Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Lucas, Dennis"'
Autor:
Daniel R Zollinger, Elizabeth Rivers, Alexander Fine, Yanmei Huang, Joseph Son, Akshita Kalyan, Wren Gray, Golshid Baharian, Carly Hammond, Rosalyn Ram, Lindsay Ringman, Dina Hafez, Daniel Savel, Vipul Patel, Marc Dantone, Cui Guo, Merrida Childress, Chang Xu, Dorhyun Johng, Brett Wallden, Prapti Pokharel, William Camara, Priti S Hegde, Jason Hughes, Corey Carter, Nicole Davarpanah, Viraj Degaonkar, Pratyush Gupta, Sanjeev Mariathasan, Thomas Powles, Sean Ferree, Lucas Dennis, Amanda Young
Publikováno v:
PLoS ONE, Vol 19, Iss 5, p e0302129 (2024)
Emerging technologies focused on the detection and quantification of circulating tumor DNA (ctDNA) in blood show extensive potential for managing patient treatment decisions, informing risk of recurrence, and predicting response to therapy. Currently
Externí odkaz:
https://doaj.org/article/3fc28d0921b64f258d166f8cdf7339fa
Autor:
Smruthy Sivakumar, Dexter X. Jin, Hanna Tukachinsky, Karthikeyan Murugesan, Kimberly McGregor, Natalie Danziger, Dean Pavlick, Ole Gjoerup, Jeffrey S. Ross, Robert Harmon, Jon Chung, Brennan Decker, Lucas Dennis, Garrett M. Frampton, Luciana Molinero, Steffi Oesterreich, Jeffrey M. Venstrom, Geoffrey R. Oxnard, Priti S. Hegde, Ethan S. Sokol
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Liquid biopsies could be valuable tools to monitor breast cancer progression and evolution. Here, the authors investigate genomic profiling of tissue and liquid biopsies in a large cohort of patients with breast cancer during the course of therapy to
Externí odkaz:
https://doaj.org/article/b3aeff304c474e6c83d5647b3e086870
Autor:
Rafal Dziadziuszko, Tiffany Hung, Kun Wang, Voleak Choeurng, Alexander Drilon, Robert C. Doebele, Fabrice Barlesi, Charlie Wu, Lucas Dennis, Joel Skoletsky, Ryan Woodhouse, Meijuan Li, Ching‐Wei Chang, Brian Simmons, Todd Riehl, Timothy R. Wilson
Publikováno v:
Molecular Oncology, Vol 16, Iss 10, Pp 2000-2014 (2022)
Genomic tumour profiling informs targeted treatment options. Entrectinib is a tyrosine kinase inhibitor with efficacy in NTRK fusion‐positive (‐fp) solid tumours and ROS1‐fp non‐small cell lung cancer. FoundationOne® Liquid CDx (F1L CDx), a
Externí odkaz:
https://doaj.org/article/70c5cd67899f40a68e40335c1c0b149a
Autor:
Ryan Woodhouse, Meijuan Li, Jason Hughes, David Delfosse, Joel Skoletsky, Pei Ma, Wei Meng, Ninad Dewal, Coren Milbury, Travis Clark, Amy Donahue, Dan Stover, Mark Kennedy, Jennifer Dacpano-Komansky, Christine Burns, Christine Vietz, Brian Alexander, Priti Hegde, Lucas Dennis
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0237802 (2020)
As availability of precision therapies expands, a well-validated circulating cell-free DNA (cfDNA)-based comprehensive genomic profiling assay has the potential to provide considerable value as a complement to tissue-based testing to ensure potential
Externí odkaz:
https://doaj.org/article/c9d36c35db194ad48647b611d39f7516
Autor:
Geoffrey R. Oxnard, Jeffrey M. Venstrom, Andrea Loehr, Andrew Simmons, Simon P. Watkins, Tony Golsorkhi, Karim Fizazi, Charles J. Ryan, Simon Chowdhury, Wassim Abida, Brian M. Alexander, Jeffrey S. Ross, Ryon P. Graf, Lei Zhong, Samantha Morley, Bernard J. Fendler, Lucas Dennis, Eric A. Severson, Ole V. Gjoerup, Jon H. Chung, Russell W. Madison, Hanna Tukachinsky
Ratio of detection rates in liquid versus tissue.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fde02073d3933b7b0389f15995e8528
https://doi.org/10.1158/1078-0432.22479377
https://doi.org/10.1158/1078-0432.22479377
Autor:
Geoffrey R. Oxnard, Jeffrey M. Venstrom, Andrea Loehr, Andrew Simmons, Simon P. Watkins, Tony Golsorkhi, Karim Fizazi, Charles J. Ryan, Simon Chowdhury, Wassim Abida, Brian M. Alexander, Jeffrey S. Ross, Ryon P. Graf, Lei Zhong, Samantha Morley, Bernard J. Fendler, Lucas Dennis, Eric A. Severson, Ole V. Gjoerup, Jon H. Chung, Russell W. Madison, Hanna Tukachinsky
Purpose:Comprehensive genomic profiling (CGP) is of increasing value for patients with metastatic castration-resistant prostate cancer (mCRPC). mCRPC tends to metastasize to bone, making tissue biopsies challenging to obtain. We hypothesized CGP of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1374415426973feb5f3438889ce16726
https://doi.org/10.1158/1078-0432.c.6530201.v1
https://doi.org/10.1158/1078-0432.c.6530201.v1
Autor:
Geoffrey R. Oxnard, Jeffrey M. Venstrom, Andrea Loehr, Andrew Simmons, Simon P. Watkins, Tony Golsorkhi, Karim Fizazi, Charles J. Ryan, Simon Chowdhury, Wassim Abida, Brian M. Alexander, Jeffrey S. Ross, Ryon P. Graf, Lei Zhong, Samantha Morley, Bernard J. Fendler, Lucas Dennis, Eric A. Severson, Ole V. Gjoerup, Jon H. Chung, Russell W. Madison, Hanna Tukachinsky
Positive percent agreement (PPA) between patient-matched cancer tissue and liquid biopsies.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c9134157cc93c1caa07f26280fac657
https://doi.org/10.1158/1078-0432.22479359
https://doi.org/10.1158/1078-0432.22479359
Autor:
Eric Allan Severson, Ole Gjoerup, Jeffrey M. Venstrom, Lucas Dennis, Douglas I. Lin, Daniel Duncan, Lei Yang, Jonathan Keith Killian, Jeffrey S. Ross, Shakti H. Ramkissoon, Dean Pavlick, Geoff Oxnard, Richard S.P. Huang, Julia A. Elvin, Jinpeng Xiao, Bernard Fendler, Matthew Hiemenz, Cui Guo, Aparna Aiyer, Dexter X. Jin
Publikováno v:
Clinical Chemistry. 67:1554-1566
Background The amounts of circulating cell-free DNA (cfDNA) and circulating-tumor DNA (ctDNA) present in peripheral blood liquid biopsies can vary due to preanalytic/analytic variables. In this study, we examined the impact of patient age, sex, stage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf5dc9ee1f92ebc08aa923e47fdf6926
https://doi.org/10.1093/clinchem/hvab176
https://doi.org/10.1093/clinchem/hvab176
Autor:
Andrew Simmons, Charles J. Ryan, Simon Chowdhury, Bernard Fendler, Jon Chung, Wassim Abida, Ryon Graf, Hanna Tukachinsky, Jeffrey S. Ross, Andrea Loehr, Tony Golsorkhi, Karim Fizazi, Jeffrey M. Venstrom, Russell Madison, Lucas Dennis, Samantha Morley, Ole Gjoerup, Geoffrey R. Oxnard, Brian M. Alexander, Lei Zhong, Eric Allan Severson, Simon Paul Watkins
Publikováno v:
Clinical Cancer Research. 27:3094-3105
Purpose: Comprehensive genomic profiling (CGP) is of increasing value for patients with metastatic castration-resistant prostate cancer (mCRPC). mCRPC tends to metastasize to bone, making tissue biopsies challenging to obtain. We hypothesized CGP of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae4712211618ae7e9a51564f3cdf5f75
https://doi.org/10.1158/1078-0432.ccr-20-4805
https://doi.org/10.1158/1078-0432.ccr-20-4805
Autor:
Kunle Odunsi, Feng Qian, Amit A. Lugade, Han Yu, Melissa A. Geller, Steven P. Fling, Judith C. Kaiser, Andreanne M. Lacroix, Leonard D’Amico, Nirasha Ramchurren, Chihiro Morishima, Mary L. Disis, Lucas Dennis, Patrick Danaher, Sarah Warren, Van Anh Nguyen, Sudharshan Ravi, Takemasa Tsuji, Spencer Rosario, Wenjuan Zha, Alan Hutson, Song Liu, Shashikant Lele, Emese Zsiros, A. J. Robert McGray, Jessie Chiello, Richard Koya, Thinle Chodon, Carl D. Morrison, Vasanta Putluri, Nagireddy Putluri, Donald E. Mager, Rudiyanto Gunawan, Martin A. Cheever, Sebastiano Battaglia, Junko Matsuzaki
Publikováno v:
Sci Transl Med
To uncover underlying mechanisms associated with failure of indoleamine 2,3-dioxygenase 1 (IDO1) blockade in clinical trials, we conducted a pilot, window-of-opportunity clinical study in 17 patients with newly diagnosed advanced high-grade serous ov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac8e43c1970974a5d2ecf993085e3805
https://pubmed.ncbi.nlm.nih.gov/35294258
https://pubmed.ncbi.nlm.nih.gov/35294258