Zobrazeno 1 - 10 of 55 pro vyhledávání: '"Lucas B, Sullivan"'
1
Akademický článek
A robust method for measuring aminoacylation through tRNA-Seq
Autor: Kristian Davidsen, Lucas B Sullivan
Publikováno v: eLife, Vol 12 (2024)
Current methods to quantify the fraction of aminoacylated tRNAs, also known as the tRNA charge, are limited by issues with either low throughput, precision, and/or accuracy. Here, we present an optimized charge transfer RNA sequencing (tRNA-Seq) meth
Externí odkaz: https://doaj.org/article/f2010a5970994a5ca1cd0acc3cc33b3b
Zobrazit plný text záznamu
2
Akademický článek
An engineered biosensor enables dynamic aspartate measurements in living cells
Autor: Kristian Davidsen, Jonathan S Marvin, Abhi Aggarwal, Timothy A Brown, Lucas B Sullivan
Publikováno v: eLife, Vol 12 (2024)
Intracellular levels of the amino acid aspartate are responsive to changes in metabolism in mammalian cells and can correspondingly alter cell function, highlighting the need for robust tools to measure aspartate abundance. However, comprehensive und
Externí odkaz: https://doaj.org/article/ffa31383e89e4b9381824921fba7f261
Zobrazit plný text záznamu
3
Akademický článek
Mitochondrial redox adaptations enable alternative aspartate synthesis in SDH-deficient cells
Autor: Madeleine L Hart, Evan Quon, Anna-Lena BG Vigil, Ian A Engstrom, Oliver J Newsom, Kristian Davidsen, Pia Hoellerbauer, Samantha M Carlisle, Lucas B Sullivan
Publikováno v: eLife, Vol 12 (2023)
The oxidative tricarboxylic acid (TCA) cycle is a central mitochondrial pathway integrating catabolic conversions of NAD +to NADH and anabolic production of aspartate, a key amino acid for cell proliferation. Several TCA cycle components are implicat
Externí odkaz: https://doaj.org/article/b4116c4d572544a4a487e9aeabc9e789
Zobrazit plný text záznamu
4
Akademický článek
MFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme
Autor: Yingzhong Li, Nikola A. Ivica, Ting Dong, Dimitrios P. Papageorgiou, Yanpu He, Douglas R. Brown, Marianna Kleyman, Guangan Hu, Walter W. Chen, Lucas B. Sullivan, Amanda Del Rosario, Paula T. Hammond, Matthew G. Vander Heiden, Jianzhu Chen
Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Mitochondria maintain a balance between thermogenesis and ATP synthesis, but how this is coordinated is largely unknown. Here, the authors show that MFSD7C coordinates ATP synthesis and thermogenesis in response to heme by directly binding to electro
Externí odkaz: https://doaj.org/article/f4b39f9789c94baca207b22daeaf19cc
Zobrazit plný text záznamu
5
Fanconi anemia-isogenic head and neck cancer cell line pairs
Autor: Hiep Tai Nguyen, Weiliang Tang, Andrew L. H. Webster, Jeffrey R. Whiteaker, Christopher M. Chandler, Ricardo Errazquin, Khashayar Roohollahi, Madeline Fritzke, Elizabeth E. Hoskins, Erica Jonlin, Leslie Wakefield, Lucas B. Sullivan, Eleanor Y. Chen, Josephine Dorsman, Ruud Brakenhoff, Amanda G. Paulovich, Markus Grompe, Ramon Garcia‐Escudero, Susanne I. Wells, Agata Smogorzewska, Raymond J. Monnat
Publikováno v: International Journal of Cancer, 153(1), 183-196. Wiley-Liss Inc.
Nguyen, H T, Tang, W, Webster, A L H, Whiteaker, J R, Chandler, C M, Errazquin, R, Roohollahi, K, Fritzke, M, Hoskins, E E, Jonlin, E, Wakefield, L, Sullivan, L B, Chen, E Y, Dorsman, J, Brakenhoff, R, Paulovich, A G, Grompe, M, Garcia-Escudero, R, Wells, S I, Smogorzewska, A & Monnat, R J 2023, ' Fanconi anemia-isogenic head and neck cancer cell line pairs : A basic and translational science resource ', International Journal of Cancer, vol. 153, no. 1, pp. 183-196 . https://doi.org/10.1002/ijc.34506
Fanconi anemia (FA) is a heritable malformation, bone marrow failure and cancer predisposition syndrome that confers an exceptionally high risk of developing carcinomas arising in squamous mucosal epithelia lining the mouth, proximal esophagus, vulva
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e015dddfce92f17afb210d60a0683723
https://doi.org/10.1002/ijc.34506
Zobrazit plný text záznamu
8
Damage-induced pyroptosis drives endogenous thymic regeneration via induction of Foxn1 by purinergic receptor activation
Autor: Sinéad Kinsella, Cindy A. Evandy, Kirsten Cooper, Antonella Cardinale, Lorenzo Iovino, Paul deRoos, Kayla S. Hopwo, Colton W. Smith, David Granadier, Lucas B. Sullivan, Enrico Velardi, Jarrod A. Dudakov
Endogenous thymic regeneration is a crucial process that allows for the renewal of immune competence following stress, infection or cytoreductive conditioning. Fully understanding the molecular mechanisms driving regeneration will uncover therapeutic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::18efc9a131627f508f25e89f68542965
https://doi.org/10.1101/2023.01.19.524800
Zobrazit plný text záznamu
10
Targeting PDAC metabolism: Environment determines what has GOT2 give
Autor: Oliver J. Newsom, Lucas B. Sullivan
Publikováno v: Cell metabolism. 34(11)
Metabolic disruption is a mainstay of cancer therapy, prompting research aimed at identifying novel metabolic targets. Despite strong effects observed in culture, three recent studies found pancreatic tumors are refractory to disruption of the metabo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a99e7298d426f9382aa884e02090149
https://pubmed.ncbi.nlm.nih.gov/36323232
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje