Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Lucas A Maddalena"'
Autor:
Connor Rogerson, Marco Sciacovelli, Lucas A. Maddalena, Andromachi Pouikli, Marc Segarra-Mondejar, Lorea Valcarcel-Jimenez, Christina Schmidt, Ming Yang, Elena Ivanova, Joshua Kent, Ariane Mora, Danya Cheeseman, Jason S. Carroll, Gavin Kelsey, Christian Frezza
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112751- (2023)
Summary: Hereditary leiomyomatosis and renal cell cancer (HLRCC) is a cancer syndrome caused by inactivating germline mutations in fumarate hydratase (FH) and subsequent accumulation of fumarate. Fumarate accumulation leads to profound epigenetic cha
Externí odkaz:
https://doaj.org/article/4a018807958940d294037e2083e5da34
Autor:
Horácio N. Hastenreiter Filho, Igor T. Peres, Lucas G. Maddalena, Fernanda A. Baião, Otavio T. Ranzani, Silvio Hamacher, Paula M. Maçaira, Fernando A. Bozza
Publikováno v:
Frontiers in Public Health, Vol 11 (2023)
BackgroundThe lack of precise definitions and terminological consensus about the impact studies of COVID-19 vaccination leads to confusing statements from the scientific community about what a vaccination impact study is.ObjectiveThe present work pre
Externí odkaz:
https://doaj.org/article/576b0399f94a4ff78252ce931ab12b86
Autor:
Katie A. O’Brien, Ben D. McNally, Alice P. Sowton, Antonio Murgia, James Armitage, Luke W. Thomas, Fynn N. Krause, Lucas A. Maddalena, Ian Francis, Stefan Kavanagh, Dominic P. Williams, Margaret Ashcroft, Julian L. Griffin, Jonathan J. Lyon, Andrew J. Murray
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-20 (2021)
Abstract Background Tissue hypoxia is a key feature of several endemic hepatic diseases, including alcoholic and non-alcoholic fatty liver disease, and organ failure. Hypoxia imposes a severe metabolic challenge on the liver, potentially disrupting i
Externí odkaz:
https://doaj.org/article/e6fa613deccb4bec8cc1aae51e72dedf
Autor:
Luke W. Thomas, Cinzia Esposito, Rachel E. Morgan, Stacey Price, Jamie Young, Steven P. Williams, Lucas A. Maddalena, Ultan McDermott, Margaret Ashcroft
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Thomas, Ashcroft and colleagues use genome-wide CRISPR/Cas9 screening under tumour-relevant metabolic conditions to identify genes that are essential in cancer. Mitochondrial gene essentiality is highlighted, and routes for regulating tumour cell via
Externí odkaz:
https://doaj.org/article/bf0028ba8d264de48beb6836642740d8
Autor:
Thomas Briston, Jenna M. Stephen, Luke W. Thomas, Cinzia Esposito, Yuen-Li Chung, Saiful E. Syafruddin, Mark Turmaine, Lucas A. Maddalena, Basma Greef, Gyorgy Szabadkai, Patrick H. Maxwell, Sakari Vanharanta, Margaret Ashcroft
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Externí odkaz:
https://doaj.org/article/b7f2645f5c1d4560acb8806d154ef118
Autor:
Thomas Briston, Jenna M. Stephen, Luke W. Thomas, Cinzia Esposito, Yuen-Li Chung, Saiful E. Syafruddin, Mark Turmaine, Lucas A. Maddalena, Basma Greef, Gyorgy Szabadkai, Patrick H. Maxwell, Sakari Vanharanta, Margaret Ashcroft
Publikováno v:
Frontiers in Oncology, Vol 8 (2018)
Dysregulated mitochondrial function is associated with the pathology of a wide range of diseases including renal disease and cancer. Thus, investigating regulators of mitochondrial function is of particular interest. Previous work has shown that the
Externí odkaz:
https://doaj.org/article/e72df2ce0a76477190094194414fb2d1
Autor:
Connor Rogerson, Marco Sciacovelli, Lucas A Maddalena, Lorea Valcarcel-Jimenez, Christina Schmidt, Ming Yang, Elena Ivanova, Joshua Kent, Ariane Mora, Danya Cheeseman, Jason S Carroll, Gavin Kelsey, Christian Frezza
Hereditary Leiomyomatosis and renal cell cancer (HLRCC) is a cancer syndrome caused by inactivating germline mutations in fumarate hydratase (FH) and subsequent accumulation of fumarate. Fumarate accumulation leads to the activation of an anti-oxidan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d597dfc3cdcb4747096b4dc97bc774c6
https://doi.org/10.1101/2022.07.04.498412
https://doi.org/10.1101/2022.07.04.498412
Autor:
Nigel Kurgan, Kennedy C. Whitley, Lucas A. Maddalena, Fereshteh Moradi, Joshua Stoikos, Sophie I. Hamstra, Elizabeth A. Rubie, Megha Kumar, Brian D. Roy, James R. Woodgett, Jeffrey A. Stuart, Val A. Fajardo
Publikováno v:
Cells, Vol 8, Iss 11, p 1340 (2019)
Glycogen synthase kinase 3 (GSK3) slows myogenic differentiation and myoblast fusion partly by inhibiting the Wnt/β-catenin signaling pathway. Lithium, a common medication for bipolar disorder, inhibits GSK3 via Mg+ competition and increased Ser21 (
Externí odkaz:
https://doaj.org/article/dc36e0636c20424e8b1944f2b723ce52
Autor:
Mia S, Geromella, Chantal R, Ryan, Jessica L, Braun, Michael S, Finch, Lucas A, Maddalena, Olivia, Bagshaw, Briana L, Hockey, Fereshteh, Moradi, Rachel K, Fenech, Jisook, Ryoo, Daniel M, Marko, Roopan, Dhaliwal, Jake, Sweezey-Munroe, Sophie I, Hamstra, Georgina, Gardner, Sebastian, Silvera, Rene, Vandenboom, Brian D, Roy, Jeffrey A, Stuart, Rebecca E K, MacPherson, Val A, Fajardo
Publikováno v:
The Journal of biological chemistry. 298(11)
Sarco(endo)plasmic reticulum Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7819e39b049f7a1c198135e82039e14e
https://pubmed.ncbi.nlm.nih.gov/36209826
https://pubmed.ncbi.nlm.nih.gov/36209826