Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Luca Peruzzotti"'
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Externí odkaz:
https://doaj.org/article/19c7bf1cf8da474097e6c1ff19185501
Autor:
Regan Hamel, Luca Peruzzotti-Jametti, Katherine Ridley, Veronica Testa, Bryan Yu, David Rowitch, John C. Marioni, Stefano Pluchino
Publikováno v:
Heliyon, Vol 9, Iss 8, Pp e18339- (2023)
Traumatic spinal cord injuries (SCI) are a group of highly debilitating pathologies affecting thousands annually, and adversely affecting quality of life. Currently, no fully restorative therapies exist, and SCI still results in significant personal,
Externí odkaz:
https://doaj.org/article/f5c637943179487984dbc301440017d0
Autor:
Amin Mottahedin, Hiran A. Prag, Andreas Dannhorn, Richard Mair, Christina Schmidt, Ming Yang, Annabel Sorby-Adams, Jordan J. Lee, Nils Burger, Duvaraka Kulaveerasingam, Margaret M. Huang, Stefano Pluchino, Luca Peruzzotti-Jametti, Richard Goodwin, Christian Frezza, Michael P. Murphy, Thomas Krieg
Publikováno v:
Redox Biology, Vol 59, Iss , Pp 102600- (2023)
Current treatments for acute ischemic stroke aim to reinstate a normal perfusion in the ischemic territory but can also cause significant ischemia-reperfusion (IR) injury. Previous data in experimental models of stroke show that ischemia leads to the
Externí odkaz:
https://doaj.org/article/41b646b7b62b4c0d9fe37775e8348c63
Autor:
Lorna B. Jarvis, Daniel B. Rainbow, Valerie Coppard, Sarah K. Howlett, Zoya Georgieva, Jessica L. Davies, Harpreet Kaur Mullay, Joanna Hester, Tom Ashmore, Aletta Van Den Bosch, James T. Grist, Alasdair J. Coles, Hani S. Mousa, Stefano Pluchino, Krishnaa T. Mahbubani, Julian L. Griffin, Kourosh Saeb-Parsy, Fadi Issa, Luca Peruzzotti-Jametti, Linda S. Wicker, Joanne L. Jones
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Jarvis et al demonstrate that expanded human Tregs switch their metabolism to aerobic glycolysis and show enhanced suppressive function through hypoxia-inducible factor 1-alpha (HIF1A)-driven acquisition of CD73 expression, which along with CD39, ena
Externí odkaz:
https://doaj.org/article/45140660645e4b33867eb3d5efef93f6
Autor:
Paramesh Karandikar, Jakob V. E. Gerstl, Ari D. Kappel, Sae-Yeon Won, Daniel Dubinski, Monica Emili Garcia-Segura, Florian A. Gessler, Alfred Pokmeng See, Luca Peruzzotti-Jametti, Joshua D. Bernstock
Publikováno v:
Pharmaceuticals, Vol 16, Iss 5, p 673 (2023)
The small, ubiquitin-like modifier (SUMO) is a post-translational modifier with a profound influence on several key biological processes, including the mammalian stress response. Of particular interest are its neuroprotective effects, first recognize
Externí odkaz:
https://doaj.org/article/38d74909dd3e40e19ba7e33c0567e687
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Externí odkaz:
https://doaj.org/article/24ca91704d7e432d85745fdd8d34c01b
Autor:
Genevieve M. Sullivan, Andrew K. Knutsen, Luca Peruzzotti-Jametti, Alexandru Korotcov, Asamoah Bosomtwi, Bernard J. Dardzinski, Joshua D. Bernstock, Sandra Rizzi, Frank Edenhofer, Stefano Pluchino, Regina C. Armstrong
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-23 (2020)
Abstract Multiple Sclerosis (MS) causes neurologic disability due to inflammation, demyelination, and neurodegeneration. Immunosuppressive treatments can modify the disease course but do not effectively promote remyelination or prevent long term neur
Externí odkaz:
https://doaj.org/article/599cef53dc3a4e46b2b4e66edd145f9c
Autor:
Kimberley Allen-Philbey, Stefania De Trane, Zhifeng Mao, Cesar Álvarez-González, Joela Mathews, Amy MacDougall, Andrea Stennett, Xia Zhou, Ozlem Yildiz, Ashok Adams, Lucia Bianchi, Camilla Blain, Christine Chapman, Karen Chung, Cris S Constantinescu, Catherine Dalton, Rachel A Farrell, Leonora Fisniku, Helen Ford, Bruno Gran, Jeremy Hobart, Zhaleh Khaleeli, Miriam Mattoscio, Sue Pavitt, Owen Pearson, Luca Peruzzotti-Jametti, Antonio Scalfari, Basil Sharrack, Eli Silber, Emma C Tallantyre, Stewart Webb, Benjamin P Turner, Monica Marta, Sharmilee Gnanapavan, Gunnar Juliusson, Gavin Giovannoni, David Baker, Klaus Schmierer
Publikováno v:
Therapeutic Advances in Neurological Disorders, Vol 14 (2021)
Objective: To report on safety and effectiveness of subcutaneous cladribine (Litak ® ) in multiple sclerosis (MS) patients. Methods: Litak ® was offered to MS-patients irrespective of disease course. Litak ® 10 mg was administered for 3–4 days d
Externí odkaz:
https://doaj.org/article/bfd4d711187c4be1bbc0bfb3a0440750
Autor:
Jayden A. Smith, Alexandra M. Nicaise, Rosana-Bristena Ionescu, Regan Hamel, Luca Peruzzotti-Jametti, Stefano Pluchino
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by demyelination and axonal degeneration. MS patients typically present with a relapsing-remitting (RR) disease course, manifesting as sporadic atta
Externí odkaz:
https://doaj.org/article/39af18a3116e41dba5bf093ebb5b7796
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Compelling evidence exists that patients with chronic neurological conditions, which includes progressive multiple sclerosis, display pathological changes in neural metabolism and mitochondrial function. However, it is unknown if a similar degree of
Externí odkaz:
https://doaj.org/article/54905c84c0eb43578c5e305bfa73221e