Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Luca Pellegrinet"'
Autor:
Nicole M. Sodir, Luca Pellegrinet, Roderik M. Kortlever, Tania Campos, Yong-Won Kwon, Shinseog Kim, Daniel Garcia, Alessandra Perfetto, Panayiotis Anastasiou, Lamorna Brown Swigart, Mark J. Arends, Trevor D. Littlewood, Gerard I. Evan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Happloinsufficiency of Myc delays onset of cancers in mice. Here, the authors generated a mouse model of reversible cMyc hypomorphism and show that metronomic reduction of c-Myc in adult mice confers protection against cancers without side effects an
Externí odkaz:
https://doaj.org/article/f2edbfdb52b64070a843f6b7ca3e272f
Autor:
Gerard I. Evan, Trevor D. Littlewood, Mark J. Arends, Laura Soucek, Lamorna Brown Swigart, Panayiotis Anastasiou, Steven Kupczak, Luca Pellegrinet, Tania Campos, Valentin J.A. Barthet, Roderik M. Kortlever, Nicole M. Sodir
MycERT2 expression in pancreata of Mpdx1 and Mp48 mice is at a level comparable to that of endogenous c-Myc in proliferating neonatal pancreas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1369634b3e6aac2bd088a54e80c2cf07
https://doi.org/10.1158/2159-8290.22535044.v1
https://doi.org/10.1158/2159-8290.22535044.v1
Autor:
Gerard I. Evan, Trevor D. Littlewood, Mark J. Arends, Laura Soucek, Lamorna Brown Swigart, Panayiotis Anastasiou, Steven Kupczak, Luca Pellegrinet, Tania Campos, Valentin J.A. Barthet, Roderik M. Kortlever, Nicole M. Sodir
The signature features of pancreatic ductal adenocarcinoma (PDAC) are its fibroinflammatory stroma, poor immune activity, and dismal prognosis. We show that acute activation of Myc in indolent pancreatic intraepithelial neoplasm (PanIN) epithelial ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fb096b64ace5de33f588472ef8dc731
https://doi.org/10.1158/2159-8290.c.6547741.v1
https://doi.org/10.1158/2159-8290.c.6547741.v1
Autor:
Gerard I. Evan, Trevor D. Littlewood, Mark J. Arends, Laura Soucek, Lamorna Brown Swigart, Panayiotis Anastasiou, Steven Kupczak, Luca Pellegrinet, Tania Campos, Valentin J.A. Barthet, Roderik M. Kortlever, Nicole M. Sodir
Comparison of Myc-induced stromal phenotypes in KRasG12D-driven PanIN versus KRasG12D-driven lung adenoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a2fea709b5d1ce5d40e1e10d17aaebe
https://doi.org/10.1158/2159-8290.22535011
https://doi.org/10.1158/2159-8290.22535011
Autor:
Bruno Amati, Gerard I. Evan, Trevor D. Littlewood, Enrico Radaelli, Alessandro Verrecchia, Micol Ravà, Thelma Capra, Luca Rotta, Salvatore Bianchi, Camilla Recordati, Mirko Doni, Paola Nicoli, Valerio Bianchi, Luca Pellegrinet, Paola Pellanda, Theresia R. Kress
MycVD induces proliferation to a similar extend as MycWT but is impaired in cellular transformation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88a5dc71a4a60e365841b123aad69483
https://doi.org/10.1158/0008-5472.22411665
https://doi.org/10.1158/0008-5472.22411665
Autor:
Bruno Amati, Gerard I. Evan, Trevor D. Littlewood, Enrico Radaelli, Alessandro Verrecchia, Micol Ravà, Thelma Capra, Luca Rotta, Salvatore Bianchi, Camilla Recordati, Mirko Doni, Paola Nicoli, Valerio Bianchi, Luca Pellegrinet, Paola Pellanda, Theresia R. Kress
Description of additional methods and procedures used in the study. Also includes Supplementary References.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38feb1aa6ffa33436fa76ac071ae6bf8
https://doi.org/10.1158/0008-5472.22411650
https://doi.org/10.1158/0008-5472.22411650
Autor:
Bruno Amati, Gerard I. Evan, Trevor D. Littlewood, Enrico Radaelli, Alessandro Verrecchia, Micol Ravà, Thelma Capra, Luca Rotta, Salvatore Bianchi, Camilla Recordati, Mirko Doni, Paola Nicoli, Valerio Bianchi, Luca Pellegrinet, Paola Pellanda, Theresia R. Kress
MycVD-sensitive genes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0928aa0812ebd595332856a69dd4d82d
https://doi.org/10.1158/0008-5472.22411641.v1
https://doi.org/10.1158/0008-5472.22411641.v1
Autor:
Bruno Amati, Gerard I. Evan, Trevor D. Littlewood, Enrico Radaelli, Alessandro Verrecchia, Micol Ravà, Thelma Capra, Luca Rotta, Salvatore Bianchi, Camilla Recordati, Mirko Doni, Paola Nicoli, Valerio Bianchi, Luca Pellegrinet, Paola Pellanda, Theresia R. Kress
Legend for Supplementary Figures S1-S6 and Supplementary Table S1-S3.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09ff26cb043780fc143cdd341ecb841f
https://doi.org/10.1158/0008-5472.22411653
https://doi.org/10.1158/0008-5472.22411653
Data from Identification of MYC-Dependent Transcriptional Programs in Oncogene-Addicted Liver Tumors
Autor:
Bruno Amati, Gerard I. Evan, Trevor D. Littlewood, Enrico Radaelli, Alessandro Verrecchia, Micol Ravà, Thelma Capra, Luca Rotta, Salvatore Bianchi, Camilla Recordati, Mirko Doni, Paola Nicoli, Valerio Bianchi, Luca Pellegrinet, Paola Pellanda, Theresia R. Kress
Tumors driven by activation of the transcription factor MYC generally show oncogene addiction. However, the gene expression programs that depend upon sustained MYC activity remain unknown. In this study, we employed a mouse model of liver carcinoma d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f64b4c3bfd8c50d38726216ba301076
https://doi.org/10.1158/0008-5472.c.6508269.v1
https://doi.org/10.1158/0008-5472.c.6508269.v1
Autor:
Jack Leslie, Michael Allison, Fiona Oakley, Gabriele Mocciaro, Matthew Hoare, Luca Pellegrinet, Julian L. Griffin, Evelina Charidemou, Quentin M. Anstee, Michele Vacca, Antonio Vidal-Puig, Davide Chiarugi, Gerard I. Evan, Emma Scott, Zoe Hall
Publikováno v:
Hepatology
Background and aims: Hepatocytes undergo profound metabolic rewiring when primed to proliferate during compensatory regeneration and in hepatocellular carcinoma (HCC). However, the metabolic control of these processes is not fully understood. In orde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bb36773392f0162bc9ae6b488356eaf
https://doi.org/10.1002/hep.31391
https://doi.org/10.1002/hep.31391