Multiomic ALS signatures highlight subclusters and sex differences suggesting the MAPK pathway as therapeutic target

Autor: Lucas Caldi Gomes, Sonja Hänzelmann, Fabian Hausmann, Robin Khatri, Sergio Oller, Mojan Parvaz, Laura Tzeplaeff, Laura Pasetto, Marie Gebelin, Melanie Ebbing, Constantin Holzapfel, Stefano Fabrizio Columbro, Serena Scozzari, Johanna Knöferle, Isabell Cordts, Antonia F. Demleitner, Marcus Deschauer, Claudia Dufke, Marc Sturm, Qihui Zhou, Pavol Zelina, Emma Sudria-Lopez, Tobias B. Haack, Sebastian Streb, Magdalena Kuzma-Kozakiewicz, Dieter Edbauer, R. Jeroen Pasterkamp, Endre Laczko, Hubert Rehrauer, Ralph Schlapbach, Christine Carapito, Valentina Bonetto, Stefan Bonn, Paul Lingor

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)

Abstract Amyotrophic lateral sclerosis (ALS) is a debilitating motor neuron disease and lacks effective disease-modifying treatments. This study utilizes a comprehensive multiomic approach to investigate the early and sex-specific molecular mechanism

Externí odkaz: https://doaj.org/article/a01f4f133f534a40923cc24277e82506

MicroRNAs from extracellular vesicles as a signature for Parkinson's disease

Autor: Lucas Caldi Gomes, Anna‐Elisa Roser, Gaurav Jain, Tonatiuh Pena Centeno, Fabian Maass, Lukas Schilde, Caroline May, Anja Schneider, Mathias Bähr, Katrin Marcus, André Fischer, Paul Lingor

Publikováno v: Clinical and Translational Medicine, Vol 11, Iss 4, Pp n/a-n/a (2021)

Externí odkaz: https://doaj.org/article/c151f27825af4db1ada11e723cb80efa

Circulating miRNAs as Diagnostic Biomarkers for Parkinson’s Disease

Autor: Anna Elisa Roser, Lucas Caldi Gomes, Jonas Schünemann, Fabian Maass, Paul Lingor

Publikováno v: Frontiers in Neuroscience, Vol 12 (2018)

Parkinson’s disease (PD) is the second most common neurodegenerative disorder worldwide. Its main neuropathological hallmarks are the degeneration of dopaminergic neurons in the substantia nigra and alpha-synuclein containing protein inclusions, ca

Externí odkaz: https://doaj.org/article/bf213ab479984b0d86946806f7cba339

miR-182-5p and miR-183-5p Act as GDNF Mimics in Dopaminergic Midbrain Neurons

Autor: Lucas Caldi Gomes, Gaurav Jain, Lars Tatenhorst, Anna-Elisa Roser, Fabian Maass, Rashi Halder, Andre Fischer, Lars Tönges, Paul Lingor, Mathias Bähr

Publikováno v: Molecular Therapy. Nucleic Acids
Molecular Therapy: Nucleic Acids, Vol 11, Iss C, Pp 9-22 (2018)
Molecular Therapy: Nucleic Acids. Elsevier (2018).
Molecular Therapy / Nucleic Acids 11, 9-22 (2018). doi:10.1016/j.omtn.2018.01.005

Parkinson's disease (PD) is the second-most-frequent neurodegenerative disorder worldwide. One major hallmark of PD is the degeneration of dopaminergic (DA) neurons in the substantia nigra. Glial cell line-derived neurotrophic factor (GDNF) potently

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ff8b2f6d989efaead4db0239b111b3e
http://europepmc.org/articles/PMC5849806

Alpha-synuclein deregulates the expression of COL4A2 and impairs ER-Golgi function

Autor: Diana F. Lázaro, Cemil Kerimoglu, Fran Borovečki, Éva M. Szegő, Mary Xylaki, Isabel Paiva, Susanne Burkhardt, Vincenzo Capece, Rezaul Islam, Anna Elisa Roser, Raquel Pinho, Kristina Gotovac Jerčić, Lucas Caldi Gomes, Gaurav Jain, Thomas Hentrich, Rashi Halder, Andre Fischer, Tiago F. Outeiro, Paul Lingor, Julia M. Schulze-Hentrich

Publikováno v: Neurobiology of disease 119, 121-135 (2018). doi:10.1016/j.nbd.2018.08.001
Neurobiology of Disease, Vol 119, Iss, Pp 121-135 (2018)

Alpha-synuclein (aSyn) is the major protein component of Lewy bodies and Lewy neurites, the typical pathological hallmarks in Parkinson's disease (PD) and Dementia with Lewy bodies. aSyn is capable of inducing transcriptional deregulation, but the pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4856515c5d060014e6e2822ce53976df