Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Luca Mignani"'
Impact of an irreversible β-galactosylceramidase inhibitor on the lipid profile of zebrafish embryos
Autor:
Jessica Guerra, Mirella Belleri, Giulia Paiardi, Chiara Tobia, Davide Capoferri, Marzia Corli, Elisa Scalvini, Marco Ghirimoldi, Marcello Manfredi, Rebecca C. Wade, Marco Presta, Luca Mignani
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 1397-1407 (2024)
Krabbe disease is a sphingolipidosis characterized by the genetic deficiency of the acid hydrolase β-galactosylceramidase (GALC). Most of the studies concerning the biological role of GALC performed on Krabbe patients and Galc-deficient twitcher mic
Externí odkaz:
https://doaj.org/article/c98712cfb14b4da3a4a44f64229c80dd
Autor:
Daniela Zizioli, Eugenia Quiros-Roldan, Sara Ferretti, Luca Mignani, Giorgio Tiecco, Eugenio Monti, Francesco Castelli, Isabella Zanella
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 9, p 4640 (2024)
Dolutegravir (DTG) is one of the most prescribed antiretroviral drugs for treating people with HIV infection, including women of child-bearing potential or pregnant. Nonetheless, neuropsychiatric symptoms are frequently reported. Early reports sugges
Externí odkaz:
https://doaj.org/article/8a9ed475837a4b489fa7979a90c4dae8
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 5, p 3062 (2024)
Mitochondrial plasticity, marked by a dynamism between glycolysis and oxidative phosphorylation due to adaptation to genetic and microenvironmental alterations, represents a characteristic feature of melanoma progression. Sphingolipids play a signifi
Externí odkaz:
https://doaj.org/article/5700f762d49e4b8ba600c673e44aa661
Autor:
Marion Rosello, Malo Serafini, Luca Mignani, Dario Finazzi, Carine Giovannangeli, Marina C. Mione, Jean-Paul Concordet, Filippo Del Bene
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Abstract Base Editors are emerging as an innovative technology to introduce point mutations in complex genomes. So far, the requirement of an NGG Protospacer Adjacent Motif (PAM) at a suitable position often limits the base editing possibility to mod
Externí odkaz:
https://doaj.org/article/f45c31dac8534e71af2843d61f08997b
Autor:
Daniela Zizioli, Sara Ferretti, Giorgio Tiecco, Luca Mignani, Eugenio Monti, Francesco Castelli, Eugenia Quiros-Roldan, Isabella Zanella
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 14, p 11664 (2023)
In the past, one of the most widely used non-nucleoside reverse transcriptase inhibitors (NNRTI) in first-line antiretroviral therapy (ART) of HIV infection was efavirenz (EFV), which is already used as a cost-effective treatment in developing countr
Externí odkaz:
https://doaj.org/article/fadfee0cc8134f92a2d26414d8d49c36
Autor:
Davide Capoferri, Paola Chiodelli, Marzia Corli, Mirella Belleri, Elisa Scalvini, Luca Mignani, Jessica Guerra, Elisabetta Grillo, Veronica De Giorgis, Marcello Manfredi, Marco Presta
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 10555 (2023)
β-Galactosylceramidase (GALC) is a lysosomal enzyme involved in sphingolipid metabolism by removing β-galactosyl moieties from β-galactosylceramide and β-galactosylsphingosine. Previous observations have shown that GALC may exert pro-oncogenic fu
Externí odkaz:
https://doaj.org/article/cea438e1caca4f03bd2fb2095464f450
Autor:
Luca Mignani, Nicola Facchinello, Marco Varinelli, Elena Massardi, Natascia Tiso, Cosetta Ravelli, Stefania Mitola, Peter Schu, Eugenio Monti, Dario Finazzi, Giuseppe Borsani, Daniela Zizioli
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 7108 (2023)
In vertebrates, two homologous heterotetrameric AP1 complexes regulate the intracellular protein sorting via vesicles. AP-1 complexes are ubiquitously expressed and are composed of four different subunits: γ, β1, μ1 and σ1. Two different complexe
Externí odkaz:
https://doaj.org/article/a4d583b476f24210bdd091760345bb72
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4747 (2023)
Sphingolipidoses are inborn errors of metabolism due to the pathogenic mutation of genes that encode for lysosomal enzymes, transporters, or enzyme cofactors that participate in the sphingolipid catabolism. They represent a subgroup of lysosomal stor
Externí odkaz:
https://doaj.org/article/445b10932895421fa5fb2ea29ddec687
Autor:
Daniela Zizioli, Isabella Zanella, Luca Mignani, Melania Degli Antoni, Francesco Castelli, Eugenia Quiros-Roldan
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 1994 (2023)
As most new medications, Cabotegravir (CAB) was recently approved as an antiretroviral treatment of HIV infection without in-depth safety information on in utero exposure. Although no developmental toxicity in rats and rabbits was reported, recent st
Externí odkaz:
https://doaj.org/article/06848907b12d4284b5db90fcd9193f19
Autor:
Luca Mignani, Daniela Zizioli, Deepak Khatri, Nicola Facchinello, Marco Schiavone, Giuseppe De Palma, Dario Finazzi
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 12914 (2022)
Coenzyme A (CoA) is an essential cofactor in all living organisms, being involved in a large number of chemical reactions. Sequence variations in pantothenate kinase 2 (PANK2), the first enzyme of CoA biosynthesis, are found in patients affected by P
Externí odkaz:
https://doaj.org/article/df61926b300849b8925ab21f00d9f6a1