Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Luca Settimo"'
Autor:
Ali H Alghamdi, Jane C Munday, Gustavo Daniel Campagnaro, Dominik Gurvic, Fredrik Svensson, Chinyere E Okpara, Arvind Kumar, Juan Quintana, Maria Esther Martin Abril, Patrik Milić, Laura Watson, Daniel Paape, Luca Settimo, Anna Dimitriou, Joanna Wielinska, Graeme Smart, Laura F Anderson, Christopher M Woodley, Siu Pui Ying Kelly, Hasan MS Ibrahim, Fabian Hulpia, Mohammed I Al-Salabi, Anthonius A Eze, Teresa Sprenger, Ibrahim A Teka, Simon Gudin, Simone Weyand, Mark Field, Christophe Dardonville, Richard R Tidwell, Mark Carrington, Paul O'Neill, David W Boykin, Ulrich Zachariae, Harry P De Koning
Publikováno v:
eLife, Vol 9 (2020)
Mutations in the Trypanosoma brucei aquaporin AQP2 are associated with resistance to pentamidine and melarsoprol. We show that TbAQP2 but not TbAQP3 was positively selected for increased pore size from a common ancestor aquaporin. We demonstrate that
Externí odkaz:
https://doaj.org/article/04cf21046dd94dac9faba5a20eaa5348
Autor:
Hideo Imamura, Tim Downing, Frederik Van den Broeck, Mandy J Sanders, Suman Rijal, Shyam Sundar, An Mannaert, Manu Vanaerschot, Maya Berg, Géraldine De Muylder, Franck Dumetz, Bart Cuypers, Ilse Maes, Malgorzata Domagalska, Saskia Decuypere, Keshav Rai, Surendra Uranw, Narayan Raj Bhattarai, Basudha Khanal, Vijay Kumar Prajapati, Smriti Sharma, Olivia Stark, Gabriele Schönian, Harry P De Koning, Luca Settimo, Benoit Vanhollebeke, Syamal Roy, Bart Ostyn, Marleen Boelaert, Louis Maes, Matthew Berriman, Jean-Claude Dujardin, James A Cotton
Publikováno v:
eLife, Vol 5 (2016)
Leishmania donovani causes visceral leishmaniasis (VL), the second most deadly vector-borne parasitic disease. A recent epidemic in the Indian subcontinent (ISC) caused up to 80% of global VL and over 30,000 deaths per year. Resistance against antimo
Externí odkaz:
https://doaj.org/article/3bf46ac4e98d432082a2d1782417edae
Autor:
Luca Settimo
Publikováno v:
History of European Ideas. :1-15
Autor:
Chau Mak, Luca Settimo, Guy Brenchley, Francoise Pierard, Andrew Miller, Dean Boyall, Philip N. Collier, Adam Tanner, Heather Twin, Clare M. Bolton, Peter Chiu, Juan-Miguel Jimenez, Shazia Keily, Elisabeth Doyle, Adam P. Curnock, Ronald Knegtel, Christopher John Davis
Publikováno v:
ACS Med Chem Lett
[Image: see text] PKCθ plays an important role in T cell biology and is a validated target for a number of disease states. A series of potent and selective PKCθ inhibitors were designed and synthesized starting from a HTS hit compound. Cell activit
Autor:
Anna Dimitriou, Daniel Paape, Christopher M Woodley, Ulrich Zachariae, Anthonius A. Eze, Simone Weyand, Ibrahim A. Teka, Ali H. Alghamdi, Richard R. Tidwell, Arvind Kumar, Jane C. Munday, Juan F. Quintana, Mark Carrington, Mohammed I. Al-Salabi, Paul M. O'Neill, Laura F Anderson, Maria Esther Martin Abril, Harry P. de Koning, Teresa Sprenger, Hasan M. S. Ibrahim, Fredrik Svensson, Simon Gudin, Fabian Hulpia, Patrik Milic, Chinyere E Okpara, Gustavo D. Campagnaro, Dominik Gurvic, Graeme Smart, David W. Boykin, Christophe Dardonville, Luca Settimo, Siu Pui Ying Kelly, Laura Watson, Joanna Wielinska, Mark C. Field
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa648917f3111794e8be1fa4dd747110
https://doi.org/10.7554/elife.56416.sa2
https://doi.org/10.7554/elife.56416.sa2
Autor:
Harry P. de Koning, Ibrahim A. Teka, Hasan M. S. Ibrahim, Christopher M Woodley, Simon Gudin, Patrik Mili, Arvind Kumar, Daniel Paape, Fredrik Svensson, Fabian Hulpia, Jane C. Munday, Mark Carrington, Mohammed I. Al-Salabi, Dominik Gurvic, Laura F Anderson, Christophe Dardonville, David W. Boykin, Chinyere E Okpara, Ali H. Alghamdi, Luca Settimo, Laura Watson, Maria Esther Martin Abril, Joanna Wielinska, Gustavo D. Campagnaro, Graeme Smart, Ulrich Zachariae, Anthonius A. Eze, Richard R. Tidwell, Anna Dimitriou, Siu Pui Ying Kelly, Paul M. O'Neill
Mutations in the Trypanosoma brucei aquaporin AQP2 are associated with resistance to pentamidine and melarsoprol. We show that TbAQP2 but not TbAQP3 was positively selected for increased pore size from a common ancestor aquaporin. We demonstrate that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e12a2c3019e9ca4c7a9a0aacc54e2b6b
Autor:
Paul M. O'Neill, Harry P. de Koning, Anna Dimitriou, Ulrich Zachariae, Joanna Wielinska, Arvind Kumar, Anthonius A. Eze, Mark C. Field, Chinyere E Okpara, Juan F. Quintana, Richard R. Tidwell, Simone Weyand, Luca Settimo, Siu Pui Ying Kelly, Christopher M Woodley, Dominik Gurvic, Ibrahim A. Teka, Mohammed I. Al-Salabi, Fredrik Svensson, Fabian Hulpia, Ali H. Alghamdi, Patrik Milic, Teresa Sprenger, Hasan M. S. Ibrahim, David W. Boykin, Laura Watson, Laura F Anderson, Daniel Paape, Mark Carrington, Maria Esther Martin Abril, Simon Gudin, Gustavo D. Campagnaro, Graeme Smart, Jane C. Munday, Christophe Dardonville
Publikováno v:
ELIFE
eLife
eLife, Vol 9 (2020)
Digital.CSIC. Repositorio Institucional del CSIC
instname
eLife
eLife, Vol 9 (2020)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Mutations in the Trypanosoma brucei aquaporin AQP2 are associated with resistance to pentamidine and melarsoprol. We show that TbAQP2 but not TbAQP3 was positively selected for increased pore size from a common ancestor aquaporin. We demonstrate that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22a8612e3af4438b62845ec7d02b257f
https://biblio.ugent.be/publication/8671473
https://biblio.ugent.be/publication/8671473
Autor:
Luca Settimo, David Taylor
Publikováno v:
Settimo, L & Taylor, D 2018, ' Evaluating the dose-dependent mechanism of action of trazodone by estimation of occupancies for different brain neurotransmitter targets ', Journal of Psychopharmacology, vol. 32, no. 1, pp. 96-104 . https://doi.org/10.1177/0269881117742101
Trazodone is a drug that was introduced in the clinic almost 40 years ago. It is licensed to treat depression, but it is also commonly used off-label to treat insomnia. A recent study shows that it could be promising in preventing neurodegeneration i
Autor:
Gabriele Schönian, Harry P. de Koning, Saskia Decuypere, Keshav Rai, Mandy Sanders, Shyam Sundar, Basudha Khanal, Jean-Claude Dujardin, Bart Cuypers, Géraldine De Muylder, An Mannaert, Smriti Sharma, Benoit Vanhollebeke, Bart Ostyn, Hideo Imamura, Ilse Maes, Maya Berg, Frederik Van den Broeck, Marleen Boelaert, Manu Vanaerschot, Narayan Raj Bhattarai, Syamal Roy, Vijay Kumar Prajapati, Suman Rijal, Olivia Stark, Malgorzata A. Domagalska, Surendra Uranw, James Cotton, Luca Settimo, Franck Dumetz, Matthew Berriman, Tim Downing, Louis Maes
Publikováno v:
eLife
eLife, Vol 5 (2016)
eLife, 5 (MARCH2016
eLife, Vol 5 (2016)
eLife, 5 (MARCH2016
Leishmania donovani causes visceral leishmaniasis (VL), the second most deadly vector- borne parasitic disease. A recent epidemic in the Indian subcontinent (ISC) caused up to 80% of global VL and over 30,000 deaths per year. Resistance against antim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c87589c838144b2c859857c3ce62e167
https://eprints.gla.ac.uk/118759/1/118759.pdf
https://eprints.gla.ac.uk/118759/1/118759.pdf
Author response: Evolutionary genomics of epidemic visceral leishmaniasis in the Indian subcontinent
Autor:
Syamal Roy, Manu Vanaerschot, Suman Rijal, Smriti Sharma, Gabriele Schönian, Jean-Claude Dujardin, Shyam Sundar, Louis Maes, Narayan Raj Bhattarai, Maya Berg, Benoit Vanhollebeke, Frederik Van den Broeck, Hideo Imamura, Harry P. de Koning, Bart Cuypers, Marleen Boelaert, Saskia Decuypere, Tim Downing, Keshav Rai, Malgorzata A. Domagalska, Mandy Sanders, Basudha Khanal, Ilse Maes, Surendra Uranw, James Cotton, Géraldine De Muylder, Bart Ostyn, An Mannaert, Matthew Berriman, Luca Settimo, Franck Dumetz, Vijay Kumar Prajapati, Olivia Stark
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21107eb746a85105e0af84b50e63c753
https://doi.org/10.7554/elife.12613.031
https://doi.org/10.7554/elife.12613.031