Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Luca Micci"'
Autor:
Justin Harper, Nicolas Huot, Luca Micci, Gregory Tharp, Colin King, Philippe Rascle, Neeta Shenvi, Hong Wang, Cristin Galardi, Amit A. Upadhyay, Francois Villinger, Jeffrey Lifson, Guido Silvestri, Kirk Easley, Beatrice Jacquelin, Steven Bosinger, Michaela Müller-Trutwin, Mirko Paiardini
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Infection of African green monkeys with SIV is associated with reduced pathogenicity. Here the authors explore the requirement of differentiated NK cell populations in a pathogenic Rhesus macaque model of SIV infection and show administration of IL-2
Externí odkaz:
https://doaj.org/article/c2ab2bb398384c18b3ef628de01ccc2b
Autor:
Justin Harper, Susan P. Ribeiro, Chi Ngai Chan, Malika Aid, Claire Deleage, Luca Micci, Maria Pino, Barbara Cervasi, Gopalan Raghunathan, Eric Rimmer, Gulesi Ayanoglu, Guoxin Wu, Neeta Shenvi, Richard J.O. Barnard, Gregory Q. Del Prete, Kathleen Busman-Sahay, Guido Silvestri, Deanna A. Kulpa, Steven E. Bosinger, Kirk A. Easley, Bonnie J. Howell, Dan Gorman, Daria J. Hazuda, Jacob D. Estes, Rafick-Pierre Sekaly, Mirko Paiardini
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 8 (2022)
Interleukin-10 (IL-10) is an immunosuppressive cytokine that signals through STAT3 to regulate T follicular helper (Tfh) cell differentiation and germinal center formation. In SIV-infected macaques, levels of IL-10 in plasma and lymph nodes (LNs) wer
Externí odkaz:
https://doaj.org/article/3c551d2d1a814a3d84819bbd3a685652
Autor:
Maria Pino, Susan Pereira Ribeiro, Amélie Pagliuzza, Khader Ghneim, Anum Khan, Emily Ryan, Justin L Harper, Colin T King, Sarah Welbourn, Luca Micci, Sol Aldrete, Keith A Delman, Theron Stuart, Michael Lowe, Jason M Brenchley, Cynthia A Derdeyn, Kirk Easley, Rafick P Sekaly, Nicolas Chomont, Mirko Paiardini, Vincent C Marconi
Publikováno v:
PLoS Pathogens, Vol 17, Iss 8, p e1009825 (2021)
Clinical outcomes are inferior for individuals with HIV having suboptimal CD4 T-cell recovery during antiretroviral therapy (ART). We investigated if the levels of infection and the response to homeostatic cytokines of CD4 T-cell subsets contributed
Externí odkaz:
https://doaj.org/article/067e37f438b34fd7827433be61b176ba
Autor:
Graham Thomas, Luca Micci, Wenjing Yang, Joseph Katakowski, Cecilia Oderup, Purnima Sundar, Xiao Wang, Kenneth G. Geles, Shobha Potluri, Shahram Salek-Ardakani
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Toll-like receptor (TLR) agonists have received considerable attention as therapeutic targets for cancer immunotherapy owing to their ability to convert immunosuppressive tumor microenvironments towards a more T-cell inflamed phenotype. However, TLRs
Externí odkaz:
https://doaj.org/article/f1403811aba84fdf968fa1fa9f033bac
Autor:
Maria Pino, Sara Paganini, Claire Deleage, Kartika Padhan, Justin L Harper, Colin T King, Luca Micci, Barbara Cervasi, Joseph C Mudd, Kiran P Gill, Sherrie M Jean, Kirk Easley, Guido Silvestri, Jacob D Estes, Constantinos Petrovas, Michael M Lederman, Mirko Paiardini
Publikováno v:
PLoS Pathogens, Vol 15, Iss 10, p e1008081 (2019)
Lymph nodes (LN) and their resident T follicular helper CD4+ T cells (Tfh) are a critical site for HIV replication and persistence. Therefore, optimizing antiviral activity in lymphoid tissues will be needed to reduce or eliminate the HIV reservoir.
Externí odkaz:
https://doaj.org/article/317b112ab6a540088ba22b5560bb1102
Publikováno v:
Journal of Virus Eradication, Vol 1, Iss 1, Pp 17-22 (2015)
Current HIV antiretroviral therapy (ART) successfully inhibits viral replication in the majority of HIV-infected individuals. However, ART is not curative and lifelong adherence is required. Despite the undisputed benefit of ART, long-lived latently
Externí odkaz:
https://doaj.org/article/876ae1f41391450d9a63eaeb08d51d50
Autor:
Emily S Ryan, Luca Micci, Rémi Fromentin, Sara Paganini, Colleen S McGary, Kirk Easley, Nicolas Chomont, Mirko Paiardini
Publikováno v:
PLoS Pathogens, Vol 12, Iss 2, p e1005412 (2016)
In HIV/SIV-infected humans and rhesus macaques (RMs), a severe depletion of intestinal CD4(+) T-cells producing interleukin IL-17 and IL-22 associates with loss of mucosal integrity and chronic immune activation. However, little is known about the fu
Externí odkaz:
https://doaj.org/article/9de78cad5f60424ea14ccd5a4f346b88
Autor:
Luca Micci, Xavier Alvarez, Robin I Iriele, Alexandra M Ortiz, Emily S Ryan, Colleen S McGary, Claire Deleage, Brigitte B McAtee, Tianyu He, Cristian Apetrei, Kirk Easley, Savita Pahwa, Ronald G Collman, Cynthia A Derdeyn, Miles P Davenport, Jacob D Estes, Guido Silvestri, Andrew A Lackner, Mirko Paiardini
Publikováno v:
PLoS Pathogens, Vol 10, Iss 10, p e1004467 (2014)
In rhesus macaques (RMs), experimental depletion of CD4+ T-cells prior to SIV infection results in higher viremia and emergence of CD4-independent SIV-envelopes. In this study we used the rhesus recombinant anti-CD4 antibody CD4R1 to deplete RM CD4+
Externí odkaz:
https://doaj.org/article/43056c23f9dd49b0b7a34d7866d5af7c
Autor:
Gabriella d'Ettorre, Silvia Baroncelli, Luca Micci, Giancarlo Ceccarelli, Mauro Andreotti, Prachi Sharma, Gianfranco Fanello, Fausto Fiocca, Eugenio Nelson Cavallari, Noemi Giustini, Alessandra Mallano, Clementina M Galluzzo, Stefano Vella, Claudio M Mastroianni, Guido Silvestri, Mirko Paiardini, Vincenzo Vullo
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109791 (2014)
During HIV infection the severe depletion of intestinal CD4+ T-cells is associated with microbial translocation, systemic immune activation, and disease progression. This study examined intestinal and peripheral CD4+ T-cell subsets reconstitution und
Externí odkaz:
https://doaj.org/article/37a5706f263844a791cf278a5c5f7da9
Autor:
Suresh Pallikkuth, Luca Micci, Zachary S Ende, Robin I Iriele, Barbara Cervasi, Benton Lawson, Colleen S McGary, Kenneth A Rogers, James G Else, Guido Silvestri, Kirk Easley, Jacob D Estes, Francois Villinger, Savita Pahwa, Mirko Paiardini
Publikováno v:
PLoS Pathogens, Vol 9, Iss 7, p e1003471 (2013)
In pathogenic HIV and SIV infections of humans and rhesus macaques (RMs), preferential depletion of CD4⁺ Th17 cells correlates with mucosal immune dysfunction and disease progression. Interleukin (IL)-21 promotes differentiation of Th17 cells, long
Externí odkaz:
https://doaj.org/article/469083600eb542f78336284afc46cd6b