Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Luca Torielli"'
Autor:
Sarah J. Backe, SarahBeth D. Votra, Matthew P. Stokes, Endre Sebestyén, Matteo Castelli, Luca Torielli, Giorgio Colombo, Mark R. Woodford, Mehdi Mollapour, Dimitra Bourboulia
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112539- (2023)
Summary: c-Src tyrosine kinase is a renowned key intracellular signaling molecule and a potential target for cancer therapy. Secreted c-Src is a recent observation, but how it contributes to extracellular phosphorylation remains elusive. Using a seri
Externí odkaz:
https://doaj.org/article/cd824932e9ec4ba28ad2022efbf0249e
Publikováno v:
Journal of chemical information and modeling. 63(1)
Protein-protein interactions (PPIs) have emerged in the past years as significant pharmacological targets in the development of new therapeutics due to their key roles in determining pathological pathways. Herein, we present fragments on energy surfa
Autor:
Alice Triveri, Carlos Sanchez-Martin, Luca Torielli, Stefano A. Serapian, Filippo Marchetti, Giovanni D'Acerno, Valentina Pirota, Matteo Castelli, Elisabetta Moroni, Mariarosaria Ferraro, Paolo Quadrelli, Andrea Rasola, Giorgio Colombo
Publikováno v:
Journal of molecular biology (Online) (2022). doi:10.1016/j.jmb.2022.167468
info:cnr-pdr/source/autori:Triveri A.; Sanchez-Martin C.; Torielli L.; Serapian S.A.; Marchetti F.; D'Acerno G.; Pirota V.; Castelli M.; Moroni E.; Ferraro M.; Quadrelli P.; Rasola A.; Colombo G./titolo:Protein Allostery and Ligand Design: Computational Design Meets Experiments to Discover Novel Chemical Probes/doi:10.1016%2Fj.jmb.2022.167468/rivista:Journal of molecular biology (Online)/anno:2022/pagina_da:/pagina_a:/intervallo_pagine:/volume
info:cnr-pdr/source/autori:Triveri A.; Sanchez-Martin C.; Torielli L.; Serapian S.A.; Marchetti F.; D'Acerno G.; Pirota V.; Castelli M.; Moroni E.; Ferraro M.; Quadrelli P.; Rasola A.; Colombo G./titolo:Protein Allostery and Ligand Design: Computational Design Meets Experiments to Discover Novel Chemical Probes/doi:10.1016%2Fj.jmb.2022.167468/rivista:Journal of molecular biology (Online)/anno:2022/pagina_da:/pagina_a:/intervallo_pagine:/volume
Herein we examine the determinants of the allosteric inhibition of the mitochondrial chaperone TRAP1 by a small molecule ligand. The knowledge generated is harnessed into the design of novel derivatives with interesting biological properties. TRAP1 i
Autor:
Luca Torielli, Alice Triveri, Filippo Marchetti, Matteo Castelli, Filippo Doria, Simona Collina, Stefano A. Serapian, Mauro Freccero, Giorgio Colombo, Valentina Pirota
Publikováno v:
RSC Med Chem
Computational chemistry has come of age in drug discovery. Indeed, most pharmaceutical development programs rely on computer-based data and results at some point. Herein, we discuss recent applications of advanced simulation techniques to difficult c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f660b262dc5f3f8b43e758d57426bb63
https://europepmc.org/articles/PMC8459323/
https://europepmc.org/articles/PMC8459323/