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Autor:
Anna J. Kiss-Szemán, Luca Takács, Zoltán Orgován, Pál Stráner, Imre Jákli, Gitta Schlosser, Simonas Masiulis, Veronika Harmat, Dóra K. Menyhárd, András Perczel
Publikováno v:
Chemical science. 13(48)
The structure of porcine AAP (pAAP) in a covalently bound complex with meropenem was determined by cryo-EM to 2.1 Å resolution, showing the mammalian serine-protease inhibited by a carbapenem antibiotic. AAP is a modulator of the ubiquitin-proteasom