Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Luca Palazzo"'
Autor:
Francesco Morra, Francesco Merolla, Giovanna Damia, Francesca Ricci, Silvia Varricchio, Gennaro Ilardi, Laura Arenare, Daniela Califano, Virginia Napolitano, Robert Fruscio, Rosa Marina Melillo, Luca Palazzo, Angela Celetti
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-21 (2022)
Abstract Background Treatment with PARP inhibitors (PARPi) is primarily effective against high-grade serous ovarian cancers (HGSOC) with BRCA1/2 mutations or other deficiencies in homologous recombination (HR) repair mechanisms. However, resistance t
Externí odkaz:
https://doaj.org/article/adbdda7216ee4ee5a177948cec916279
Publikováno v:
Pathogens, Vol 12, Iss 2, p 240 (2023)
The chemical modification of cellular macromolecules by the transfer of ADP-ribose unit(s), known as ADP-ribosylation, is an ancient homeostatic and stress response control system. Highly conserved across the evolution, ADP-ribosyltransferases and AD
Externí odkaz:
https://doaj.org/article/ac068515e9ad45e2be08f2c99b28b39f
Publikováno v:
Open Biology, Vol 9, Iss 4 (2019)
ADP-ribosylation (ADPr) is a reversible post-translational modification of proteins, which controls major cellular and biological processes, including DNA damage repair, cell proliferation and differentiation, metabolism, stress and immune responses.
Externí odkaz:
https://doaj.org/article/8e149182a43b45d58a6444e803ef7861
Mono(ADP-ribosyl)ation Enzymes and NAD+ Metabolism: A Focus on Diseases and Therapeutic Perspectives
Publikováno v:
Cells, Vol 10, Iss 1, p 128 (2021)
Mono(ADP-ribose) transferases and mono(ADP-ribosyl)ating sirtuins use NAD+ to perform the mono(ADP-ribosyl)ation, a simple form of post-translational modification of proteins and, in some cases, of nucleic acids. The availability of NAD+ is a limitin
Externí odkaz:
https://doaj.org/article/b08d5ec9426342f89864e6970b9a3866
Publikováno v:
eLife, Vol 7 (2018)
Poly(ADP-ribose) polymerases (PARPs) are a family of enzymes that synthesise ADP-ribosylation (ADPr), a reversible modification of proteins that regulates many different cellular processes. Several mammalian PARPs are known to regulate the DNA damage
Externí odkaz:
https://doaj.org/article/1585b06cceda46c0884721dc94e68fa4
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
MacroD1 is a macrodomain containing protein that has mono-ADP-ribose hydrolase enzymatic activity toward several ADP-ribose adducts. Dysregulation of MacroD1 expression has been shown to be associated with the pathogenesis of several forms of cancer.
Externí odkaz:
https://doaj.org/article/e0e1309fd0fb41ab9c4c208cc98ed83e
Publikováno v:
eLife, Vol 6 (2017)
ADP-ribosylation (ADPr) is a posttranslational modification (PTM) of proteins that controls many cellular processes, including DNA repair, transcription, chromatin regulation and mitosis. A number of proteins catalyse the transfer and hydrolysis of A
Externí odkaz:
https://doaj.org/article/4589c1ff47014ade8a4e46ecb6c89bdb
Publikováno v:
PLoS ONE, Vol 2, Iss 2, p e247 (2007)
M-phase Promoting Factor (MPF; the cyclin B-cdk 1 complex) is activated at M-phase onset by removal of inhibitory phosphorylation of cdk1 at thr-14 and tyr-15. At M-phase exit, MPF is destroyed by ubiquitin-dependent cyclin proteolysis. Thus, control
Externí odkaz:
https://doaj.org/article/19d0611cefc4446c98f7d6fc0d7e6127
Autor:
Yao Wei, Luca Palazzolo, Omar Ben Mariem, Davide Bianchi, Tommaso Laurenzi, Uliano Guerrini, Ivano Eberini
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 3090-3103 (2024)
Cytochrome P450 (CYP450) enzymes comprise a highly diverse superfamily of heme-thiolate proteins that responsible for catalyzing over 90 % of enzymatic reactions associated with xenobiotic metabolism in humans. Accurately predicting whether chemicals
Externí odkaz:
https://doaj.org/article/42f7b7f4a26f4d969ea93f284bf78cab
Publikováno v:
Genes & development 34 (2020): 263–284. doi:10.1101/gad.334631.119
info:cnr-pdr/source/autori:Rack, Johannes Gregor Matthias; Palazzo, Luca; Ahel, Ivan/titolo:(ADP-ribosyl)hydrolases: structure, function, and biology/doi:10.1101%2Fgad.334631.119/rivista:Genes & development/anno:2020/pagina_da:263/pagina_a:284/intervallo_pagine:263–284/volume:34
info:cnr-pdr/source/autori:Rack, Johannes Gregor Matthias; Palazzo, Luca; Ahel, Ivan/titolo:(ADP-ribosyl)hydrolases: structure, function, and biology/doi:10.1101%2Fgad.334631.119/rivista:Genes & development/anno:2020/pagina_da:263/pagina_a:284/intervallo_pagine:263–284/volume:34
ADP-ribosylation is an intricate and versatile posttranslational modification involved in the regulation of a vast variety of cellular processes in all kingdoms of life. Its complexity derives from the varied range of different chemical linkages, inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa13013ad86ad7935d92334b75792704
https://doi.org/10.1101/gad.334631.119
https://doi.org/10.1101/gad.334631.119
