Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Lucas B, Dillard"'
Autor:
Monica C. Pillon, Meredith N. Frazier, Lucas B. Dillard, Jason G. Williams, Seda Kocaman, Juno M. Krahn, Lalith Perera, Cassandra K. Hayne, Jacob Gordon, Zachary D. Stewart, Mack Sobhany, Leesa J. Deterding, Allen L. Hsu, Venkata P. Dandey, Mario J. Borgnia, Robin E. Stanley
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nsp15 is a uridine specific endoribonuclease present in all coronaviruses. Here, the authors determine the cryo-EM structures of SARS-CoV-2 Nsp15 in the apo and UTP-bound states, which together with biochemical experiments, mass spectrometry and mole
Externí odkaz:
https://doaj.org/article/3b3bd68422cc4508a02721056de1a082
Autor:
Bradley P, Klemm, Deepa, Singh, Cassandra E, Smith, Allen L, Hsu, Lucas B, Dillard, Juno M, Krahn, Robert E, London, Geoffrey A, Mueller, Mario J, Borgnia, Roel M, Schaaper
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(37)
Levels of the cellular dNTPs, the direct precursors for DNA synthesis, are important for DNA replication fidelity, cell cycle control, and resistance against viruses.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6f8f7ec4e6a8fb59038bd37189953473
https://pubmed.ncbi.nlm.nih.gov/36067314
https://pubmed.ncbi.nlm.nih.gov/36067314
Autor:
Bradley P. Klemm, Deepa Singh, Cassandra E. Smith, Allen L. Hsu, Lucas B. Dillard, Juno M. Krahn, Robert E. London, Geoffrey A. Mueller, Mario J. Borgnia, Roel M. Schaaper
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Levels of the cellular dNTPs, the direct precursors for DNA synthesis, are important for DNA replication fidelity, cell cycle control, and resistance against viruses. Escherichia coli encodes a dGTPase (2′-deoxyguanosine-5′-triphosphate [dGTP] tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a4e42da2ab3f1e7ea98051372b7c643
https://doi.org/10.1073/pnas.2123092119
https://doi.org/10.1073/pnas.2123092119
Autor:
Urmi Sengupta, Lucas B. Dillard, Fatemeh Abbasi Yeganeh, Kwang Hun Lim, Nadia Daneshparvar, Robert G. Griffin, Kenneth A. Taylor, Dianne W. Taylor, Brian Michael, Mario J. Borgnia, Alimohammad Hojjatian, Anvesh K. R. Dasari, Rakez Kayed
Publikováno v:
Biochem Biophys Res Commun
Recent structural investigation of amyloid filaments extracted from human patients demonstrated that the ex vivo filaments associated with different disease phenotypes adopt diverse molecular conformations, which are different from those of in vitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d05d626826c19493349a3f8494b23aa
https://doi.org/10.1016/j.bbrc.2021.03.091
https://doi.org/10.1016/j.bbrc.2021.03.091
Autor:
Meredith N. Frazier, Isha M. Wilson, Juno M. Krahn, Kevin John Butay, Lucas B. Dillard, Mario J. Borgnia, Robin E. Stanley
Publikováno v:
Nucleic Acids Res
Coronaviruses generate double-stranded (ds) RNA intermediates during viral replication that can activate host immune sensors. To evade activation of the host pattern recognition receptor MDA5, coronaviruses employ Nsp15, which is a uridine-specific e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfa419dff28c4a17f6ffe328c90ac4b4
https://pubmed.ncbi.nlm.nih.gov/35262076
https://pubmed.ncbi.nlm.nih.gov/35262076
Autor:
Kwang Hun Lim, Kenneth A. Taylor, Anvesh K. R. Dasari, Urmi Sengupta, Mario J. Borgnia, Lucas B. Dillard, Alimohammad Hojjatian, Rakez Kayed
Accumulation of filamentous aggregates of α-synuclein is a pathological hallmark of several neurodegenerative diseases including Parkinson’s disease (PD). Interaction between α-synuclein and lipids has been shown to play a critical role in aggreg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f777ae817abf620947e3c2fdf7fdc67
https://doi.org/10.1101/2021.10.19.464986
https://doi.org/10.1101/2021.10.19.464986
Autor:
Mario J. Borgnia, Leesa J. Deterding, Robin E. Stanley, Lucas B. Dillard, Juno M. Krahn, Monica C. Pillon, Lalith Perera, Isha M Wilson, Jason Williams, Zachary D. Stewart, Meredith N Frazier
Nsp15 is a uridine specific endoribonuclease that coronaviruses employ to cleave viral RNA and evade host immune defense systems. Previous structures of Nsp15 from across Coronaviridae revealed that Nsp15 assembles into a homo-hexamer and has a conse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d29d1330e1e81e5cf908f6dcc3034c3
https://doi.org/10.1101/2021.06.01.446181
https://doi.org/10.1101/2021.06.01.446181
Autor:
Lucas B. Dillard, Cassandra K. Hayne, Meredith N Frazier, Lalith Perera, Robin E. Stanley, Allen L. Hsu, Leesa J. Deterding, Jason Williams, Zachary D. Stewart, Mario J. Borgnia, Jacob Gordon, Venkata P. Dandey, Monica C. Pillon, Mack Sobhany, Seda Kocaman, Juno M. Krahn
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
bioRxiv
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
bioRxiv
Nsp15, a uridine specific endoribonuclease conserved across coronaviruses, processes viral RNA to evade detection by host defense systems. Crystal structures of Nsp15 from different coronaviruses have shown a common hexameric assembly, yet how the en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fd88fa61a41e36bf913df39126d8bfb
Autor:
Urmi Sengupta, Kwang Hun Lim, Mario J. Borgnia, Kenneth A. Taylor, Dianne W. Taylor, Lucas B. Dillard, Brian Michael, Alimohammad Hojjatian, Anvesh K. R. Dasari, Nadia Daneshparvar, Robert G. Griffin, Rakez Kayed, Fatemeh Abbasi Yeganeh
Recent structural studies of ex vivo amyloid filaments extracted from human patients demonstrated that the ex vivo filaments associated with different disease phenotypes adopt diverse molecular conformations distinct from those in vitro amyloid filam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c99f38ac9ec7def6d7cda93a4b637a26
https://doi.org/10.1101/2020.12.31.424989
https://doi.org/10.1101/2020.12.31.424989
Autor:
Monica C. Pillon, Meredith N. Frazier, Lucas B. Dillard, Jason G. Williams, Seda Kocaman, Juno M. Krahn, Lalith Perera, Cassandra K. Hayne, Jacob Gordon, Zachary D. Stewart, Mack Sobhany, Leesa J. Deterding, Allen L. Hsu, Venkata P. Dandey, Mario J. Borgnia, Robin E. Stanley
Publikováno v:
Nature Communications
Nsp15, a uridine specific endoribonuclease conserved across coronaviruses, processes viral RNA to evade detection by host defense systems. Crystal structures of Nsp15 from different coronaviruses have shown a common hexameric assembly, yet how the en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c681bcbdd8d24dd78f6f58a25417f339
https://pubmed.ncbi.nlm.nih.gov/33504779
https://pubmed.ncbi.nlm.nih.gov/33504779