Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Luca Moccia"'
Autor:
Olivier Bezençon, Thomas Pfeifer, Johannes Mosbacher, Isabelle Reymond, Eric A. Ertel, Ruben de Kanter, Bruno Capeleto, Elvire Fournier, Markus Rey, Luca Moccia, Michael Toeroek-Schafroth, René Roscher, Richard Moon, John Gatfield, Melanie Kessler, Romain Siegrist, Bibia Heidmann, Davide Pozzi, Simon Stamm, Luboš Remeň, Sylvia Richard, Lloyd Simons, Rick Gaston, Dennis Downing, Corinna Grisostomi, Catherine Roch, Benno Schindelholz
Publikováno v:
CHIMIA, Vol 71, Iss 10 (2017)
We describe the discovery and optimization of new, brain-penetrant T-type calcium channel blockers. We present optimized compounds with excellent efficacy in a rodent model of generalized absence-like epilepsy. Along the fine optimization of a chemic
Externí odkaz:
https://doaj.org/article/77760779eafd425e854518b6109e1f36
Autor:
Ruben de Kanter, René Roscher, Rick D Gaston, Benno Schindelholz, John Gatfield, Catherine Roch, Olivier Bezencon, Eric A. Ertel, Johannes Mosbacher, Bruno Capeleto, Luboš Remeň, Davide Pozzi, Lloyd Simons, Thomas Pfeifer, Bibia Heidmann, Isabelle Reymond, Melanie Kessler, Corinna Grisostomi, Dennis Michael Downing, Simon Stamm, Richard Moon, Sylvia Richard, Luca Moccia, Romain Siegrist, Michael Toeroek-Schafroth, Elvire Fournier, Markus Rey
Publikováno v:
CHIMIA, Vol 71, Iss 10 (2017)
We describe the discovery and optimization of new, brain-penetrant T-type calcium channel blockers. We present optimized compounds with excellent efficacy in a rodent model of generalized absence-like epilepsy. Along the fine optimization of a chemic
Autor:
Steven M, Bromidge, Roberto, Arban, Barbara, Bertani, Silvia, Bison, Manuela, Borriello, Paolo, Cavanni, Giovanna, Dal Forno, Romano, Di-Fabio, Daniele, Donati, Stefano, Fontana, Massimo, Gianotti, Laurie J, Gordon, Enrica, Granci, Colin P, Leslie, Luca, Moccia, Alessandra, Pasquarello, Ilaria, Sartori, Anna, Sava, Jeannette M, Watson, Angela, Worby, Laura, Zonzini, Valeria, Zucchelli
Publikováno v:
Journal of medicinal chemistry. 53(15)
Bioisoteric replacement of the metabolically labile N-methyl amide group of a series of benzoxazinones with small heterocyclic rings has led to novel series of fused tricyclic benzoxazines which are potent 5-HT(1A/B/D) receptor antagonists with and w