Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Luca Zangrandi"'
Autor:
Luca Zangrandi, Barbara Fogli, Anna Mutti, René Staritzbichler, Victoria Most, Peter W. Hildebrand, Regine Heilbronn, Christoph Schwarzer
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Dynorphins (Dyn) represent the subset of endogenous opioid peptides with the highest binding affinity to kappa opioid receptors (KOPrs). Activation of the G-protein-coupled pathway of KOPrs has strong anticonvulsant effects. Dyn also bind to mu (MOPr
Externí odkaz:
https://doaj.org/article/f369c9268e654a14b335b6273d0e7f09
Autor:
Alexandra S Agostinho, Mario Mietzsch, Luca Zangrandi, Iwona Kmiec, Anna Mutti, Larissa Kraus, Pawel Fidzinski, Ulf C Schneider, Martin Holtkamp, Regine Heilbronn, Christoph Schwarzer
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 10, Pp 1-16 (2019)
Abstract Focal epilepsy represents one of the most common chronic CNS diseases. The high incidence of drug resistance, devastating comorbidities, and insufficient responsiveness to surgery pose unmet medical challenges. In the quest of novel, disease
Externí odkaz:
https://doaj.org/article/480489b3db774418b348f8ecb6933d15
Autor:
Andreas Lieb, Germana Thaler, Barbara Fogli, Olga Trovato, Mitja Amon Posch, Teresa Kaserer, Luca Zangrandi
Publikováno v:
Biomedicines, Vol 9, Iss 12, p 1882 (2021)
Mutations in the prodynorphin gene (PDYN) are associated with the development of spinocerebellar ataxia type 23 (SCA23). Pathogenic missense mutations are localized predominantly in the PDYN region coding for the dynorphin A (DynA) neuropeptide and l
Externí odkaz:
https://doaj.org/article/c0f158f0cc8d422190baa66a5ae0f968
Autor:
Johannes Burtscher, Camilla Bean, Luca Zangrandi, Iwona Kmiec, Alexandra Agostinho, Luca Scorrano, Erich Gnaiger, Christoph Schwarzer
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
Epilepsies are a group of common neurological diseases exerting a strong burden on patients and society, often lacking clear etiology and effective therapeutical strategies. Early intervention during the development of epilepsy (epileptogenesis) is o
Externí odkaz:
https://doaj.org/article/a5ba7cb3ca2a47208a4b973e826b06a5
Autor:
Daniela Weth-Malsch, Michiel Langeslag, Dimitra Beroukas, Luca Zangrandi, Iris Kastenberger, Serena Quarta, Philipp Malsch, Theodora Kalpachidou, Christoph Schwarzer, Richard L Proia, Rainer Viktor Haberberger, Michaela Kress
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 10 (2016)
Understanding the role of the bioactive lipid mediator sphingosine 1-phosphate (S1P) within the central nervous system has recently gained more and more attention, as it has been connected to major diseases such as multiple sclerosis and Alzheimer's
Externí odkaz:
https://doaj.org/article/00d27de793e0415685ac6c044cd4fc1d
Autor:
Carla Letizia Busceti, Domenico Bucci, Gemma Molinaro, Paola Di Pietro, Luca Zangrandi, Roberto Gradini, Rosario Moratalla, Giuseppe Battaglia, Valeria Bruno, Ferdinando Nicoletti, Francesco Fornai
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44025 (2012)
We examined the role of endogenous dopamine (DA) in regulating the number of intrinsic tyrosine hydroxylase-positive (TH(+)) striatal neurons using mice at postnatal day (PND) 4 to 8, a period that corresponds to the developmental peak in the number
Externí odkaz:
https://doaj.org/article/6da1b2f0862e41f485d504302ead7c11
Autor:
Luca, Zangrandi, Christoph, Schwarzer
Publikováno v:
Handbook of experimental pharmacology. 271
Temporal lobe epilepsy is considered to be one of the most common and severe forms of focal epilepsies. Patients frequently develop cognitive deficits and emotional blunting along progression of the disease. The high incidence of refractoriness to an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a202aa10468a50c7d9182004f729fbf8
https://pubmed.ncbi.nlm.nih.gov/33712941
https://pubmed.ncbi.nlm.nih.gov/33712941
Autor:
Luca Zangrandi, Christoph Schwarzer
Publikováno v:
The Kappa Opioid Receptor ISBN: 9783030890735
Temporal lobe epilepsy is considered to be one of the most common and severe forms of focal epilepsies. Patients frequently develop cognitive deficits and emotional blunting along progression of the disease. The high incidence of refractoriness to an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::195be398984b2dd0c1032de80db41632
https://doi.org/10.1007/164_2021_444
https://doi.org/10.1007/164_2021_444
Autor:
Alba Di Pardo, Christoph Schwarzer, Luca Zangrandi, Vittorio Maglione, Grégoire P. Millet, Johannes Burtscher
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 582, p 582 (2021)
International Journal of Molecular Sciences, Vol 22, Iss 582, p 582 (2021)
Neurodegenerative diseases are characterized by adverse cellular environments and pathological alterations causing neurodegeneration in distinct brain regions. This development is triggered or facilitated by conditions such as hypoxia, ischemia or in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dad0a4700c49c7ba059930995356b951
http://europepmc.org/articles/PMC7826574
http://europepmc.org/articles/PMC7826574
Autor:
Luca Zangrandi, Lee-Yuan Liu-Chen, Matthias Mann, Sean J. Humphrey, Mariana Spetea, Kirti Sharma, Jeffrey J. Liu, Christoph Schwarzer, Yi-Ting Chiu, Chongguang Chen
Publikováno v:
Science
Obtaining a systems view of G protein-coupled receptor (GPCR) signaling in its native environment is the key in development of GPCR therapeutics with fewer side effects. Using the kappa opioid receptor (KOR), a model GPCR, we employed high-throughput
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0af85569d03678dacea28a74acc54fa
https://europepmc.org/articles/PMC6527112/
https://europepmc.org/articles/PMC6527112/