Výsledky vyhledávání - "Luca Ulianich"

Akademický článek

Metformin: A New Inhibitor of the Wnt Signaling Pathway in Cancer

Autor: Domenico Conza, Paola Mirra, Francesca Fiory, Luigi Insabato, Antonella Nicolò, Francesco Beguinot, Luca Ulianich

Publikováno v: Cells, Vol 12, Iss 17, p 2182 (2023)

The biguanide drug metformin is widely used in type 2 diabetes mellitus therapy, due to its ability to decrease serum glucose levels, mainly by reducing hepatic gluconeogenesis and glycogenolysis. A considerable number of studies have shown that metf

Externí odkaz: https://doaj.org/article/6ecf599bcba3436e8282ee0c4a96c615

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Akademický článek

The Pervasive Effects of ER Stress on a Typical Endocrine Cell: Dedifferentiation, Mesenchymal Shift and Antioxidant Response in the Thyrocyte

Autor: Luca Ulianich, Paola Mirra, Corrado Garbi, Gaetano Calì, Domenico Conza, Antonella Sonia Treglia, Alessandro Miraglia, Dario Punzi, Claudia Miele, Gregory Alexander Raciti, Francesco Beguinot, Eduardo Consiglio, Bruno Di Jeso

Publikováno v: Frontiers in Endocrinology, Vol 11 (2020)

The endoplasmic reticulum stress and the unfolded protein response are triggered following an imbalance between protein load and protein folding. Until recently, two possible outcomes of the unfolded protein response have been considered: life or dea

Externí odkaz: https://doaj.org/article/7cd84bf4c0da44c8a574057c161573b8

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Akademický článek

Metformin Dysregulates the Unfolded Protein Response and the WNT/β-Catenin Pathway in Endometrial Cancer Cells through an AMPK-Independent Mechanism

Autor: Domenico Conza, Paola Mirra, Gaetano Calì, Luigi Insabato, Francesca Fiory, Francesco Beguinot, Luca Ulianich

Publikováno v: Cells, Vol 10, Iss 5, p 1067 (2021)

Multiple lines of evidence suggest that metformin, an antidiabetic drug, exerts anti-tumorigenic effects in different types of cancer. Metformin has been reported to affect cancer cells’ metabolism and proliferation mainly through the activation of

Externí odkaz: https://doaj.org/article/98e0c931fb1d4054bbf9c7894c921590

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Akademický článek

Tyr Phosphatase-Mediated P-ERK Inhibition Suppresses Senescence in EIA + v-raf Transformed Cells, Which, Paradoxically, Are Apoptosis-Protected in a MEK-Dependent Manner

Autor: Stefania De Vitis, Antonella Sonia Treglia, Luca Ulianich, Stefano Turco, Giuseppe Terrazzano, Angela Lombardi, Claudia Miele, Corrado Garbi, Francesco Beguinot, Bruno Di Jeso

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 13, Iss 2, Pp 120-130 (2011)

Activation of the Ras-Raf-extracellular signal-regulated kinase (ERK) pathway causes not only proliferation and suppression of apoptosis but also the antioncogenic response of senescence. How these contrasting effects are reconciled to achieve cell t

Externí odkaz: https://doaj.org/article/f9b5ad1bc3ab4bd69d22657632883e1c

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Akademický článek

PED/PEA-15 inhibits hydrogen peroxide-induced apoptosis in Ins-1E pancreatic beta-cells via PLD-1.

Autor: Francesca Fiory, Luca Parrillo, Gregory Alexander Raciti, Federica Zatterale, Cecilia Nigro, Paola Mirra, Roberta Falco, Luca Ulianich, Bruno Di Jeso, Pietro Formisano, Claudia Miele, Francesco Beguinot

Publikováno v: PLoS ONE, Vol 9, Iss 12, p e113655 (2014)

The small scaffold protein PED/PEA-15 is involved in several different physiologic and pathologic processes, such as cell proliferation and survival, diabetes and cancer. PED/PEA-15 exerts an anti-apoptotic function due to its ability to interfere wi

Externí odkaz: https://doaj.org/article/79d74c91aefc4ba9b2b69f0bec1f68a1

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Akademický článek

Adenoviral gene transfer of PLD1-D4 enhances insulin sensitivity in mice by disrupting phospholipase D1 interaction with PED/PEA-15.

Autor: Angela Cassese, Gregory A Raciti, Francesca Fiory, Cecilia Nigro, Luca Ulianich, Ilenia Castanò, Vittoria D'Esposito, Daniela Terracciano, Lucio Pastore, Pietro Formisano, Francesco Beguinot, Claudia Miele

Publikováno v: PLoS ONE, Vol 8, Iss 4, p e60555 (2013)

Over-expression of phosphoprotein enriched in diabetes/phosphoprotein enriched in astrocytes (PED/PEA-15) causes insulin resistance by interacting with the D4 domain of phospholipase D1 (PLD1). Indeed, the disruption of this association restores insu

Externí odkaz: https://doaj.org/article/2b1b4ecaf1d24ddeaf20405c6094b3dc

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Metformin Dysregulates the Unfolded Protein Response and the WNT/β-Catenin Pathway in Endometrial Cancer Cells through an AMPK-Independent Mechanism

Autor: Francesca Fiory, Gaetano Calì, Paola Mirra, Luca Ulianich, Luigi Insabato, Domenico Conza, Francesco Beguinot

Publikováno v: Cells, Vol 10, Iss 1067, p 1067 (2021)
Cells
Volume 10
Issue 5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f335830fad195a4fa0b9b6a89402e50
https://www.mdpi.com/2073-4409/10/5/1067

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Diabetes and cognitive impairment: A role for glucotoxicity and dopaminergic dysfunction

Autor: Paola Mirra, Antonella Desiderio, Francesca Chiara Pignalosa, Cecilia Nigro, Pietro Formisano, Luca Ulianich, Claudia Miele, Raffaele Napoli, Francesca Fiory, Giuseppe Perruolo, Francesco Beguinot

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 12366, p 12366 (2021)

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by hyperglycemia, responsible for the onset of several long-term complications. Recent evidence suggests that cognitive dysfunction represents an emerging complication of DM, but th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::502227f1a1fdf06e5ba6a501c607d271
http://hdl.handle.net/11588/867673

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The Pervasive Effects of ER Stress on a Typical Endocrine Cell: Dedifferentiation, Mesenchymal Shift and Antioxidant Response in the Thyrocyte

Autor: Gaetano Calì, Gregory Alexander Raciti, Corrado Garbi, Claudia Miele, Paola Mirra, Eduardo Consiglio, Antonella Sonia Treglia, Domenico Conza, Alessandro Miraglia, Francesco Beguinot, Bruno Di Jeso, Dario Punzi, Luca Ulianich

Publikováno v: Frontiers in Endocrinology
Frontiers in Endocrinology, Vol 11 (2020)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9944642edace4610f4732fe6820dc976
http://europepmc.org/articles/PMC7680880

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Role of the HIF-1α/Nur77 axis in the regulation of the tyrosine hydroxylase expression by insulin in PC12 cells

Autor: Francesca Chiara Pignalosa, Cecilia Nigro, Luca Ulianich, Francesca Fiory, Pietro Formisano, Claudia Miele, Paola Mirra, Federica Zatterale, Francesco Beguinot, Nella Prevete

Publikováno v: Journal of cellular physiology
234 (2019): 11861–11870. doi:10.1002/jcp.27898
info:cnr-pdr/source/autori:Fiory, Francesca; Mirra, Paola; Nigro, Cecilia; Pignalosa, Francesca Chiara; Zatterale, Federica; Ulianich, Luca; Prevete, Nella; Formisano, Pietro; Beguinot, Francesco; Miele, Claudia/titolo:Role of the HIF-1?%2FNur77 axis in the regulation of the tyrosine hydroxylase expression by insulin in PC12 cells/doi:10.1002%2Fjcp.27898/rivista:Journal of cellular physiology (Print)/anno:2019/pagina_da:11861/pagina_a:11870/intervallo_pagine:11861–11870/volume:234

Tyrosine hydroxylase (TH), catalyzing the conversion of tyrosine into l-DOPA, is the rate-limiting enzyme in dopamine synthesis. Defects in insulin action contribute to alterations of TH expression and/or activity in the brain and insulin increases T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::431780674053769795db65865382ef88
https://pubmed.ncbi.nlm.nih.gov/30536670

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