLoS Computational Biology, Vol 17, Iss 11, p e1009582 (2021)
Isogenic cells cultured together show heterogeneity in their proliferation rate. To determine the differences between fast and slow-proliferating cells, we developed a method to sort cells by proliferation rate, and performed RNA-seq on slow and fast
Publikováno v:
Recercat. Dipósit de la Recerca de Catalunya
instname
Genome Res
instname
Genome Res
DNA replication perturbs the dosage balance among genes; at mid-S phase, early-replicating genes have doubled their copies while late-replicating ones have not. Dosage imbalance among genes, especially within members of a protein complex, is toxic to
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Recercat. Dipósit de la Recerca de Catalunya
instname
Nature Communications
Recercat. Dipósit de la Recerca de Catalunya
instname
Nature Communications
The effects of cell-to-cell variation (noise) in gene expression have proven difficult to quantify because of the mechanistic coupling of noise to mean expression. To independently quantify the effects of changes in mean expression and noise we deter