Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Luca Murru"'
Autor:
Elisa Focchi, Clara Cambria, Lara Pizzamiglio, Luca Murru, Silvia Pelucchi, Laura D’Andrea, Silvano Piazza, Lorenzo Mattioni, Maria Passafaro, Elena Marcello, Giovanni Provenzano, Flavia Antonucci
Publikováno v:
Cell Death and Disease, Vol 13, Iss 7, Pp 1-13 (2022)
Abstract Interest in the function of ataxia-telangiectasia-mutated protein (ATM) is extensively growing as evidenced by preclinical studies that continuously link ATM with new intracellular pathways. Here, we exploited Atm +/− and Atm −/− mice
Externí odkaz:
https://doaj.org/article/034bec23720144fca3240bc13c6dcaa0
Autor:
Lara Pizzamiglio, Elisa Focchi, Clara Cambria, Luisa Ponzoni, Silvia Ferrara, Francesco Bifari, Genni Desiato, Nicoletta Landsberger, Luca Murru, Maria Passafaro, Mariaelvina Sala, Michela Matteoli, Elisabetta Menna, Flavia Antonucci
Publikováno v:
JCI Insight, Vol 6, Iss 3 (2021)
Impairment of the GABAergic system has been reported in epilepsy, autism, attention deficit hyperactivity disorder, and schizophrenia. We recently demonstrated that ataxia telangiectasia mutated (ATM) directly shapes the development of the GABAergic
Externí odkaz:
https://doaj.org/article/b9f62349857e4ce28e30a250364f0897
Autor:
Luca Murru, Luisa Ponzoni, Anna Longatti, Sara Mazzoleni, Giorgia Giansante, Silvia Bassani, Mariaelvina Sala, Maria Passafaro
Publikováno v:
Neurobiology of Disease, Vol 148, Iss , Pp 105189- (2021)
Mutations in the TM4SF2 gene, which encodes TSPAN7, cause a severe form of intellectual disability (ID) often comorbid with autism spectrum disorder (ASD). Recently, we found that TM4SF2 loss in mice affects cognition. Here, we report that Tm4sf2−/
Externí odkaz:
https://doaj.org/article/b256e8940cbf477a9c99575d2b083f48
Autor:
Valentina Zamboni, Maria Armentano, Gaia Berto, Elisa Ciraolo, Alessandra Ghigo, Donatella Garzotto, Alessandro Umbach, Ferdinando DiCunto, Elena Parmigiani, Marina Boido, Alessandro Vercelli, Nadia El-Assawy, Alessandro Mauro, Lorenzo Priano, Luisa Ponzoni, Luca Murru, Maria Passafaro, Emilio Hirsch, Giorgio R. Merlo
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)
Abstract The small-GTPase Rac1 is a key molecular regulator linking extracellular signals to actin cytoskeleton dynamics. Loss-of-function mutations in RAC1 and other genes of the Rac signaling pathway have been implicated in the pathogenesis of Inte
Externí odkaz:
https://doaj.org/article/638ec94828f043b0b3fe8bf5f8131542
Autor:
Jonathan Zapata, Edoardo Moretto, Saad Hannan, Luca Murru, Anna Longatti, Davide Mazza, Lorena Benedetti, Matteo Fossati, Christopher Heise, Luisa Ponzoni, Pamela Valnegri, Daniela Braida, Mariaelvina Sala, Maura Francolini, Jeffrey Hildebrand, Vera Kalscheuer, Francesca Fanelli, Carlo Sala, Bernhard Bettler, Silvia Bassani, Trevor G. Smart, Maria Passafaro
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Mutations in the gene encoding Shrm4 are associated with epilepsy and intellectual disability. The authors show that Shrm4 interacts with GABABreceptors and regulates tonic inhibition in the hippocampus, and knockdown of Shrm4 in rats leads to anxiet
Externí odkaz:
https://doaj.org/article/4624279b47d64159ad6a26ab96fc80e0
Autor:
Edoardo Moretto, Anna Longatti, Luca Murru, Ingrid Chamma, Alessandro Sessa, Jonathan Zapata, Eric Hosy, Matthieu Sainlos, Julien Saint-Pol, Eric Rubinstein, Daniel Choquet, Vania Broccoli, Giampietro Schiavo, Olivier Thoumine, Maria Passafaro
Publikováno v:
Cell Reports, Vol 29, Iss 5, Pp 1130-1146.e8 (2019)
Summary: Tetraspanins are a class of evolutionarily conserved transmembrane proteins with 33 members identified in mammals that have the ability to organize specific membrane domains, named tetraspanin-enriched microdomains (TEMs). Despite the relati
Externí odkaz:
https://doaj.org/article/cdbe2940244f484a965d4f1873afae75
Autor:
Diana Alaverdian, Anna Margherita Corradi, Bruno Sterlini, Fabio Benfenati, Luca Murru, Maria Passafaro, Jlenia Brunetti, Ilaria Meloni, Francesca Mari, Alessandra Renieri, Elisa Frullanti
Publikováno v:
Epileptic Disorders.
Autor:
Giorgia Giansante, Sara Mazzoleni, Antonio G. Zippo, Luisa Ponzoni, Anna Ghilardi, Greta Maiellano, Elly Lewerissa, Eline van Hugte, Nael Nadif Kasri, Maura Francolini, Mariaelvina Sala, Luca Murru, Silvia Bassani, Maria Passafaro
Mutations in PCDH19 gene, which encodes protocadherin-19 (PCDH19), cause Developmental and Epileptic Encephalopathy 9 (DEE9). Heterogeneous loss of PCDH19 expression in neurons is considered a key determinant of the disorder; however, how PCDH19 mosa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38a1ed5e212aa48375251b7cb6511c8e
https://hdl.handle.net/2434/962616
https://hdl.handle.net/2434/962616
Autor:
Giorgia Giansante, Anna Longatti, Mariaelvina Sala, Maria Passafaro, Luca Murru, Maria Nicol Colombo, Edoardo Moretto, Luisa Ponzoni, N. Lattuada, Maura Francolini
Publikováno v:
Molecular Neurobiology
Rho GTPases are a class of G-proteins involved in several aspects of cellular biology, including the regulation of actin cytoskeleton. The most studied members of this family are RHOA and RAC1 that act in concert to regulate actin dynamics. Recently,
Autor:
Erika Pizzi, Michele Mazzanti, Silvia Pelucchi, Sara Mazzoleni, Giulia Maia Serratto, Silvia Bassani, Elena Marcello, Maria Passafaro, Luca Murru
Publikováno v:
Molecular Neurobiology. 57:5336-5351
PCDH19 encodes for protocadherin-19 (PCDH19), a cell-adhesion molecule of the cadherin superfamily preferentially expressed in the brain. PCDH19 mutations cause a neurodevelopmental syndrome named epileptic encephalopathy, early infantile, 9 (EIEE9)