Associations in cell type-specific hydroxymethylation and transcriptional alterations of pediatric central nervous system tumors

Autor: Min Kyung Lee, Nasim Azizgolshani, Ze Zhang, Laurent Perreard, Fred W. Kolling, Lananh N. Nguyen, George J. Zanazzi, Lucas A. Salas, Brock C. Christensen

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)

Abstract Although intratumoral heterogeneity has been established in pediatric central nervous system tumors, epigenomic alterations at the cell type level have largely remained unresolved. To identify cell type-specific alterations to cytosine modif

Externí odkaz: https://doaj.org/article/0f056dd83a1c4f31861e1c0484d38c51

Tumor microenvironment deconvolution identifies cell-type-independent aberrant DNA methylation and gene expression in prostate cancer

Autor: Samuel R. Reynolds, Ze Zhang, Lucas A. Salas, Brock C. Christensen

Publikováno v: Clinical Epigenetics, Vol 16, Iss 1, Pp 1-15 (2024)

Abstract Background Among men, prostate cancer (PCa) is the second most common cancer and the second leading cause of cancer death. Etiologic factors associated with both prostate carcinogenesis and somatic alterations in tumors are incompletely unde

Externí odkaz: https://doaj.org/article/2f55d7e66f2e476f80b4ae2313318851

Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude

Autor: Latha Kadalayil, Md. Zahangir Alam, Cory Haley White, Akram Ghantous, Esther Walton, Olena Gruzieva, Simon Kebede Merid, Ashish Kumar, Ritu P. Roy, Olivia Solomon, Karen Huen, Brenda Eskenazi, Peter Rzehak, Veit Grote, Jean-Paul Langhendries, Elvira Verduci, Natalia Ferre, Darek Gruszfeld, Lu Gao, Weihua Guan, Xuehuo Zeng, Enrique F. Schisterman, John F. Dou, Kelly M. Bakulski, Jason I. Feinberg, Munawar Hussain Soomro, Giancarlo Pesce, Nour Baiz, Elena Isaevska, Michelle Plusquin, Marina Vafeiadi, Theano Roumeliotaki, Sabine A. S. Langie, Arnout Standaert, Catherine Allard, Patrice Perron, Luigi Bouchard, Evelien R. van Meel, Janine F. Felix, Vincent W. V. Jaddoe, Paul D. Yousefi, Cecilia H. Ramlau-Hansen, Caroline L. Relton, Elmar W. Tobi, Anne P. Starling, Ivana V. Yang, Maria Llambrich, Gillian Santorelli, Johanna Lepeule, Lucas A. Salas, Mariona Bustamante, Susan L. Ewart, Hongmei Zhang, Wilfried Karmaus, Stefan Röder, Ana Claudia Zenclussen, Jianping Jin, Wenche Nystad, Christian M. Page, Maria Magnus, Dereje D. Jima, Cathrine Hoyo, Rachel L. Maguire, Tuomas Kvist, Darina Czamara, Katri Räikkönen, Tong Gong, Vilhelmina Ullemar, Sheryl L. Rifas-Shiman, Emily Oken, Catarina Almqvist, Robert Karlsson, Jari Lahti, Susan K. Murphy, Siri E. Håberg, Stephanie London, Gunda Herberth, Hasan Arshad, Jordi Sunyer, Regina Grazuleviciene, Dana Dabelea, Régine P. M. Steegers-Theunissen, Ellen A. Nohr, Thorkild I. A. Sørensen, Liesbeth Duijts, Marie-France Hivert, Vera Nelen, Maja Popovic, Manolis Kogevinas, Tim S. Nawrot, Zdenko Herceg, Isabella Annesi-Maesano, M. Daniele Fallin, Edwina Yeung, Carrie V. Breton, Berthold Koletzko, Nina Holland, Joseph L. Wiemels, Erik Melén, Gemma C. Sharp, Matt J. Silver, Faisal I. Rezwan, John W. Holloway

Publikováno v: Clinical Epigenetics, Vol 15, Iss 1, Pp 1-23 (2023)

Abstract Background Seasonal variations in environmental exposures at birth or during gestation are associated with numerous adult traits and health outcomes later in life. Whether DNA methylation (DNAm) plays a role in the molecular mechanisms under

Externí odkaz: https://doaj.org/article/d655547609c94f51b01a2521002c970a

Assessment of immune cell profiles among post-menopausal women in the Women’s Health Initiative using DNA methylation-based methods

Autor: Emily Nissen, Alexander Reiner, Simin Liu, Robert B. Wallace, Annette M. Molinaro, Lucas A. Salas, Brock C. Christensen, John K. Wiencke, Devin C. Koestler, Karl T. Kelsey

Publikováno v: Clinical Epigenetics, Vol 15, Iss 1, Pp 1-16 (2023)

Abstract Background Over the past decade, DNA methylation (DNAm)-based deconvolution methods that leverage cell-specific DNAm markers of immune cell types have been developed to provide accurate estimates of the proportions of leukocytes in periphera

Externí odkaz: https://doaj.org/article/208d74f53e1241a0b7e56fbcf8f4dbbb

DNA methylation as a pharmacodynamic marker of glucocorticoid response and glioma survival

Autor: J. K. Wiencke, Annette M. Molinaro, Gayathri Warrier, Terri Rice, Jennifer Clarke, Jennie W. Taylor, Margaret Wrensch, Helen Hansen, Lucie McCoy, Emily Tang, Stan J. Tamaki, Courtney M. Tamaki, Emily Nissen, Paige Bracci, Lucas A. Salas, Devin C. Koestler, Brock C. Christensen, Ze Zhang, Karl T. Kelsey

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)

Glucocorticoids, such as dexamethasone, are used as anti-inflammatory and immunosuppressive drugs, however patients may exhibit resistance or side effects. Here the authors propose that a dexamethasone related neutrophil-specific DNA methylation inde

Externí odkaz: https://doaj.org/article/8c78f67ff3fe480fa4daea5990680400